The impact of variations in membrane capacitance on the detected neural-electronic signal

Szlavik, Robert B.

doi:10.1109/iembs.2002.1053185

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…Recent efforts in neural-electronics, which specifically relates to the interaction of neurons with synthetic electronics, would benefit from an efficient and unified simulation and modeling tool. 13,18,19,20,21,22 The SPICE simulation platform provides an environment where complex systems involving synthetic electronic components, cells with Page 13.932.10…”

Section: Discussionmentioning

confidence: 99%

Nicotinic Acetylcholine Receptor Kinetics Of The Neuromuscular Junction Simulated Using Spice An Illustration Of Physiological Process Simulation With Conventional Circuit Simulation Software

Szlavik¹

2008 Annual Conference &Amp; Exposition Proceedings

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With the advent of modern day computational power, there is a great deal of interest in the simulation and modeling of complex biological systems. A significant effort is being made to develop generalized software packages for the simulation of cellular processes, metabolic pathways and complex biochemical reaction systems. The advantages to being able to implement and simulate complex biological systems in a virtual environment are several. Simulations of this type, if sufficiently detailed, provide experimental physiologists with the ability to visualize the dynamics of a given biological system of interest. The validity of hypotheses related to the system under study can be tested in a virtual environment prior to carrying out experimental studies. We discuss a systematic approach by which certain reaction balance equations can be transformed into equivalent circuit models that may then be implemented and simulated using SPICE (Simulation Program with Integrated Circuit Emphasis). To introduce the methodology, we develop a simulation for a single ligand-receptor interaction and then we utilize this framework to implement a simulation of nicotinic acetylcholine receptor kinetics at the postsynaptic membrane of the neuromuscular junction. Although the example studies that we present are specific to biochemical reaction systems associated with cellular processes, the procedure is equally applicable to any biochemical or chemical process for which analogous systems of mass balance equations exist that have an equivalent circuit analog. The overall approach described above is useful from the biomedical engineering educational perspective because SPICE simulators are readily accessible to students in freeware versions that they can use to simulate and visualize relatively complex physiological processes such as neurotransmitter/receptor dynamics.

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Section: Discussionmentioning

confidence: 99%

Nicotinic Acetylcholine Receptor Kinetics Of The Neuromuscular Junction Simulated Using Spice An Illustration Of Physiological Process Simulation With Conventional Circuit Simulation Software

Szlavik¹

2008 Annual Conference &Amp; Exposition Proceedings

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Neural-electronic inhibition simulated with a neuron model implemented in SPICE

Szlavik

Bhuiyan²,

Carver

et al. 2006

IEEE Trans. Neural Syst. Rehabil. Eng.

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Abstract-There have been numerous studies presented in the literature related to the simulation of the interaction between biological neurons and electronic devices. A complicating factor associated with these simulations is the algebraic complexity involved in implementation. This complication has impeded simulation of more involved neural-electronic circuitry and con sequently has limited potential advancements in the integration of biological neurons with synthetic electronics. In this paper, we describe a modification to a previously proposed SPICE based Hodgkin-Huxley neuron model that demonstrates more physio logically relevant electrical behavior. We utilize this SPICE based neuron model in conjunction with an external circuit that allows for artificial selective inhibition of neural spiking. The neural firing control scheme proposed herein would allow for action potential frequency modulation of neural activity that, if devel oped further, could potentially be applied to suppress undesirable neural activity that manifests symptomatically as the tremors or seizures associated with specific pathologies of the nervous system.

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The impact of variations in membrane capacitance on the detected neural-electronic signal

Cited by 2 publications

References 3 publications

Nicotinic Acetylcholine Receptor Kinetics Of The Neuromuscular Junction Simulated Using Spice An Illustration Of Physiological Process Simulation With Conventional Circuit Simulation Software

Nicotinic Acetylcholine Receptor Kinetics Of The Neuromuscular Junction Simulated Using Spice An Illustration Of Physiological Process Simulation With Conventional Circuit Simulation Software

Neural-electronic inhibition simulated with a neuron model implemented in SPICE

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