The impact of varicella vaccination on varicella-related hospitalization rates: global data review

Abstract

Objective:To describe the impact of varicella vaccination on varicella-related hospitalization rates in countries that implemented universal vaccination against the disease.Data source:We identified countries that implemented universal vaccination against varicella at the http://apps.who.int/immunization_monitoring/globalsummary/schedules site of the World Health Organization and selected articles in Pubmed describing the changes (pre/post-vaccination) in the varicella-related hospitalization rates in these countries, using the Keywords "varicella", "vaccination/vaccine" and "children" (or) "hospitalization". Publications in English published between January 1995 and May 2015 were included.Data synthesis:24 countries with universal vaccination against varicella and 28 articles describing the impact of the vaccine on varicella-associated hospitalizations rates in seven countries were identified. The US had 81.4%–99.2% reduction in hospitalization rates in children younger than four years, 6–14 years after the onset of universal vaccination (1995), with vaccination coverage of 90%; Uruguay: 94% decrease (children aged 1–4 years) in six years, vaccination coverage of 90%; Canada: 93% decrease (age 1–4 years) in 10 years, coverage of 93%; Germany: 62.4% decrease (age 1–4 years) in 8 years, coverage of 78.2%; Australia: 76.8% decrease (age 1–4 years) in 5 years, coverage of 90%; Spain: 83.5% decrease (age <5 years) in four years, coverage of 77.2% and Italy 69.7%–73.8% decrease (general population), coverage of 60%–95%.Conclusions:The publications showed variations in the percentage of decrease in varicella-related hospitalization rates after universal vaccination in the assessed countries; the results probably depend on the time since the implementation of universal vaccination, differences in the studied age group, hospital admission criteria, vaccination coverage and strategy, which does not allow direct comparison between data.

Eine für Alle – Alle für Eine(n)?

“…In einer von den Impfstoffherstellern finanzierten, regional begrenzten Untersuchung in Deutschland finden sich Hinweise auf das Auftreten eines Herdenschutzes, da eine Verminderung der Windpockeninzidenz auch in Altersgruppen nachweisbar war, die nicht Zielgruppe der Impfung waren [71]. Dies bestätigt sich auch in internationalen Studien [32]. Die für die Länder der EU errechneten Herdenimmunitätsschwellen zeigen eine auffallende Streuung zwischen 70 und 94% [16,40].…”

ВІТРЯНА ВІСПА У ДІТЕЙ (Огляд Літератури)

“…Профілактика вітряної віспи У 80 країнах світу використовується вакцинація живою вакциною проти ВВ [57][58][59]. На сьогодні в Украї-ні зареєстровано вакцини Окавакс (Okavax), Варилрікс (Varilrix).…”

Recomendación del CAVEI sobre la introducción de vacuna contra varicela al Programa Nacional de Inmunizaciones

“…En el caso de la vacunación universal, ésta reduce la frecuencia de enfermedades por VVZ, tanto en individuos vacunados como en aquellos no vacunados. Algunos sujetos vacunados podrían desarrollar la enfermedad, especialmente aquellos que recibieron sólo una dosis, pero, en estos casos, la manifestación del cuadro es leve o atenuada (menos de 50 lesiones y posiblemente afebril) 1,[3][4][5][6] . La Organización Mundial de la Salud (OMS) promueve la vacunación universal contra varicela cuando la infección por VVZ se considera un problema de salud pública o si se justifica por su impacto socioeconómico 1 .…”