2019
DOI: 10.2174/1570180815666180924110023
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The Impacts of Some Sedative Drugs on α -Glycosidase, Acetylcholinesterase and Butyrylcholinesterase Enzymes-potential Drugs for Some Metabolic Diseases

Abstract: Background: The present paper focuses on the in vitro inhibition of some sedative drugs such as Midazolam, Propofol, Hipnodex, Ketamine, and Pental sodium on acetylcholinesterase (AChE), Butyrylcholinesterase (BChE), and α-glycosidase (α-Gly) enzymes. Methods: These drugs were tested in diverse concentrations, which showed positive effects in vitro AChE, BChE, and α-Gly activities. Ki values were 20.14, 94.93, 636.78, 416.42, and 953.75 µM for AChE, 17.52, 32.03, 88.02, 93.48, and 91.84 µM for BChE, and 10.8… Show more

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Cited by 11 publications
(9 citation statements)
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“…Acetylcholinesterase (AChE), which is expressed in brain tissues and which operates to characterize ACh functioning in the central neural system alike in a balanced way, is a very efficient enzyme to hydrolyze ACh. [12][13][14][15][16] α-Glycosidase (α-GLY) as a glycoside hydrolase class, which hydrolyzes the α-glycosidic bonds in the carbohydrate molecules, [17] breaks the α-1,4-linked terminals of a sugar moiety. Also, it helps in the breakdown of carbohydrate molecules.…”
Section: Introductionmentioning
confidence: 99%
“…Acetylcholinesterase (AChE), which is expressed in brain tissues and which operates to characterize ACh functioning in the central neural system alike in a balanced way, is a very efficient enzyme to hydrolyze ACh. [12][13][14][15][16] α-Glycosidase (α-GLY) as a glycoside hydrolase class, which hydrolyzes the α-glycosidic bonds in the carbohydrate molecules, [17] breaks the α-1,4-linked terminals of a sugar moiety. Also, it helps in the breakdown of carbohydrate molecules.…”
Section: Introductionmentioning
confidence: 99%
“…The enzyme inhibitory effects of all the newly synthesized compounds 8a – m were evaluated against hCA I, hCA II (cytosolic), as well as AChE, BChE, and α‐glycosidase using the former assays. [ 44,45 ] The inhibitory activities were compared with AZA cytosolic hCA I and hCA II isoenzymes, tacrine for AChE and BChE, and acarbose for α‐glycosidase and α‐amylase enzymes (Table 1). The following structure–activity relationship and results were deduced as follows: …”
Section: Resultsmentioning
confidence: 99%
“…The compounds 8a – m have shown a significant inhibition at the nanomolar level against the cytosolic isoform hCA I, which exists in erythrocytes at the high level. [ 45 ] It is well known that lower K i values indicate a strong inhibitor affinity of inhibitors to enzymes. [ 46 ] All the target compounds exhibited inhibitory concentration of <1 µM except 8a and 8c .…”
Section: Resultsmentioning
confidence: 99%
“…In healthy persons, the pancreas enhances the secretion of insulin to regulate the postprandial blood glucose level. [8,9] In patients with type II diabetes, the cells fail to secrete enough insulin or are resistant to insulin, which leads to postprandial hyperglycemia. In this condition, after food intake, the production of insulin hormone is reduced, and low secretion of glucagon leads to the improper metabolism of glucose in liver and kidney.…”
Section: Introductionmentioning
confidence: 99%