The impacts of stress on sodium metabolism and copper accumulation in a freshwater fish

Harley, Rachel A.; Glover, Chris N.

doi:10.1016/j.aquatox.2013.12.004

Cited by 19 publications

(8 citation statements)

References 41 publications

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“…By virtue of a higher osmolality than their surroundings, fish in freshwater are faced with constant diffusive loss of ions to the water, and to achieve ion homeostasis they must take these ions up via the gill . Previous studies have shown that ion influx in inanga is highly sensitive to environmental stressors . However, similar to our observations for metabolic rate, there were no significant effects of diclofenac exposure on Na + and Ca 2+ influx in inanga.…”

Section: Discussionsupporting

confidence: 79%

“…They hatch on spring tides in estuarine nurseries and migrate out to the ocean as larvae, where they develop through the winter before migrating back to freshwater in the spring . The migration of juvenile inanga through estuaries is likely to expose them to high levels of environmental contaminants and, as adults, inanga inhabit near‐coastal streams that receive WWTP discharges.…”

Section: Introductionmentioning

confidence: 99%

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Acute exposure to an environmentally relevant concentration of diclofenac elicits oxidative stress in the culturally important galaxiid fish Galaxias maculatus

McRae

Glover

Burket

et al. 2017

Enviro Toxic and Chemistry

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Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) of growing concern in aquatic environments worldwide; nevertheless, knowledge of its effects on aquatic biota is restricted to a few model species with limited information regarding its mechanisms of impact. In the present study, diclofenac accumulation, its effects on metabolic rate, ionoregulation, and oxidative stress were examined at environmentally relevant (0.17 mg L À1 ) and elevated (763 mg L À1 ) concentrations in a culturally and economically important galaxiid fish, inanga (Galaxias maculatus), from the Southern Hemisphere. This species is among the most widespread freshwater fish in the world but its sensitivity to emerging contaminants is unknown. Following an acute 96-h exposure, bioconcentration of diclofenac was measured in the inanga whole-body, resulting in an estimated bioconcentration factor of 87 for the 0.17-mg L À1 exposure concentration, approaching values where transfer through the food chain should be considered. Lipid peroxidation in the liver was significantly elevated at both 0.17-and 763-mg L À1 exposure concentrations but lipid peroxidation in the kidney and gill decreased after diclofenac exposure. Catalase activity was also elevated in the liver of inanga but activity decreased in the gill. There were no effects of diclofenac on metabolic rate or ion (sodium and calcium) influx rates. These data indicate that toxicologically relevant adverse outcomes and bioconcentration of diclofenac at environmentally relevant levels warrant additional study in this important fish. Environ Toxicol Chem 2018;37:224-235. C 2017 SETAC

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Acute exposure to an environmentally relevant concentration of diclofenac elicits oxidative stress in the culturally important galaxiid fish Galaxias maculatus

McRae

Glover

Burket

et al. 2017

Enviro Toxic and Chemistry

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“…However, flow can also be modified by organismal activity. For example, stressed freshwater fish will increase their rate of gill ventilation, a phenomenon that contributes to increased accumulation of TE in the gill (Harley and Glover 2014). A similar pattern has been observed in bivalve molluscs (Tran et al 2002).…”

Section: Indirect Effects Of Geochemistry On Biological Factors That supporting

confidence: 56%

Geochemical and biological controls on the ecological relevance of total, dissolved, and colloidal forms of trace elements in large boreal rivers: review and case studies

et al. 2020

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The concentrations of trace elements (TEs) in large boreal rivers can fluctuate markedly due to changing water levels and flow rates associated with spring melt and variable contributions from tributaries and groundwaters, themselves having different compositions. These fluctuating and frequently high concentrations create regulatory challenges for protecting aquatic life. For example, water quality criteria do not account for changes in flow regimes that can result in TE levels that may exceed regulatory limits, and neither do they account for the markedly different lability and bioaccessibility of suspended solids. This review addresses the geochemical and biological processes that govern the lability and bioaccessibility of TEs in boreal rivers, with an emphasis on the challenges posed by the colloidal behaviour of many TEs, and their relationship to the dissolved fraction (i.e., <0.45 μm in size). After reviewing the processes and dynamics that give rise to the forms and behaviour of TEs in large boreal rivers, their relevance for aquatic organisms and the associated relationships between size and lability and bioaccessibility are discussed. The importance of biological variables and different forms of TEs for limiting lability and bioaccessibility are also addressed. Two case studies emphasize seasonal fluctuations and accompanying changes in the distribution of TE amongst different size fractions and associated colloidal species in large boreal rivers: the Northern Dvina and one of its tributaries, the Pinega River, both in Russia, and the Athabasca River in Alberta, Canada. Water quality in the Athabasca River is briefly discussed with respect to Canadian guidelines.

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“…The overlapping of stress- and salinity-related transcription factor interaction networks infers an intimate relationship between general emergency responses and osmoregulation (Figures 3 and 4 ). In fact, the effects of handling stress on the perturbation of hydromineral balance and osmoregulatory functions in fish were documented [ 43 , 51 ]. During an emergency, as induced by handling, fish inevitably increase their ventilation rate to obtain sufficient oxygen to meet the energy demand.…”

Section: Discussionmentioning

confidence: 99%

“…During an emergency, as induced by handling, fish inevitably increase their ventilation rate to obtain sufficient oxygen to meet the energy demand. However, the increase in ventilation also elevates ion and water fluxes, disrupting the equilibrium of ion absorption/excretion [ 51 ]. Activity or expression of Na-K-ATPase and Na-K-2Cl co-transporter changed in accordance to the changes of plasma osmolality induced by handling stress [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Discovery of osmotic sensitive transcription factors in fish intestine via a transcriptomic approach

et al. 2014

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BackgroundTeleost intestine is crucial for seawater acclimation by sensing osmolality of imbibed seawater and regulating drinking and water/ion absorption. Regulatory genes for transforming intestinal function have not been identified. A transcriptomic approach was used to search for such genes in the intestine of euryhaline medaka.ResultsQuantitative RNA-seq by Illumina Hi-Seq Sequencing method was performed to analyze intestinal gene expression 0 h, 1 h, 3 h, 1 d, and 7 d after seawater transfer. Gene ontology (GO) enrichment results showed that cell adhesion, signal transduction, and protein phosphorylation gene categories were augmented soon after transfer, indicating a rapid reorganization of cellular components and functions. Among >50 transiently up-regulated transcription factors selected via co-expression correlation and GO selection, five transcription factors, including CEBPB and CEBPD, were confirmed by quantitative PCR to be specific to hyperosmotic stress, while others were also up-regulated after freshwater control transfer, including some well-known osmotic-stress transcription factors such as SGK1 and TSC22D3/Ostf1. Protein interaction networks suggest a high degree of overlapping among the signaling of transcription factors that respond to osmotic and general stresses, which sheds light on the interpretation of their roles during hyperosmotic stress and emergency.ConclusionsSince cortisol is an important hormone for seawater acclimation as well as for general stress in teleosts, emergency and osmotic challenges could have been evolved in parallel and resulted in the overlapped signaling networks. Our results revealed important interactions among transcription factors and offer a multifactorial perspective of genes involved in seawater acclimation.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2164-15-1134) contains supplementary material, which is available to authorized users.

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The impacts of stress on sodium metabolism and copper accumulation in a freshwater fish

Cited by 19 publications

References 41 publications

Acute exposure to an environmentally relevant concentration of diclofenac elicits oxidative stress in the culturally important galaxiid fish Galaxias maculatus

Acute exposure to an environmentally relevant concentration of diclofenac elicits oxidative stress in the culturally important galaxiid fish Galaxias maculatus

Geochemical and biological controls on the ecological relevance of total, dissolved, and colloidal forms of trace elements in large boreal rivers: review and case studies

Discovery of osmotic sensitive transcription factors in fish intestine via a transcriptomic approach

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