The implications of inflammation in odontogenic keratocysts

Abstract

Rodu B, Tate AL, Martinez Jr MG. The implications of inflammation in odontogenic keratocysts. J Oral Pathol 1987: 16 518-521.The histologie features of 112 odontogenic keratoeysts (OKC's) were examined from both a clinical and histopathological perspective with emphasis on the microscopic presence of inflammation and its relationship to transformation of the classic epithelial cyst lining found in OKC's to a nonkeratinized lining characteristic of common inflammatory odontogenic cysts. Eighty-five (76%) of these cases exhibited inflammation. The sensitivity of inflammation as a predictor of this aforementioned transformation is 100%, and its positive predictive value is 88%. The specificity of the same parameters remains high at 73%. Using previous studies, the implications of these findings on the biologic behavior of OKC's is discussed with special reference to therapeutic considerations.

MIB-1 expression in odontogenic epithelial rests, epithelium of healthy oral mucosa and epithelium of selected odontogenic cysts

“…An increased proliferative marker expression was noted in the presence of heavy subepithelial inflammatory cell infiltration. It has been reported that chronic irritation such as that caused by chronic inflammation may stimulate proliferation of oral epithelial cells 13,19,24 . In this study, the MIB-1 expressions of oral mucosal epithelium and of the epithelial linings of cysts were similar.…”

Exploring the concept of inflammatory angiogenesis in keratocystic odontogenic tumor

“…KCOT has been reported to contain inflammation in its fibrous wall in 67.8% to 75% of cases (4,8) that can result from secondary infection from cortical bone perforations and periodontal ligament or other host-related causes apart from infectious agents (3). The effect of inflammation on the epithelial lining and connective tissue stroma of this tumor has been previously investigated and has shown changes in the morphology and proliferative activity of the epithelium and collagen structure of inflamed tumors and has even been proposed to complicate the diagnosis of this lesion (3,4,8-11). In addition numerous elements that can be secreted from inflammatory cells (e.g.…”

“…Our previous work suggested a possible role for angiogenesis in KCOT (1), which has also been corroborated by others (16,17). Considering the presence of inflammation in a considerable number of reported KCOTs (3,4,8,10,11), we intended to explore the concept of “inflammatory angiogenesis” in this odontogenic tumor. Therefore immuno-histochemistry was used to compare inflammation and angiogenesis between KCOT and radicular cyst (RC) which is a common inflammatory cyst.…”

Conservative approach to a large keratocystic odontogenic tumor of maxillary sinus

“…Bony cavity of the maxillary sinus. It is not known how the biologic behavior of the KCOT changes after marsupialization, but some believe it to be related to inflammation of the cyst lining [30]. Treatment of KCOT is controversial [27].…”