The Importance of Chlamydia Pneumoniae as a Pathogen

Tm, File; Jg, Bartlett; Gh, Cassell; Ca, Gaydos; Jt, Grayston; Mr, Hammerschlag; Rb, Jones; Jb, Kahn; Tj, Marrie; Ja, Ramírez Mayans; Saikku, Pekka; Schachter, Julius; Hr, Schumacher; We, Stamm; Cw, Stratton; Vl, Yu

doi:10.1097/00019048-199711002-00002

Cited by 10 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…49 -51 Such activation of plaque macrophages may reflect chronic infection of the arterial wall, 24,[52][53][54][55][56][57][58][59] or it may be the result of their interaction with oxidized or otherwise-modified lipoproteins. 60,61 To further explore markers of infection in atherosclerosis, we also measured the level of PCT, which was increased in patients with PAD.…”

Section: Erren Et Al Inflammation Cad and Pad 2359mentioning

confidence: 99%

Systemic Inflammatory Parameters in Patients With Atherosclerosis of the Coronary and Peripheral Arteries

Erren

Reinecke

Junker

et al. 1999

ATVB

276

149

View full text Add to dashboard Cite

show abstract

Section: Erren Et Al Inflammation Cad and Pad 2359mentioning

confidence: 99%

Systemic Inflammatory Parameters in Patients With Atherosclerosis of the Coronary and Peripheral Arteries

Erren

Reinecke

Junker

et al. 1999

ATVB

276

149

View full text Add to dashboard Cite

show abstract

Chlamydia pneumoniae: An Important Pathogen in Chronic Bronchitis

Lorenz¹

1999

Chlamydia Pneumoniae

View full text Add to dashboard Cite

Chlamydia pneumoniae Infections in Asthma

Gencay

Roth

2003

Am J Respir Med

View full text Add to dashboard Cite

Chlamydia pneumoniae is an intracellular pathogen that has been suggested to play a role in the pathology of asthma. However, so far none of the studies have provided clear evidence for a causative role of C. pneumoniae infections in asthma, although there is little doubt that chronic C. pneumoniae infection does aggravate asthma and should be treated. The diagnosis of C. pneumoniae infection is still a matter of concern for it is dependent on trained skilled personnel and can vary significantly between different diagnostic laboratories. This fact is also one of the major problems encountered when comparing epidemiological studies investigating the possible role of C. pneumoniae infections and their impact on the pathogenesis of other diseases. With regard to therapy, long-term treatment with macrolides is the best available method to eradicate C. pneumoniae. Successful therapy for C. pneumoniae, however, can also be complicated by the high possibility of de novo infection as epidemiological studies have shown that the prevalence of antibodies to C. pneumoniae increases with age in all populations studied. In the northern hemisphere the prevalence of C. pneumoniae is also affected by seasonal conditions. It is too early to draw any conclusions from the equatorial belt countries. The available data on C. pneumoniae in tropical countries indicate a much faster infection rate during early adulthood with 100% serological prevalence at an age greater than 25 years. This data, if confirmed, would argue against C. pneumoniae causing asthma since the asthma prevalence in those countries does not increase in a parallel pattern. An alternative interpretation of most studies could be that the increased rate of C. pneumoniae infections in patients with asthma results from a modified susceptibility towards the microorganism, due to yet unknown changes of the host cell's physiology. It should be kept in mind that increased prevalence of C. pneumoniae infection is not restricted to asthma. Further studies are needed to understand the role of C. pneumoniae, especially of chronic infection, in the pathogenesis of inflammatory diseases with a specific focus on the effect that the microorganism triggers in the infected host cell. Only when we understand what C. pneumoniae does to its host cell will we be able to judge its impact on the overall status of an affected patient, and this knowledge will help us to develop a successful therapy.

show abstract

The Importance of Chlamydia Pneumoniae as a Pathogen

Cited by 10 publications

References 0 publications

Systemic Inflammatory Parameters in Patients With Atherosclerosis of the Coronary and Peripheral Arteries

Systemic Inflammatory Parameters in Patients With Atherosclerosis of the Coronary and Peripheral Arteries

Chlamydia pneumoniae: An Important Pathogen in Chronic Bronchitis

Chlamydia pneumoniae Infections in Asthma

Contact Info

Product

Resources

About