The importance of complete blood count parameters in the screening of gastric cancer

Aksoy, Evrim Kahramanoğlu; Kantarcı, Selen; Torğutalp, Murat; Akpınar, Muhammet Yener; Sapmaz, Ferdane; Yalçın, Gülsüm Şeyma; Uzman, Metin; Şimşek, Gülçin Güler; Nazlıgül, Yaşar

doi:10.5114/pg.2019.88167

Cited by 13 publications

(20 citation statements)

References 25 publications

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“…LMR or AGR combined with CEA possessed a better AUC than LMR, AGR, or CEA used alone in discriminating colon cancer patients and benign colon diseases cases. Similar to this pilot study, a previous report displayed that LMR possessed a moderate ability (AUC = 0.71) and could contribute to distinguishing patients carrying gastric cancer from those with intestinal metaplasia [23]. In many malignancies, AGR exhibited good diagnostic e cacy (AUC = 0.81) in differentiating cancer patients from healthy controls [29].…”

Section: Discussionsupporting

confidence: 83%

“…In this retrospective analysis, we found that the colon cancer patients had a lower LMR level than the benign colon disease patients and healthy controls did, and this was consistent with previous ndings. For example, Evrim et al [23] observed that the level of monocyte-to-lymphocyte ratio (MLR) was higher in the gastric cancer group than it was in the intestinal metaplasia and healthy control groups. Luo et al [24] found that MLR was signi cantly elevated in patients carrying urothelial carcinoma of the bladder relative to healthy controls.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic value of the lymphocyte-to-monocyte and albumin-to-globulin ratios in patients with colon cancer

Huang¹,

Mo²,

Hu³

et al. 2020

Preprint

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Background: Ample evidence has revealed that the lymphocyte-to-monocyte ratio (LMR) and albumin-to-globulin ratio (AGR) are cancer-related inflammatory markers. The present study aimed to assess whether LMR and AGR, alone or in combination with carcinoembryonic antigen (CEA), was a useful diagnostic marker for colon cancer.Methods: This retrospective study enrolled 251 patients with colon cancer, 171 patients with benign colon diseases, and 187 healthy control subjects from January 2012 to September 2019. Mann-Whitney U test or Chi-square test were used to analyze differences between groups in laboratory parameters and clinicopathological features. The diagnostic value of LMR and AGR combined or not with CEA in colon cancer patients was determined via a receiver operating characteristic (ROC) curve.Results: The levels of LMR and AGR were decreased in the colon cancer group compared with the healthy control and benign colon disease groups. The LMR and AGR were correlated with lymph node metastasis, tumor size, and clinical stage. Moreover, AGR was associated with distant metastasis. Both the LMR (r = −0.137, p = 0.030) and AGR (r = −0.178, p = 0.005) were negatively correlated with the concentration of CEA. LMR or AGR combined with CEA could enhance sensitivity (75.30% for LMR + CEA, 58.57% for AGR + CEA) and generate larger area under curve (AUC; 0.75 for LMR + CEA, 0.74 for AGR + CEA) compared with the LMR (p < 0.001), AGR (p < 0.001), or CEA (p < 0.001) alone.Conclusion: The combination of LMR or AGR with CEA may enhance the sensitivity and diagnostic efficacy of detecting colon cancer from benign colon diseases.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Diagnostic value of the lymphocyte-to-monocyte and albumin-to-globulin ratios in patients with colon cancer

Huang¹,

Mo²,

Hu³

et al. 2020

Preprint

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“…[ 37 ] Contrariwise, lymphocyte proliferation is considered a protective factor against tumor growth. [ 36 ] It is important to note that in our research lymphocyte counts were significantly higher in patients with non- H pylori gastritis in comparison to healthy controls and H pylori gastritis. As it is well known that H pylori expresses a carcinogenic potential, [ 38 ] lack of relevant proliferation of lymphocytes in patients from group 1 might suggest a possible long-term malignant transformation.…”

Section: Discussionmentioning

confidence: 49%

“…Recent studies focused on assessing the usefulness of complete blood count parameters as a tool in gastric cancer screening. [ 36 ] Platelets appear to be involved in promoting carcinogenesis, by increasing the secretion of pro-inflammatory cytokines. [ 37 ] Contrariwise, lymphocyte proliferation is considered a protective factor against tumor growth.…”

Section: Discussionmentioning

confidence: 99%

Pediatric gastritis and its impact on hematologic parameters

Săsăran

Meliţ

Mocan³

et al. 2020

Medicine

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Non-invasive biomarkers, such as neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios, may predict inflammation in various disorders, including gastritis, according to recent data. Nevertheless, various studies reported an association between Helicobacter pylori ( H pylori ) and immune thrombocytopenia in both adults and pediatric patients. The objective of our study was to evaluate the impact of pediatric gastritis, caused or not by H pylori infection on erythrocytes, their parameters, thrombocytes, mean platelet volume, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). We performed a prospective, case–control study on 151 patients aged between 1 and 17 years who presented with chronic dyspeptic symptoms. An upper digestive endoscopy with gastric biopsies and a complete blood count was performed in each case. Control group consisted of 67 patients with normal histological findings, while the two study groups were divided into group 1— H pylori -induced gastritis (31 patients) and group 2—non- H pylori- induced gastritis (53 patients). Children from the rural area were more likely to develop both types of gastritis ( P < .01). No significant difference was found between either of the study groups and control group in terms of platelets, mean platelet volume, NLR and PLR ( P > .05). However, significantly higher values of lymphocytes were associated with non- H pylori -induced gastritis ( P < .01). Comparison of the two study groups did not reflect any significant differences in terms of hematological parameters. When assessing these constants in relation to gastritis severity, severe gastritis led to a compelling decrease in hemoglobin (Hb) and hematocrit (Htc) levels. The comparison of parameters between severe, moderate, and mild gastritis did not reveal any significant results. Childhood and adolescent gastritis does not produce a significant effect upon platelet counts, their mean volume, PLR or NLR, according to our study. An important increase in lymphocyte count might predict non- H pylori pediatric gastritis. Moreover, severe gastritis might result in an important decrease in Hb and Htc levels.

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“…Neutrophils may promote tumor initiation, progression, and metastasis through the release of several cytokines. IL-17a (a member of the IL-17 family), in particular, is significant in autoimmune diseases and inflammatory processes [91,92]. What makes it particularly interesting is that after binding with its IL-17Ra receptor, IL-17a acts through a novel ACT1-dependent pathway, as opposed to the JAK2-STAT3 pathway triggered by Th1 and Th2 cell families [93][94][95].…”

Section: Il-17amentioning

confidence: 99%

Immunological Aspects of the Tumor Microenvironment and Epithelial-Mesenchymal Transition in Gastric Carcinogenesis

Baj

Brzozowska

Forma

et al. 2020

IJMS

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Infection with Helicobacter pylori, a Gram-negative, microaerophilic pathogen often results in gastric cancer in a subset of affected individuals. This explains why H. pylori is the only bacterium classified as a class I carcinogen by the World Health Organization. Several studies have pinpointed mechanisms by which H. pylori alters signaling pathways in the host cell to cause diseases. In this article, the authors have reviewed 234 studies conducted over a span of 18 years (2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018)(2019)(2020). The studies investigated the various mechanisms associated with gastric cancer induction. For the past 1.5 years, researchers have discovered new mechanisms contributing to gastric cancer linked to H. pylori etiology. Alongside alteration of the host signaling pathways using oncogenic CagA pathways, H. pylori induce DNA damage in the host and alter the methylation of DNA as a means of perturbing downstream signaling. Also, with H. pylori, several pathways in the host cell are activated, resulting in epithelial-to-mesenchymal transition (EMT), together with the induction of cell proliferation and survival. Studies have shown that H. pylori enhances gastric carcinogenesis via a multifactorial approach. What is intriguing is that most of the targeted mechanisms and pathways appear common with various forms of cancer.EMT refers to the process by which the mesenchymal phenotype is acquired by epithelial cells (ECs) mainly via the reduction of their intracellular adhesions and proliferative capacity (Figure 1.) [47].

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The importance of complete blood count parameters in the screening of gastric cancer

Cited by 13 publications

References 25 publications

Diagnostic value of the lymphocyte-to-monocyte and albumin-to-globulin ratios in patients with colon cancer

Diagnostic value of the lymphocyte-to-monocyte and albumin-to-globulin ratios in patients with colon cancer

Pediatric gastritis and its impact on hematologic parameters

Immunological Aspects of the Tumor Microenvironment and Epithelial-Mesenchymal Transition in Gastric Carcinogenesis

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