The importance of consumption of the epidermis in malignant melanoma and correlation with clinicopathological prognostic parameters

Seçkin, Selda; Ozgun, Elmas

doi:10.5146/tjpath.2011.01047

Cited by 1 publication

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“…Consumption was not identified, however, in any of their 146 low‐grade Clark/dysplastic, congenital or conventional nevi when using a definition that required loss of the rete ridge pattern. Additional studies have confirmed the utility of consumption in diagnosing melanoma and suggest that it may occur more commonly in certain genetic subtypes of melanoma (such as those with gains in MYC at 8q24) . Many of these studies also confirmed the association of consumption with increasing Breslow thickness and ulceration …”

Section: Discussionmentioning

confidence: 82%

Epidermal consumption in benign and malignant melanocytic neoplasms

et al. 2015

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Consumption of the epidermis associated with effacement of the rete ridge pattern has been cited as a useful criterion in the diagnosis of melanoma, but the significance of consumption in the absence of rete ridge effacement is unknown. We evaluated 701 melanocytic neoplasms for presence and 'grade' of consumption by melanocytic nests relative to diagnosis, body location, gender and age. We defined 1+ consumption as collections of melanocytes occupying greater than two thirds of the viable epidermis, with or without loss of the rete ridge pattern. Nests extending to the bottom of, within, and through the granular layer were graded 2+, 3+ and 4+, respectively. Consumption was more frequent and higher grades were found in melanomas followed by Spitz nevi compared with conventional melanocytic nevi (p < 0.001). Melanomas with higher Breslow thickness showed higher grades (p < 0.05). In conventional nevi, consumption occurred most frequently in back (13.7%), acral (11.9%) and scalp (9.8%) locations. Consumption without the requirement for rete ridge effacement occurs more frequently and at higher grades in melanoma. Higher grades correlate with higher Breslow thickness. Consumption is also common in Spitz nevi and occurs at lower grades in conventional (non-Spitz) nevi, especially on the back, the scalp and at acral sites.

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Section: Discussionmentioning

confidence: 82%