2021
DOI: 10.1097/bs9.0000000000000075
|View full text |Cite
|
Sign up to set email alerts
|

The importance of genomic predictors for clinical outcome of hematological malignancies

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
8
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
6

Relationship

5
1

Authors

Journals

citations
Cited by 6 publications
(8 citation statements)
references
References 20 publications
0
8
0
Order By: Relevance
“…Differential VJ rearrangements were identified using the “limma” package ( 54 ). Kaplan-Meier curves of DFS and OS were compared by the log-rank test ( 55 ). Comparison of the 2 groups of quantitative variables was conducted by the Mann-Whitney-Wilcoxon test.…”
Section: Methodsmentioning
confidence: 99%
“…Differential VJ rearrangements were identified using the “limma” package ( 54 ). Kaplan-Meier curves of DFS and OS were compared by the log-rank test ( 55 ). Comparison of the 2 groups of quantitative variables was conducted by the Mann-Whitney-Wilcoxon test.…”
Section: Methodsmentioning
confidence: 99%
“…The immune escape of tumor cells is a crucial cause of relapse and refractory AML (3). It has been shown that in the tumor microenvironment, tumor cells induce the expression of immune checkpoint (IC) genes, such as programmed cell death protein 1 (PD-1), cytotoxic T lymphocyte-associated molecule-4 (CTLA-4), and lymphocyte-activation gene 3 (LAG-3), leading to T cell exhaustion and immune escape (4)(5)(6)(7)(8)(9). Clinical trials of targeted inhibitory antibodies, such as anti-PD-1 and anti-CTLA-4, in solid tumors have demonstrated their significant effects (10).…”
Section: Introductionmentioning
confidence: 99%
“…It is common practice to detect cytogenetic changes in patients during the diagnosis of hematological malignancies to stratify risk and predict clinical outcomes, but due to the heterogeneity and complexity of the diseases, individuals differ in responses to chemotherapy, duration of remission, and recurrence although they have the same cytogenetic changes [ 52 ]. In recent years, genetic aberrations have significant practical value, and some have been used in National Comprehensive Cancer Network (NCCN) guidelines [ 53 , 54 ].…”
Section: Discussionmentioning
confidence: 99%