The Importance of Long-Term Monitoring to Evaluate the Microvascular Response to Light-Based Therapies

Choi, Bernard; Jia, Wangcun; Channual, Jennifer; Kelly, Kristen M.; Lotfi, Justin

doi:10.1038/sj.jid.5700991

Cited by 46 publications

(66 citation statements)

References 18 publications

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“…The relative blood flow is equivalent to the inverse of the correlation time (1/s c ) and, thus, a speckle flow index (SFI) map is computed. For this study, we set the value of T to 10 milliseconds which was selected based on flow phantom experiments performed previously [7].…”

Section: Speckle Image Processingmentioning

confidence: 99%

“…Laser Doppler flowmetry and laser Doppler imaging, both established methods in studies of microvascular skin characterization, are limited by the need for mechanical scanning of the probe laser beam, resulting in long (on the order of minute) image collection times. We instead propose use of laser speckle imaging (LSI) [6][7][8][9] to provide real-time, quantitative feedback during laser surgery. LSI relies on acquisition and analysis of a single image captured at an exposure time that is considerably longer than a characteristic correlation time associated with the fluctuation frequency.…”

Section: Introductionmentioning

confidence: 99%

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Noninvasive blood flow imaging for real‐time feedback during laser therapy of port wine stain birthmarks

et al. 2008

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Background and Objectives-During laser therapy of port wine stain (PWS) birthmarks, regions of persistent perfusion may exist. Immediate retreatment of such regions may improve PWS laser therapeutic outcome. To address this need, we propose use of laser speckle imaging (LSI) to provide real-time, quantitative feedback during laser surgery. Herein, we present in vitro and in vivo data collected with a clinic-based LSI instrument.

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Section: Speckle Image Processingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Noninvasive blood flow imaging for real‐time feedback during laser therapy of port wine stain birthmarks

et al. 2008

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“…A queue buffer allows the transfer of data between different parts of a block diagram-in this case, the two while loops. As soon as an image 5 LabVIEW pseudocode used to acquire and process data from the camera. Two for loops are employed such that images can be processed while newer images are acquired.…”

Section: Real-time Labview Lsi Visualization With Gpu Integrationmentioning

confidence: 99%

“…Recently, LSI has found uses in monitoring blood flow in the brain, 2 retina, 3 and skin. 4,5 Conversion of raw laser speckle images to speckle contrast (SC) and speckle flow index (SFI) images is computationally intensive and CPU-based algorithms are not well suited for realtime processing of high-resolution images, let alone real-time visualization of the postprocessed images. One of the reasons for the slow processing times is that the architecture of modern CPUs is optimized for execution of sequential code, with only a fraction of CPU transistors dedicated to arithmetic operations.…”

Section: Introductionmentioning

confidence: 99%

Real-time blood flow visualization using the graphics processing unit

2011

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Abstract. Laser speckle imaging (LSI) is a technique in which coherent light incident on a surface produces a reflected speckle pattern that is related to the underlying movement of optical scatterers, such as red blood cells, indicating blood flow. Image-processing algorithms can be applied to produce speckle flow index (SFI) maps of relative blood flow. We present a novel algorithm that employs the NVIDIA Compute Unified Device Architecture (CUDA) platform to perform laser speckle image processing on the graphics processing unit. Software written in C was integrated with CUDA and integrated into a LabVIEW Virtual Instrument (VI) that is interfaced with a monochrome CCD camera able to acquire high-resolution raw speckle images at nearly 10 fps. With the CUDA code integrated into the LabVIEW VI, the processing and display of SFI images were performed also at ∼10 fps. We present three video examples depicting real-time flow imaging during a reactive hyperemia maneuver, with fluid flow through an in vitro phantom, and a demonstration of real-time LSI during laser surgery of a port wine stain birthmark. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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“…The relative blood flow is equivalent to the inverse of the correlation time (1/τ c ) and, thus, a speckle flow index (SFI) map is computed. For this study, we set the value of T to 10 milliseconds which was selected based on flow phantom experiments performed previously [7].…”

Section: Speckle Image Processingmentioning

confidence: 99%

Noninvasive Blood Flow Imaging for Real-Time Feedback During Laser Therapy of Port Wine Stain Birthmarks

Huang

Tran

Nelson

et al. 2008

ASME 2008 3rd Frontiers in Biomedical Devices Conference

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The Importance of Long-Term Monitoring to Evaluate the Microvascular Response to Light-Based Therapies

Cited by 46 publications

References 18 publications

Noninvasive blood flow imaging for real‐time feedback during laser therapy of port wine stain birthmarks

Noninvasive blood flow imaging for real‐time feedback during laser therapy of port wine stain birthmarks

Real-time blood flow visualization using the graphics processing unit

Noninvasive Blood Flow Imaging for Real-Time Feedback During Laser Therapy of Port Wine Stain Birthmarks

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