The importance of minor salivary gland biopsy in sjÃ¶gren syndrome diagnosis and the clinicopathological correlation

Serın, Gürdenız; Karabulut, Gonca; Kabasakal, Yasemin; Kandıloğlu, Gülşen

doi:10.5146/tjpath.2015.01346

Cited by 6 publications

(4 citation statements)

References 13 publications

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“…Moreover, inter-and intra-rater agreements may be low for pathologists, which is due to the use of different criteria for diagnosis and variable interpretations of scoring of foci. Thus, biopsy of the minor salivary glands of the lips can only serve as a gold standard of diagnosis for experienced and calibrated pathologists, who use the criteria with utmost precision [14,[29][30][31][32]. However, review of diagnostic criteria is among the most important challenges for pathologists.…”

Section: Discussionmentioning

confidence: 99%

“…In this process, the results of laboratory tests matching the reduction in salivary flow rate can indicate Sjogren's syndrome even without histopathological confirmation of focal lymphocytic infiltration of salivary glands. It should be noted that antibody titers of patients with Sjogren's syndrome are correlated with the degree of lymphocytic infiltration [28,[31][32][33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

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Salivary Calcium Level in Patients with Sjogren's Syndrome

Rabiei

Davalloo

Masooleh

et al. 2022

J Res Dent Maxillofac Sci

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Background and Aim: This study assessed the salivary calcium level, salivary flow rate, and dental problems of patients with Sjogren's syndrome. Materials and Methods: This case-control study was conducted on 30 patients with Sjogren's syndrome and 30 healthy controls. The salivary flow rate, salivary calcium level, and the decayed, missing, and filled surfaces (DMFS) index were recorded. The total salivary concentration of calcium was assessed by atomic absorption spectrometry using Arsenazo III calcium-sensitive dye. The Kolmogorov-Smirnov test, the parametric independent t-test, and the Mann Whitney U test were used to compare the variables between the two groups. The Pearson's and the Spearman's correlation coefficients were used to analyze the relationship between quantitative variables. Results: The salivary calcium level was insignificantly higher in the case group (4.44±0.78 mg/dL versus 4.22±0.51 mg/dL, P=0.189, independent t-test). The salivary flow rate in patients with Sjogren's syndrome was significantly lower than that in controls (0.12±0.07 mL/minute versus 0.4±0.14 mL/minute, P<0.0001, Mann Whitney U test). The cut-off point for discrimination of patients with Sjogren's syndrome was 0.165 mL/minute with 96% sensitivity and 90% specificity. The DMFS score was higher in the case group (78.08 versus 38.35, P<0.0001 based on independent t-test). The salivary flow rate was responsible for 34% of the changes in DMFS score while the calcium level was responsible for 0.2% of the changes. Conclusion:The salivary calcium level cannot serve as an indicator for the Sjogren's syndrome while 0.165 mL/min salivary flow rate is the cutoff point for accurate case detection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Salivary Calcium Level in Patients with Sjogren's Syndrome

Rabiei

Davalloo

Masooleh

et al. 2022

J Res Dent Maxillofac Sci

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“…Histological salivary tissues were scored as follows: Grade 0, tissues without mononuclear infiltration; Grade 1, tissues with dispersed lymphocytic infiltration; Grade 2, with moderate infiltration; Grade 3 with one or more focus groups of 50 or more lymphocytes [ 26 ].…”

Section: Methodsmentioning

confidence: 99%

Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model

Ross

Fabersani

Russo

et al. 2017

BioMed Research International

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Iodine is an important micronutrient required for nutrition. Excess iodine has adverse effects on thyroid, but there is not enough information regarding its effect on salivary glands. In addition to food and iodized salt, skin disinfectants and maternal nutritional supplements contain iodide, so its intake could be excessive during pregnancy, lactation, and infancy. The aim of this work was to evaluate the effect of excess iodide ingestion on salivary glands during mating, gestation, lactation, and postweaning period in mouse. During assay, mice were allocated into groups: control and treatment groups (received distilled water with NaI 1 mg/mL). Water intake, glandular weight, and histology were analyzed. Treatment groups showed an increase in glandular weight and a significantly (p < 0.05) higher water intake than control groups. Lymphocyte infiltration was observed in animals of treatment groups, while there was no infiltration in glandular sections of control groups. Results demonstrated that a negative relationship could exist between iodide excess and salivary glands. This work is novel evidence that high levels of iodide intake could induce mononuclear infiltration in salivary glands. These results should be considered, especially in pregnant/lactating women, to whom a higher iodine intake is usually recommended.

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“…Two years later, during a regular visit, and according to the ACR criteria and the presence of an RA diagnosis, she was diagnosed with secondary Sjögren's syndrome [9,10] . Oral (saliva substitutes) and ocular (serum tear drops, topical corticosteroids) therapies were initiated, with persistence of 200 mg/day of hydroxychloroquine, and 10 mg/week of Methotrexate [11] , 100 mg/day L-thyroxin, and oral and ocular topical treatment.…”

Section: Her Past Medical Historymentioning

confidence: 99%

Coexistence of Hashimoto’s thyroiditis, rheumatoid arthritis, Sjogren’s syndrome, and ulcerative colitis

Kudsi,

Khalayli,

Haj Ali

et al. 2024

International Journal of Surgery: Global Health

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Introduction and importance: The coexistence of Hashimoto’s thyroiditis and ulcerative colitis has been previously mentioned, as these diseases are autoimmune diseases. Limited data about the coexistence of rheumatoid arthritis in patients with Hashimoto’s thyroiditis have been published till now. Meanwhile, the coexistence of Sjogren’s syndrome during the course of rheumatoid arthritis is well known. The coexistence of Hashimoto’s thyroiditis, Sjogren’s syndrome, and ulcerative colitis has also been reported in rare cases. Case presentation: A 32-year-old female, with a 10-year history of Hashimoto’s thyroiditis, 4 years of rheumatoid arthritis, and 2 years of secondary Sjogren’s syndrome, presented to our Rheumatology Department, complaining of fatigue, weight loss, intermittent abdominal pain, and bloody diarrhea for the last 6 weeks. Her colonoscopy findings were compatible with a diagnosis of ulcerative colitis. Clinical discussion: Multiple autoimmune syndromes are defined as the presence of three or more autoimmune diseases in the same patient. They have an increased frequency in patients with a previous history of another autoimmune disease, and a higher correlation with females. The prevalence is rare and was documented only by two systematic reviews, with the rest being separate case reports. Autoimmune thyroid disease and Sjögren’s syndrome were the most frequent diseases encountered, followed by rheumatoid arthritis, and systemic lupus erythematosus. The presence of these autoimmune diseases together suggests that they share a common pathological and physiological genesis. Conclusion: This is the first case report, to our knowledge, that describes the coexistence of Hashimoto’s thyroiditis, rheumatoid arthritis, Sjogren’s syndrome, and ulcerative colitis within 10 years, without a positive family history or psychological stress. Therefore, further studies and long-term surveys are needed to identify other factors that can contribute to the coexistence of these rare diseases.

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The importance of minor salivary gland biopsy in sjÃ¶gren syndrome diagnosis and the clinicopathological correlation

Cited by 6 publications

References 13 publications

Salivary Calcium Level in Patients with Sjogren's Syndrome

Salivary Calcium Level in Patients with Sjogren's Syndrome

Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model

Coexistence of Hashimoto’s thyroiditis, rheumatoid arthritis, Sjogren’s syndrome, and ulcerative colitis

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