The importance of MRI review following the diagnosis of atypical cartilaginous tumour using image-guided needle biopsy

Saifuddin, Asif; Oliveira, Inês; Singla, Nehal; Chavda, Anesh; Khoo, Michael; O’Donnell, Paul

doi:10.1007/s00256-020-03578-7

Cited by 7 publications

(8 citation statements)

References 29 publications

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“…Compared with other types of bone tumors, high rates of discrepancies between biopsy findings and final diagnoses were reported in cartilaginous tumors [ 3 , 5 , 7 , 24 ]. In previous studies, 14–57% of patients with cartilaginous tumors had discrepancies in the histological grade between biopsy results and final diagnosis [ 5 , 7 , 25 , 26 ]. Especially, histological distinction of ACT/grade I chondrosarcoma from enchondroma is difficult in many cases for pathologists because of their similar cytology, cellularity, and cartilaginous matrix [ 9 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

A Radiological Scoring System for Differentiation between Enchondroma and Chondrosarcoma

Miwa

Yamamoto

Hayashi

et al. 2021

Cancers

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Background: It is challenging to differentiate between enchondromas and atypical cartilaginous tumors (ACTs)/chondrosarcomas. In this study, correlations between radiological findings and final diagnosis were investigated in patients with central cartilaginous tumors. Methods: To evaluate the diagnostic usefulness of radiological findings, correlations between various radiological findings and final diagnoses were investigated in a cohort of 81 patients. Furthermore, a new radiological scoring system was developed by combining radiological findings. Results: Periosteal reaction on X-ray (p = 0.025), endosteal scalloping (p = 0.010) and cortical defect (p = 0.002) on CT, extraskeletal mass (p < 0.001), multilobular lesion (p < 0.001), abnormal signal in adjacent tissue (p = 0.004) on MRI, and increased uptake in bone scan (p = 0.002) and thallium scan (p = 0.027) was significantly correlated with final diagnoses. Based on the correlations between each radiological finding and postoperative histological diagnosis, a radiological scoring system combining these findings was developed. In another cohort of 17 patients, the sensitivity, specificity, and accuracy of the radiological score rates for differentiation between enchondromas and ACTs/chondrosarcomas were 88%, 89%, and 88%, respectively (p = 0.003). Conclusion: Radiological assessment with combined radiological findings is recommended to differentiate between enchondromas and ACT/chondrosarcomas.

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Section: Discussionmentioning

confidence: 99%

A Radiological Scoring System for Differentiation between Enchondroma and Chondrosarcoma

Miwa

Yamamoto

Hayashi

et al. 2021

Cancers

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“…Moreover, the total sample size was 568 patients with a range of 9 to 179 sample sizes. Among these studies, five studies were conducted in the United Kingdom [ 28 - 32 ], two in the United States [ 33 , 34 ], two in Germany [ 35 , 36 ], two in Italy [ 37 , 38 ], two in China [ 39 , 40 ], one in Korea [ 41 ], one in Japan [ 42 ], and one in Switzerland [ 43 ]. The baseline and summary of the included studies are presented in Table 1 .…”

Section: Reviewmentioning

confidence: 99%

“…The overall quality of the included study varied hugely. According to the risk-assessment results, we found that seven studies [ 30 - 32 , 34 , 39 - 41 ] had a low risk of bias while only two were classified as high-risk studies [ 29 , 36 ]. In terms of confounding bias, only two studies [ 34 , 42 ] had a moderate risk of bias while none of the studies had a high risk.…”

Section: Reviewmentioning

confidence: 99%

“…Among all the included studies, only seven studies [ 29 , 30 , 32 , 33 , 35 , 36 , 42 ] reported the efficacy and overall accuracy in the diagnosis and differentiation of CS. Saifuddin et al reported an overall accuracy of 92% in a pre-biopsy-two-reader approach with a sensitivity of 91% [ 32 ]. Meanwhile, Yoshimura et al reported high sensitivity rates in terms of entrapped fat, ring and arc enhancement, and soft-tissue mass formation characteristics [ 42 ].…”

Section: Reviewmentioning

confidence: 99%

Section: Accuracy Of Mris In Diagnosis and Detecting Characteristicsmentioning

confidence: 99%

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Magnetic Resonance Imaging Role in the Differentiation Between Atypical Cartilaginous Tumors and High-Grade Chondrosarcoma: An Updated Systematic Review

Alhumaid

Alharbi

Aljubair

2020

Cureus

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Chondrosarcoma (CS) is a malignant tumor affecting the bones while atypical cartilaginous tumors (ACTs) are chondral tumors with moderate cellularity, mild atypia, and with myxoid changes and mild metastatic ability. Both can have one of the worst prognoses if not identified early enough. Magnetic resonance imaging (MRI) has been one of the modalities to detect such tumors and we aim to determine the common characteristic and features to be seen while screening for CS or ACTs. We conducted a systematic review of the previously published reports that investigated the diagnostic ability of MRI and the reported characteristics that can differentiate between ACTs and high-grade chondrosarcomas (HGCS). A comprehensive relevant database search was performed to include all the relevant studies. Among these studies, seven studies investigated the overall accuracy in the classification of the different chondroma types. Additionally, many studies reported the characteristic findings of each tumor according to the MRI results. These characteristics mainly included trapped fat, bone marrow edema, cortical damage, and soft-tissue expansion. Therefore, further attention should be given to these criteria for better assessment, differentiation, and favorable outcomes. MRI can efficiently identify some of the characteristics of both ACTs and HGCS. However, combining it with other radiological modalities may lead to a better differentiation. The detection of ACTs and HGCS lesions with MRI solely has been doubted before in the literature.

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Chondrosarcoma of the Appendicular Skeleton

Geiger

Bernthal

2021

Chondrosarcoma

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The importance of MRI review following the diagnosis of atypical cartilaginous tumour using image-guided needle biopsy

Cited by 7 publications

References 29 publications

A Radiological Scoring System for Differentiation between Enchondroma and Chondrosarcoma

A Radiological Scoring System for Differentiation between Enchondroma and Chondrosarcoma

Magnetic Resonance Imaging Role in the Differentiation Between Atypical Cartilaginous Tumors and High-Grade Chondrosarcoma: An Updated Systematic Review

Chondrosarcoma of the Appendicular Skeleton

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