2016
DOI: 10.1007/s10529-016-2163-7
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The importance of stem cell engineering in head and neck oncology

Abstract: Head and neck squamous cell carcinoma is the sixth leading cause of cancer worldwide. The most common risk factors are carcinogens (tobacco, alcohol), and infection of the human papilloma virus. Surgery is still considered as the treatment of choice in case of head and neck cancer, followed by a reconstructive surgery to enhance the quality of life in the patients. However, the widespread use of artificial implants does not provide appropriate physiological activities and often cannot act as a long-term soluti… Show more

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Cited by 14 publications
(9 citation statements)
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“…1,2 Primary laryngeal reconstruction could range from a single cartilage, such as the thyroid cartilage, to the entire larynx; thus knowledge about each laryngeal cartilaginous component is required to enable the development of suitable scaffolding materials to engineer these cartilages. There have been some initial attempts to tissue engineer the hemilarynx, using either decellularized matrix 3 or synthetic materials 1,2,[4][5][6][7][8] but there have been issues with incomplete cellularization and inadequate mechanical properties. Because of the roles of these cartilages in keeping the airway patent, it is critical that the cartilaginous structures, especially the cricoid and thyroid cartilages, are functional immediately upon placement into the patient.…”
Section: Introductionmentioning
confidence: 99%
“…1,2 Primary laryngeal reconstruction could range from a single cartilage, such as the thyroid cartilage, to the entire larynx; thus knowledge about each laryngeal cartilaginous component is required to enable the development of suitable scaffolding materials to engineer these cartilages. There have been some initial attempts to tissue engineer the hemilarynx, using either decellularized matrix 3 or synthetic materials 1,2,[4][5][6][7][8] but there have been issues with incomplete cellularization and inadequate mechanical properties. Because of the roles of these cartilages in keeping the airway patent, it is critical that the cartilaginous structures, especially the cricoid and thyroid cartilages, are functional immediately upon placement into the patient.…”
Section: Introductionmentioning
confidence: 99%
“…To obtain an ESC, researchers either implant the nucleus of a somatic cell into a nuclear-free oocyte, or use a defined chemical method to transform an oocyte without fertilization. 105 ESCs differentiate into functional chondrocytes. However, their clinical application is restricted due to ethical issues and potential tumor-inducing risks.…”
Section: Recellularization Of Dtsmentioning
confidence: 99%
“…Telomere length was assessed using two pairs of primers, one telomere-specific (Telo) and one a single copy gene-specific albumin ALB (Table 2), as previously described [13,14]. Briefly, specific primers with an efficiency close to 100% (98 ± 2%) were used in a SYBR Green based assay with FastStart Essential SYBR Green I Master (Roche Applied Science, Penzberg, Germany).…”
Section: Assessment Of Relative Telomere Lengthmentioning
confidence: 99%