2008
DOI: 10.1099/mic.0.2007/012534-0
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The importance of the Rcs phosphorelay in the survival and pathogenesis of the enteropathogenic yersiniae

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Cited by 34 publications
(35 citation statements)
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“…Genome expression studies, in fact, show that most of the genes of the Rcs regulon encode proteins related to envelope homeostasis (20,23,30,31,46,55). Here, we also studied the role of IgaA as an attenuator of the RcsCDB system with a strategy based on genome expression profiling.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Genome expression studies, in fact, show that most of the genes of the Rcs regulon encode proteins related to envelope homeostasis (20,23,30,31,46,55). Here, we also studied the role of IgaA as an attenuator of the RcsCDB system with a strategy based on genome expression profiling.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, 46 genes with altered expression were identified when rcsB ϩ and ⌬rcsB strains were compared (46); 32 genes were identified when rcsC ϩ and ⌬rcsC strains grown at low temperatures, in glucose, and with high zinc concentrations were compared (30); and 149 genes were identified when profiles of rcsC ϩ and ⌬rcsC bacteria overexpressing DjlA were compared (23). The Rcs regulon of Yersinia pseudotuberculosis has been estimated to be formed by at least 136 genes, with 60% of the genes encoding functions related to envelope homeostasis (31). In serovar Typhimurium, 26 RcsB-dependent but RcsA-independent genes were reported upon exposure of bacteria to sublethal concentrations of antimicrobial peptides (20).…”
mentioning
confidence: 99%
“…The Rcs phosphorelay has been implicated in the synthesis of virulence factors in Pcc and other plant-pathogenic bacteria and also in human pathogens (Hinchliffe et al, 2008;Mouslim et al, 2004;Wang et al, 2009Wang et al, , 2007. RcsB activates the biosynthesis of capsular exopolysaccharides, transcription of the cell division gene, ftsZ, transcription of a cell envelope protein, osmC, and transcription of RprA RNA to increase expression of the stationary-phase sigma factor, RpoS, in E. coli (Carballes et al, 1999;Davalos-Garcia et al, 2001;Gervais et al, 1992;Gottesman et al, 1985;Majdalani et al, 2002).…”
Section: Introductionmentioning
confidence: 99%
“…Tamayo et al (2010) found that pathogenic Vibrio cholera in both dispersed and intact biofilms vastly out-competed planktonic populations. Huang et al (2008) found that that Streptococcus mutans utilizes the general secretory pathway to secrete virulence factor proteins and the level of SecA, the key factor in the general secretory pathway, was influenced significantly by biofilm formation. PrfA is the critical virulence transcription factor that regulates the switch from extracellular, flagellum-propelled bacterium to intracellular pathogen in L. monocytogenes.…”
Section: Biofilm and Virulencementioning
confidence: 99%
“…The humanenteropathogenic species Yersinia enterocolitica and Y. pseudotuberculosis and the highly virulent plague bacillus Y. pestis, represent ideal species to study how bacteria adapt from different environments and evolve to be highly virulent. The work of Hinchliffe et al (2008) found that several alleged virulence determinants of the Yersinia species, regulated by a phosphorelay, also regulated proteins involved in biofilm formation, motility, mammalian cell adhesion and stress survival. Escherichia coli are one of the first colonizers of the gastrointestinal tract of newborns and a normal component of the gastrointestinal flora of almost every human being.…”
Section: Biofilm and Virulencementioning
confidence: 99%