The importance of vessel factors for stent deployment in diseased arteries

Schiavone, Alessandro; Zhao, Liguo

doi:10.15761/jic.1000130

Cited by 5 publications

(1 citation statement)

References 27 publications

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“…FEM is a method of choice when dealing with complex geometries, sophisticated non-linear material properties, or cases where material parameters would be impossible to obtain using experimental tests. It is also important to improve the current methodology used for BVS ( 22 ) since the major problem is to accurately describe the mechanical behavior of bioresorbable polymers ( 4 , 23 ). It was shown that FEM can be efficiently used for the prediction of structure degradation during cyclic loading ( 19 ), or the construction of new material models ( 24 – 28 ).…”

Section: Introductionmentioning

confidence: 99%

Application of in silico Platform for the Development and Optimization of Fully Bioresorbable Vascular Scaffold Designs

Milošević

Anic

Nikolić

et al. 2021

Front. Med. Technol.

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Bioresorbable vascular scaffolds (BVS), made either from polymers or from metals, are promising materials for treating coronary artery disease through the processes of percutaneous transluminal coronary angioplasty. Despite the opinion that bioresorbable polymers are more promising for coronary stents, their long-term advantages over metallic alloys have not yet been demonstrated. The development of new polymer-based BVS or optimization of the existing ones requires engineers to perform many very expensive mechanical tests to identify optimal structural geometry and material characteristics. in silico mechanical testing opens the possibility for a fast and low-cost process of analysis of all the mechanical characteristics and also provides the possibility to compare two or more competing designs. In this study, we used a recently introduced material model of poly-l-lactic acid (PLLA) fully bioresorbable vascular scaffold and recently empowered numerical InSilc platform to perform in silico mechanicals tests of two different stent designs with different material and geometrical characteristics. The result of inflation, radial compression, three-point bending, and two-plate crush tests shows that numerical procedures with true experimental constitutive relationships could provide reliable conclusions and a significant contribution to the optimization and design of bioresorbable polymer-based stents.

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Section: Introductionmentioning

confidence: 99%

Application of in silico Platform for the Development and Optimization of Fully Bioresorbable Vascular Scaffold Designs

Milošević

Anic

Nikolić

et al. 2021

Front. Med. Technol.

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Investigation of Drug Eluting Stents Performance Through in silico Modeling

Loukas

Pleouras

Karanasiou

et al. 2020

8th European Medical and Biological Engineering Conference

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Influences of plaque eccentricity and composition on the stent–plaque–artery interaction during stent implantation

Wei

Chen

2018

Biomech Model Mechanobiol

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This work aims to investigate the effects of plaque eccentricity and composition on the stent performance and stress distributions of plaque and artery during stenting by the finite element method. Three-dimensional stent-plaque-artery models for plaques with five different eccentricities and four different compositions were simulated, and the influences on stent recoil, stent plastic strain, stent foreshortening, stress distributions of artery and plaque, and lumen gain were studied. The results show that greater plaque eccentricity leads to greater stent recoil, stent plastic strain, stent foreshortening, maximum von Mises stresses of artery and plaque, and volume percentage of plaque in higher stress. Plaque composition exerts a great effect on all indices except the maximum von Mises stress of artery. The lipid pool declines stent recoil, but increases the maximum plastic strain of stent due to its softness, while the fibrous cap reduces stent foreshortening. Because of the existence of fibrous cap/calcified zones, plaque with greater eccentricity and higher mixture of components is more vulnerable during stenting process; thus, a larger expanding pressure should be carefully applied and a slightly longer stent should be used. The present study suggests that the real plaque geometry and composition in numerical simulations should be considered as an integral part of stent design and development, also is useful in enhancing our understanding of the mechanics of stent-plaque-artery interaction during stent implantation to improve the stent's long-term clinical outcome.

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The importance of vessel factors for stent deployment in diseased arteries

Cited by 5 publications

References 27 publications

Application of in silico Platform for the Development and Optimization of Fully Bioresorbable Vascular Scaffold Designs

Application of in silico Platform for the Development and Optimization of Fully Bioresorbable Vascular Scaffold Designs

Investigation of Drug Eluting Stents Performance Through in silico Modeling

Influences of plaque eccentricity and composition on the stent–plaque–artery interaction during stent implantation

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