The important role of ghrelin on gastric contraction in &lt;i&gt;Suncus murinus&lt;/i&gt;

Takemi, Shota; Sakata, Ichiro; Kuroda, Kayuri; Miyano, Yuki; Mondal, Anupon; Sakai, Takafumi

doi:10.1507/endocrj.64.s11

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…Motilin and ghrelin belong to the same peptide family, and these hormones play an important role in the regulation of gastrointestinal motility. Ghrelin and motilin can synergistically stimulate strong gastric contraction in vitro and in vivo 373 . Motilin and the combination of motilin and ghrelin stimulated gastric acid secretion in the shrew Suncus through the histamine-mediated pathway 374 .…”

Section: Current Development and Application Of Therapeutic Peptides ...mentioning

confidence: 99%

Therapeutic peptides: current applications and future directions

Wang

Zhang

et al. 2022

Sig Transduct Target Ther

909

595

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Peptide drug development has made great progress in the last decade thanks to new production, modification, and analytic technologies. Peptides have been produced and modified using both chemical and biological methods, together with novel design and delivery strategies, which have helped to overcome the inherent drawbacks of peptides and have allowed the continued advancement of this field. A wide variety of natural and modified peptides have been obtained and studied, covering multiple therapeutic areas. This review summarizes the efforts and achievements in peptide drug discovery, production, and modification, and their current applications. We also discuss the value and challenges associated with future developments in therapeutic peptides.

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Section: Current Development and Application Of Therapeutic Peptides ...mentioning

confidence: 99%

Therapeutic peptides: current applications and future directions

Wang

Zhang

et al. 2022

Sig Transduct Target Ther

909

595

View full text Add to dashboard Cite

show abstract

“…There are a few reports examining the relationship between motilin and ghrelin [37,38]. In the present study, human MLNR Tg mice were administered EM by the central route and the plasma level of acyl-ghrelin was examined at 1 h post-dose.…”

Section: Discussionmentioning

confidence: 98%

Effects of Motilin Receptor Agonists and Ghrelin in Human motilin receptor Transgenic Mice

Kawamura

Matsuura

Miyake

et al. 2019

IJMS

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Gastrointestinal motility is regulated by neural factors and humoral factors. Both motilin and ghrelin improve gastrointestinal motility, but many issues remain unclear. We prepared human motilin receptor transgenic (Tg) mice and performed experiments evaluating the effects of motilin, erythromycin (EM), and ghrelin. EM and ghrelin promoted gastric emptying (GE) when administered either peripherally or centrally to Tg mice. Atropine (a muscarinic receptor antagonist) counteracted GE induced by centrally administered EM, but not that induced by peripherally administered EM. The administration of EM in this model promoted the effect of mosapride (a selective serotonin 5-hydroxytryptamine 4 (5-HT4) receptor agonist), and improved loperamide (a μ-opioid receptor agonist)-induced gastroparesis. The level of acyl-ghrelin was significantly attenuated by EM administration. Thus, we have established an animal model appropriate for the evaluation of motilin receptor agonists. These data and the model are expected to facilitate the identification of novel compounds with clinical potential for relieving symptoms of dyspepsia and gastroparesis.

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“…For example, Atractylodes lancea rhizome stimulates gastric emptying by inhibiting the dopamine D2 receptor [4]. Ghrelin, a peptide hormone produced in the stomach, is known to function in the regulation of gastric contraction in humans and rodents [11]. Cinnamon extracts induced ghrelin gene expression in human cells [5].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Juzen-taiho-to against vincristine-induced toxicity in dogs

Shinohara

Nishino

Yamanaka

et al. 2019

The Journal of Veterinary Medical Science

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Vincristine, one of the anti-cancer drugs used in veterinary practice, has adverse hematological and gastrointestinal effects in dogs. Juzen-taiho-to is a traditional Chinese medicine used for patients with anorexia in human medicine. However, the protective effects of Juzen-taiho-to against anti-cancer drug-induced toxicity in dogs have not been investigated. We therefore examined whether the administration of Juzen-taiho-to to dogs affects gastric motility, and vincristine-induced gastrointestinal and hematological toxicity. The study was composed of three trials. In the first trial, Juzen-taiho-to (450 mg/kg/day) was orally administered to five dogs. In the second and third trials, vincristine (0.75 mg/m 2) was intravenously administered to each dog in the absence or presence of Juzen-taiho-to (450 mg/kg/day). During these trials, gastric motility and blood parameters were assessed. Juzen-taiho-to increased gastric motility and improved vincristine-induced gastrointestinal, but not hematological, adverse effects in dogs. This study suggested that Juzen-taiho-to may be applicable for gastrointestinal care in dogs receiving chemotherapy.

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The important role of ghrelin on gastric contraction in <i>Suncus murinus</i>

Cited by 3 publications

References 15 publications

Therapeutic peptides: current applications and future directions

Therapeutic peptides: current applications and future directions

Effects of Motilin Receptor Agonists and Ghrelin in Human motilin receptor Transgenic Mice

Efficacy of Juzen-taiho-to against vincristine-induced toxicity in dogs

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