The Important Role of TMPRSS2 Gene in Covid-19 and Prostate Cancer: In Silico Approach

Kalkanli, Arif; Kirkik, Duygu; Bostancı, Emre; Taş, Sevgi Kalkanlı

doi:10.1590/1678-4324-2021200785

Cited by 2 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Binding of virus is accompanied by preparing the S2 subunit of spike protein with host trans-membrane serine protease-2 (TMPRSS2) to allow viral entry into the cell leading to endocytic replication of the virus to generate virions [13]. A recent insilico study aimed at understanding the relation of prostate cancer and COVID-19 have highlighted the role of variations observed mainly in ACE-2 and TMPRSS2 genes [14].…”

Section: Structure and Life Cycle Sars-cov-2mentioning

confidence: 99%

SARS-CoV-2 Variants Impact on Key Signaling Pathways Metamorphoses into Severity

Misra,

Hora,

Ginwal

et al. 2023

Braz. arch. biol. technol.

View full text Add to dashboard Cite

The Severe Acute Respiratory Syndrome Coronavirus-2 causes a dreadful Coronavirus Disease namely COVID-19. Respiratory system is the primary target of the virus. It also impairs other major organs such as kidney, heart, liver, brain etc. Multiple novel variants of SARS-CoV-2 have appeared since the SARS-CoV-2 pandemic occurred which are linked to increased virulence, disease transmission and severity. The virus attacks the host signalling pathways to maintain a favourable environment for its spread. The present study focuses on the comprehensive analysis of major signaling pathways affected due to several variants of SARS-CoV-2 leading to abnormalities in cell growth and differentiation. The information was curated from the weblinks of several platforms like WHO, CDC, PANGO, Nextstrain clade and GISAID clade. The data on signaling pathways and comorbidities was generated by screening of different research and review articles. SARS-CoV-2 consolidates the cytoskeleton of the host for effective cell invasion and modulates the transcription processes to enable the translation of viral protein(s). These events lead to significant increase and prolonged hyper inflammation. Further, a decreased interferon (IFN) response along with increased interleukin production leading to cytokine storm is observed. Deregulation of interleukin pathways, TNF-α signalling through JAK/STAT-3 signalling, MAPK1, mTOR, PI3K are few other signalling pathways that are affected on SARS-CoV-2 infection. This review represents a comprehensive analysis of the vigorous life cycle of SARS CoV-2, its different variants affecting host signalling pathways which eventually cause dysfunctioning of several organs and development of comorbidities.

show abstract

Section: Structure and Life Cycle Sars-cov-2mentioning

confidence: 99%

SARS-CoV-2 Variants Impact on Key Signaling Pathways Metamorphoses into Severity

Misra,

Hora,

Ginwal

et al. 2023

Braz. arch. biol. technol.

View full text Add to dashboard Cite

show abstract

“…The study was carried out in silico , using existing, open access cancer omics databases and bioinformatics tools whose algorithms have been upgraded to provide well-grounded results based on real scientific evidence of clinical value. Two similar studies carried out by Hoang et al [ 35 ] and Kalkanli et al [ 36 ] have also performed an assessment of the susceptibility of PRAD patients towards COVID-19. However, these two studies were focused towards the expression analysis of ACE2 and TMPRSS2 rather than CXCL10 , which is an important inflammatory cytokine that plays an active role in cancer metastasis [ 37 - 39 ].…”

Section: Introductionmentioning

confidence: 99%

A systemic study on the vulnerability and fatality of prostate cancer patients towards COVID-19 through analysis of the TMPRSS2, CXCL10 and their co-expressed genes

Raza¹,

Mizan²

2022

Genomics Inform

View full text Add to dashboard Cite

A pandemic of respiratory disease named coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is reported prostate cancer patients are susceptible to COVID-19 infection. To understand the possible causes of prostate cancer patients' increased vulnerability and mortality from COVID-19 infection, we focused on the two most important agents, transmembrane protease serine subtype 2 (TMPRSS2) and the C-X-C motif 10 (CXCL10). When SARS-CoV-2 binds to the host cell via S protein–angiotensin-converting enzyme-2 receptor interaction, TMPRSS2 contributes in the proteolytic cleavage of the S protein, allowing the viral and cellular membranes to fuse. CXCL10 is a cytokine found in elevated level in both COVID-19 and cancer-causing cytokine storm. We discovered that TMPRSS2 and CXCL10 are overexpressed in prostate cancer and COVID-19 using the UALCAN and GEPIA2 datasets. The functional importance of TMPRSS2 and CXCL10 in prostate cancer development was then determined by analyzing the frequency of genetic changes in their amino acid sequences using the cBioPortal online portal. Finally, we used the PANTHER database to examine the pathology of the targeted genes. We observed that TMPRSS2 and CXCL10, together with their often co-expressed genes, are important in the binding activity and immune responses in prostate cancer and COVID-19 infection, respectively. Finally, we found that TMPRSS2 and CXCL10 are two putative biomarkers responsible for the increased vulnerability and fatality of prostate cancer patients to COVID-19.

show abstract

The Important Role of TMPRSS2 Gene in Covid-19 and Prostate Cancer: In Silico Approach

Cited by 2 publications

References 34 publications

SARS-CoV-2 Variants Impact on Key Signaling Pathways Metamorphoses into Severity

SARS-CoV-2 Variants Impact on Key Signaling Pathways Metamorphoses into Severity

A systemic study on the vulnerability and fatality of prostate cancer patients towards COVID-19 through analysis of the TMPRSS2, CXCL10 and their co-expressed genes

Contact Info

Product

Resources

About