The improvement effect of gastrodin on LPS/GalN-induced fulminant hepatitis via inhibiting inflammation and apoptosis and restoring autophagy

Lv, Hongming; Liu, Yuanyuan; Zhang, Boxi; Zheng, Yuwei; Ji, Hong; Li, Shize

doi:10.1016/j.intimp.2020.106627

Cited by 21 publications

(14 citation statements)

References 48 publications

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“…Gastrodin could attenuate inflammatory response and cell migration via Notch-1 pathway in activated microglia (Yao et al, 2021). In addition, in the nervous system, gastrodin alleviated the neurocognitive dysfunction of aged mice via suppressing neuroinflammation and promoted the myelination of the central nervous system (CNS) (Lv et al, 2020). Notably, a previous study indicated the nephroprotective effects of gastrodin against lead-induced oxidative stress and inflammation in mice, which was consistent with our findings.…”

Section: Discussionsupporting

confidence: 91%

Gastrodin provides neuroprotection in models of traumatic brain injury via Nrf2 signaling pathway

Wang

Dong

2021

qas

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Gastrodin is one of the main active components of Gastrodia elata and has significant therapeutic value for various nervous system diseases. Its medicinal properties include smooth muscle relaxation, anti-necrosis, anti-aging, and anti-apoptosis effects. However, its possible effects on traumatic brain injury (TBI) are still unclear. In this study, the effects of gastroditin on TBI rats were investigated. The results proved that gastrodin had neuroprotective effect on TBI through alleviating brain deficits, decreasing brain water content, inhibiting neuronal apoptosis, and suppressing oxidative stress in brain tissues of TBI rats. Mechanically, gastrodin upregulated the expression of Nrf2 downstream proteins, suggesting the activation of Nrf2 pathway in brain tissues of TBI rats. In conclusion, gastrodin provided neuroprotection in TBI rats via Nrf2 pathway.

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Section: Discussionsupporting

confidence: 91%

Gastrodin provides neuroprotection in models of traumatic brain injury via Nrf2 signaling pathway

Wang

Dong

2021

qas

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“…40,41 Autophagy reduces the secretion of IL-1β by inhibiting inflammasome activation. 42,43 Activation of autophagy can also inhibit the secretion of TNF-α and IL-6. 44 As a classic damage-related model molecule, HMGB1 mainly regulates autophagy by binding to Beclin1.…”

Section: Discussionmentioning

confidence: 99%

Sophoridine inhibits endotoxin-induced acute lung injury by enhancing autophagy of macrophage and reducing inflammation

Liu

Tang

et al. 2022

Journal of Leukocyte Biology

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Acute lung injury (ALI) is characterized by uncontrolled inflammation, which can lead to respiratory distress syndrome and cause patient death. In this study, we sought to determine the role of sophoridine, a compound purified from sophora, in ALI. A mouse model of ALI was established by treating mice with LPS through nonexposed tracheal instillation. After LPS‐induced mice were treated with sophoridine, LPS‐induced alveolar wall thickening, alveolar interstitial inflammatory exudation and thickening, and the degree of pulmonary edema were found to be inhibited. Macrophages play an important role in inflammation, and in vitro experiments have demonstrated that sophoridine reduces the LPS‐induced expression of inflammatory factors by macrophages, suggesting that sophoridine may inhibit lung inflammation in LPS‐treated mice through reduces the secretion of inflammatory factors. Further, treatment with sophoridine up‐regulated autophagy in macrophage cells in vitro and mouse lung tissues in vivo. LPS can bind to TLRs and activate the MyD88/NF‐κB pathways, leading to increased inflammation in the pathogenesis of ALI. Our findings revealed that sophoridine down‐regulated the expression of TLR4/MyD88/NF‐κB and mTOR mRNA and protein in mouse pulmonary tissue. Collectively, these findings indicate that sophoridine may inhibit LPS‐induced ALI by enhancing autophagy of macrophages and reducing inflammation.

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“…It has been reported that GTD inhibits the activation of NF-kB pathway in the LPS/GalN-induced fulminant hepatitis ( Lv et al, 2020 ). Since GTD promotes the expression of IFN-I, which targets the common signaling pathway between DNA and RNA viruses, then we screened the common signaling pathway that produces IFN-I.…”

Section: Discussionmentioning

confidence: 99%

“…Gastrodin (GTD), also named as 4-hydroxybenzyl alcohol-4-O-β- d -glucopyranoside, is a phenolic glycoside which is the glucoside of gastrodigenin ( Liu et al, 2018 ). GTD is extracted from Gastrodia elata Blume and possesses the anti-apoptosis, and anti-inflammatory activities ( Lv et al, 2020 ). As far, the research on GTD is mostly focused on its effect on the central nervous system ( Zuo et al, 2016 ; Liu et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

“…Numerous studies have been reported that GTD possesses anti-oxidative stress, anti-inflammatory, and neuroprotective effects, which can relieve a broad range of CNS-related diseases, such as epilepsy, Alzheimer’s disease, Parkinson’s disease, affective disorders, cerebral ischemia/reperfusion. It has been reported that GTD acts as a protective molecular in LPS/GalN-induced fulminant hepatitis ( Lv et al, 2020 ). GTD inhibits hepatocyte apoptosis through the inhibition of NLRP3 inflammasome and NF-κB activation, and the recovery of AMPK/ACC/autophagy ( Sun et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Gastrodin Inhibits Virus Infection by Promoting the Production of Type I Interferon

Zhou

et al. 2021

Front. Pharmacol.

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Type I interferon (IFN-I) plays a critical role in the antiviral immune response. However, viruses have developed different strategies to suppress the production of IFN-I for its own escape and amplification. Therefore, promoting the production of IFN-I is an effective strategy against virus infection. Gastrodin (GTD), a phenolic glucoside extracted from Gastrodia elata Blume, has been reported to play a protective role in some central nervous system -related diseases and is beneficial for the recovery of diseases by inhibiting inflammation. However, the effect of GTD on virus infection is largely unknown. Here we found GTD treatment increased the survival rate of mice infected with vesicular stomatitis virus (VSV) or herpes simplex virus-1 (HSV-1). The production of IFN-I was increased in GTD-treated mice or macrophages compared to the control group, during virus infection. Furthermore, the activation of interferon regulatory factor 3 (IRF3) was promoted by GTD in macrophages upon VSV and HSV-1 infection. Our results demonstrated that GTD could inhibit the VSV and HSV-1 infection by promoting the production of IFN-I in macrophages and might provide an effective strategy against virus infection.

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The improvement effect of gastrodin on LPS/GalN-induced fulminant hepatitis via inhibiting inflammation and apoptosis and restoring autophagy

Cited by 21 publications

References 48 publications

Gastrodin provides neuroprotection in models of traumatic brain injury via Nrf2 signaling pathway

Gastrodin provides neuroprotection in models of traumatic brain injury via Nrf2 signaling pathway

Sophoridine inhibits endotoxin-induced acute lung injury by enhancing autophagy of macrophage and reducing inflammation

Gastrodin Inhibits Virus Infection by Promoting the Production of Type I Interferon

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