The Improvement of Short- and Long-term Memory of Young Children by BF-7

Effect of a Fibroin Enzymatic Hydrolysate on Memory Improvement: A Placebo-Controlled, Double-Blind Study

“…Previous studies have used daily doses of 200 or 400 mg of FPEH. The current study confirmed the results of previous studies regarding the ability of FPEH to enhance memory and learning [ 5 , 6 , 7 , 8 , 9 , 10 ] This study extended the finding of efficacy for memory improvement from FPEH in a healthy population with ages as high as 92 years. Cognitive decline, specifically memory loss, is frequently associated with natural aging [ 17 ].…”

“…In recent years, it has been reported that a specifically prepared, proprietary silk fibroin protein enzymatic hydrolysate (FPEH) improves cognitive function in normal, healthy humans [ 5 , 6 , 7 , 8 , 9 , 10 ]. The enzymatic hydrolysis results in short strands of the protein with a molecular weight range of 500–5000 daltons.…”

“…Eight separate, controlled human studies have found that FPEH at doses of 200–400 mg daily administered acutely or for 3–16 weeks significantly improved mental function from baseline and placebo groups by validated measurements [ 5 , 6 , 7 , 8 , 9 , 10 ]. Furthermore, an animal study showed improvements or restoration of various memory deficits by the oral administration of FPEH [ 11 ].…”

“…The purpose of the current study is to evaluate the dose-dependent effectiveness of the FPEH for memory improvement in healthy adults, using a validated memory test. Doses of 280, 400 and 600 mg/day were given, with the 600 mg dose being higher than doses used in previous studies [ 5 , 6 , 7 , 8 , 9 , 10 ]. The study assessed memory effects over a wide age range under identical experimental conditions and was designed to validate results of previous studies.…”

Identification and applications of neuroactive silk proteins: a narrative review

“…Chae et al have reported that administration of BF-7 for one month improves learning and memory in healthy high school students (Chae et al, 2004). Clinical studies also showed that BF-7 improves short-term and long-term memories, cognitive flexibility, and attention in healthy school children (Kim et al, 2009;Kim et al, 2010a). A double-blind, placebo-controlled study reported that three weeks administration of BF-7 (200 and 400 mg) improved cognitive function in healthy adults in a dose-dependent manner (Lee et al, 2004).…”