The Improvement of the Anticancer Effect of a Novel Compound Benzoic Acid, 2-Hydroxy-, 2-d-ribofuranosylhydrazide (BHR) Loaded in Solid Lipid Nanoparticles

Wang, Mei; Qin, Lili; Li, Kun; Zhu, Rongrong; Wang, Wenrui; Wang, Shilong

doi:10.1208/s12249-012-9862-8

Cited by 12 publications

(6 citation statements)

References 32 publications

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“…Among the above, SLNs may be an alternative drug carrier system that offers several advantages conferred by their colloidal dimensions, including: easy incorporation of both lipophilic and hydrophilic drugs; improved biocompatibility; flexible surface functionality; nanoscopic structure; monodispersity; and high encapsulation efficiency (Muller and Keck 2010; Alpiaz et al 2008; Carneiro et al 2012; Jaspart et al 2005; Shuhendler et al 2012; Wang et al 2012; Yang et al 2012). …”

Section: Introductionmentioning

confidence: 99%

Assessment of lactoferrin-conjugated solid lipid nanoparticles for efficient targeting to the lung

2015

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The aim of the present study was to develop a target oriented drug delivery system for the lungs. Lactoferrin (Lf)-coupled solid lipid nanoparticles (SLNs) bearing rifampicin was prepared by a solvent injection method. The prepared nanoparticles were characterized for shape, particle size, polydispersity and percentage drug entrapment. An optimized formulation was then studied for its in vivo performance in animals and to determine its targeting efficiency. It was observed that, upon coupling with Lf, the size of SLNs increased while the percent entrapment efficiency decreases. In in vitro release, determined by a dialysis technique, analysis showed that uncoupled SLNs exhibited higher drug release as compared to coupled SLNs. An in vivo biodistribution study shows 47.7 ±0.4 drug uptakes by the lungs, which was 3.05 times higher in comparison to uncoupled SLNs. These biodistribution studies are further supported by the fluorescence study that revealed enhanced uptake of Lf-coupled SLNs in the lung. From the presented results, it can be concluded that Lf-coupled SLNs enhanced drug uptake in the lung. Moreover, lactoferrin is an efficient molecule that can be used for targeting active agents directly to the lung.

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Section: Introductionmentioning

confidence: 99%

Assessment of lactoferrin-conjugated solid lipid nanoparticles for efficient targeting to the lung

2015

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“…The treatment of 293T and Hela cells with BHR-SLNs demonstrated that BHR-SLNs were less toxic than normal cells, while more effective in antitumor potency compared with the BHR drug alone. These results showed that BHR-SLNs could be considered as a promising antitumor drug system for a range of new therapeutic applications (Wang et al, 2012b). as surfactant.…”

Section: In Vitro Studiesmentioning

confidence: 88%

Solid Lipid Nanoparticles as Oral Delivery Systems of Phenolic Compounds: Overcoming Pharmacokinetic Limitations for Nutraceutical Applications

Nunes

Madureira

Campos

et al. 2015

Critical Reviews in Food Science and Nutrition

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Drug delivery systems, accompanied by nanoparticle technology, have recently emerged as prominent solutions to improve the pharmacokinetic properties, namely bioavailability, of therapeutic and nutraceutical agents. Solid lipid nanoparticles (SLNs) have received much attention from researchers due to their potential to protect or improve drug properties. SLNs have been reported to be an alternative system to traditional carriers, such as emulsions, liposomes, and polymeric nanoparticles. Phenolic compounds are widespread in plant-derived foodstuffs and therefore abundant in our diet. Over the last decades, phenolic compounds have received considerable attention due to several health promoting properties, mostly related to their antioxidant activity, which can have important implications for health. However, most of these compounds have been associated with poor bioavailability being poorly absorbed, rapidly metabolized and eliminated, which compromises its biological and pharmacological benefits. This paper provides a systematic review of the use of SLNs as oral delivery systems of phenolic compounds, in order to overcome pharmacokinetic limitations of these compounds and improved nutraceutical potential. In vitro studies, as well as works describing topical and oral treatments will be revisited and discussed. The classification, synthesis, and clinical application of these nanomaterials will be also considered in this review article.

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“…36 The zeta potential of NCNLCs was distributed between −3.5 mV and −5.2 mV, a lightly negative charge, suggesting good stability and high cellular uptake, and also facilitating the delivery of NCNLCs to the negatively charged cancer cells. 37 The DEE and DLC of NG encapsulated in NCNLCs were 91.77±0.48%, and 6.96±0.02%, separately ( Figure 2C). In order to investigate the influence of CSO as liquid lipids, the morphology of NCNLCs was also determined in Figure 2A and B, displayed as spherical particles with around 50 nm, which was essentially in agreement with the results of photon correlation spectroscopy analysis.…”

Section: Preparation and Characterization Of Ncnlcsmentioning

confidence: 94%

<p>Formulation, Preparation and Evaluation of Nanostructured Lipid Carrier Containing Naringin and Coix Seed Oil for Anti-Tumor Application Based on “Unification of Medicines and Excipients”</p>

Zhu¹,

Huang²,

Zhang³

et al. 2020

DDDT

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Background: "Unification of medicines and excipients" is the special principle which means fatty oil with pharmacodynamic activity derived from traditional Chinese medicine are taken as liquid lipids in perparation for dual-drug delivery, which improve the treatment effect and reduce unnecessary excipients. Purpose: The aim of this study was to prepare a nanostructured lipid carrier (NLC) with naringin (NG) containing coix seed oil (CSO) as liquid lipid based on the theory (NCNLC) in order to achieve synergistic antitumor activity against hepatocellular carcinoma. Methods: We developed NCNLCs using ultrasonic melt-emulsification method. The antitumor effect in vivo/in vitro and drug release ability were compared to NLC prepared with conventional liquid lipids: neodecanoate triglycerides (NDNLC) and oleic acid (NONLC). Results: Transmission electron microscopy showed that NCNLCs had a well-defined spherical shape, small size, and narrow polydispersity index. Importantly, the release of drugs from NDNLCs and NONLCs was slower than NCNLCs. In the cell study, the result showed a significantly greater antiproliferative effect towards HepG2 cells, and the half-maximal inhibitory concentration of NCNLCs was 3.24-fold, 1.70-fold and 1.52-fold lower to that of free drug, NDNLCs and NONLCs, respectively. Moreover, NCNLCs significantly induced HepG2 cells apoptosis by being 2.12-fold and 9.28-fold higher to that of NDNLCs and NONLCs, respectively. In the study of antitumor efficacy in vivo, the synergistic effect of NCNLCs formulation showed markedly enhanced antitumor efficacy in a xenograft model of liver cancer. Conclusion: The advantages of "unification of medicines and excipients" in formulation characters, drug release and synergistic antitumor effect provide a new idea for the application of the fatty oil of traditional Chinese medicine in the nano-drug delivery for cancer therapy.

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The Improvement of the Anticancer Effect of a Novel Compound Benzoic Acid, 2-Hydroxy-, 2-d-ribofuranosylhydrazide (BHR) Loaded in Solid Lipid Nanoparticles

Cited by 12 publications

References 32 publications

Assessment of lactoferrin-conjugated solid lipid nanoparticles for efficient targeting to the lung

Assessment of lactoferrin-conjugated solid lipid nanoparticles for efficient targeting to the lung

Solid Lipid Nanoparticles as Oral Delivery Systems of Phenolic Compounds: Overcoming Pharmacokinetic Limitations for Nutraceutical Applications

<p>Formulation, Preparation and Evaluation of Nanostructured Lipid Carrier Containing Naringin and Coix Seed Oil for Anti-Tumor Application Based on “Unification of Medicines and Excipients”</p>

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