The in‐hospital burden of hidradenitis suppurativa in patients with inflammatory bowel disease: a decade nationwide analysis from 2004 to 2014

Ramos‐Rodriguez, Alvaro J.; Timerman, Dmitriy; Khan, Ali; Bonomo, L; Hunjan, Manrup K.; Lemor, Alejandro

doi:10.1111/ijd.13932

Cited by 26 publications

(29 citation statements)

References 15 publications

(36 reference statements)

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“…The 3% prevalence of comorbidity in inflammatory bowel disease (441 cases in 13,548 patients) indicates a higher occurrence than in the Swedish population, even if the aggregated reference data did not allow for age-or sex-adjusted comparison. This finding is in line with inflammatory bowel disease being a frequently reported comorbid condition in patients with HS and with the suggested common mechanism of disease [1,5,21]. The 8% prevalence of type 2 diabetes reflects the previously reported comorbidity in metabolic syndrome [1,2,8].…”

Section: Discussionsupporting

confidence: 86%

“…Furthermore, HS is more common in women (> 2: 1 ratio) and usually presents after puberty, something which could also be shown in a recent big American study [4]. Inflammatory bowel disease [5] and metabolic syndrome, including type 2 diabetes [6], are frequently reported comorbid conditions in patients with HS. Overweight, obesity, and smoking are associated with HS, and have been shown to correlate with the severity and prognosis of the disease [7,8].…”

Section: Introductionmentioning

confidence: 62%

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Hidradenitis Suppurativa in Sweden: A Registry-Based Cross-Sectional Study of 13,538 Patients

et al. 2020

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Background: Hidradenitis suppurativa (HS) is a chronic, inflammatory skin condition with nodules and fistula formation and scarring. It is a debilitating disease with a severe negative impact on quality of life. There is a need for increased knowledge about the social and lifestyle characteristics of patients with HS in general, and pregnant women in particular. Objectives: The aims of this study were to investigate and describe social characteristics and comorbidity in all HS patients in Sweden as well as to study the prevalence of lifestyle factors associated with negative impact on health and pregnancy in Swedish pregnant women with HS. Methods: A registry-based cross-sectional study was performed by record linkage between Swedish registers covering the entire population. A cohort of 13,538 HS patients diagnosed with HS in specialised care during the years 2001–2014 and a subgroup of 1,368 HS patients who had undergone pregnancy during 2010–2015 were defined and described. Aggregated public data on the entire Swedish population and all pregnancies in 2014 were described for reference. Results: The HS population had an average age of 44 years on December 31, 2014. The prevalence of HS was 0.14%. In comparison to the Swedish reference population the HS patients were more often women, unmarried (36 vs. 44% married), and had lower education (68 vs. 82% with an upper-secondary school degree or higher) and lower income (39 vs. 16% made SEK <100,000 a year). Comorbidity was 3% for inflammatory bowel disease and 8% for type 2 diabetes. The subgroup analysis showed high prevalence of overweight, obesity, and smoking in pregnant women with HS. Conclusions: The results from this comprehensive characterisation of Swedish HS patients may be used to improve preventive measures, information, and care for this vulnerable group.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 62%

Hidradenitis Suppurativa in Sweden: A Registry-Based Cross-Sectional Study of 13,538 Patients

et al. 2020

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“…Interestingly, for both Crohn’s disease and ulcerative colitis the risk of new-onset disease was significantly increased among patients with HS. Most recently, a 2018 retrospective cohort study (Bonomo et al, 2018) investigated the in-hospital burden of HS patients with inflammatory bowel disease (IBD) and found that HS patients with IBD were significantly younger and predominantly African American females. These individuals were significantly more likely to be smokers, to be obese, and to have diabetes mellitus, depression, and anemia.…”

Section: Resultsmentioning

confidence: 99%

Comorbidities of hidradenitis suppurativa: A review of the literature

Cartron

Driscoll

2019

International Journal of Women's Dermatology

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BackgroundHidradenitis suppurativa (HS) is a chronic inflammatory skin condition that affects the follicular portion of folliculopilosebaceous units. It causes painful nodules, abscesses, and draining sinus tracts throughout multiple regions of the body. HS primarily affects women; the overall HS prevalence in women is three times that in men. Although cutaneous disease itself causes substantial morbidity, recent evidence has shown that HS is a systemic inflammatory disease with multiple associated comorbidities.ObjectiveA review of the literature was conducted to elucidate existing information on this topic to assist in clinical decision-making for dermatologists.MethodsA review of the literature using the PubMed database was conducted with the search term “hidradenitis suppurativa comorbidities”. The search was conducted from March 3, 2019 to March 20, 2019, and yielded 55 articles, case reports, and reviews.ResultsMetabolic and cardiovascular comorbidities were the most commonly associated with HS. HS has a significant comorbidity burden beyond the skin, including metabolic, cardiovascular, endocrine, gastrointestinal, rheumatologic, and psychiatric disorders, which collectively decrease the quality of life of patients.ConclusionsDermatologists should be aware of these associations to encourage appropriate screening and referral for management of these disorders.

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“…[6][7][8] The onset of HS typically occurs after puberty, 9 and young females are more likely to be affected. 10,11 While variations in the prevalence between different sexes and ages in HS are documented in literature, race-specific prevalence has started to garner attention from the scientific community. 12 Recently, studies examining HS race-specific prevalence concluded that the majority (66.7%) of those affected by HS are Caucasians.…”

Section: Introductionmentioning

confidence: 99%

Race-Specific Prevalence of Hidradenitis Suppurativa

2020

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Hidradenitis suppurativa (HS) is a chronic, inflammatory disease affecting approximately 1% of the global population. While age- and sex-specific prevalence of HS is well documented in literature, few studies have explored trends in racial predilections for HS. The objective of this study is to investigate the race-specific prevalence of HS. MEDLINE and EMBASE searches were conducted in the OVID database. Keywords included variations of “race,” “ethnicity,” “country,” “prevalence,” and “Hidradenitis suppurativa.” Studies were included if they were written in English or French, conducted on human participants, and had data on HS and race-specific prevalence. Meta-analyses, systematic and literature reviews, and irrelevant articles were excluded. Thirty-nine out of 184 articles met the inclusion criteria after abstract and full-text screening. Population distribution was scaled according to country-specific demographics reports. These demographic reports were extracted from each country’s national statistics report. The average HS prevalence rates were highest in African American populations (1.3%), lowest in Hispanics/Latinos (0.07%), and intermediate amongst Caucasian populations (0.75%). Total prevalence in all other ethnic groups (0.17%) was minor in comparison to African American and Caucasian populations. Since the highest rates of HS were found among African American population, literature has highlighted the possibility of a genetic etiology in HS development. However, further literature examining race-specific prevalence of HS internationally is required to accurately assess the frequency and underlying etiology of HS among varying racial populations.

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The in‐hospital burden of hidradenitis suppurativa in patients with inflammatory bowel disease: a decade nationwide analysis from 2004 to 2014

Abstract: This large-scale study strengthens the evidence that these two inflammatory conditions are truly associated and establishes their joint effect on overall morbidity, mortality, and resource utilization.

Cited by 26 publications

References 15 publications

Hidradenitis Suppurativa in Sweden: A Registry-Based Cross-Sectional Study of 13,538 Patients

Hidradenitis Suppurativa in Sweden: A Registry-Based Cross-Sectional Study of 13,538 Patients

Comorbidities of hidradenitis suppurativa: A review of the literature

Race-Specific Prevalence of Hidradenitis Suppurativa

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