The in vivo blood compatibility of bio-inspired small diameter vascular graft: effect of submicron longitudinally aligned topography

Liu, Ruiming; Qin, Yuansen; Wang, Huijin; Zhao, Yong; Hu, Zhiqiang; Wang, Shenming

doi:10.1186/1471-2261-13-79

Cited by 33 publications

(20 citation statements)

References 43 publications

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“…30 A stable jet was formed when 13% PU (w/w) prepared in a mixture of THF and DMF (5:5, v:v). Voltages were supplied in the range from 20 to 25 kV at the distance of 20 cm with the feed rate of 0.7 mL/h.…”

Section: Coaxial Electrospinningmentioning

confidence: 99%

Preparation of Dipyridamole/Polyurethane Core–Shell Nanofibers by Coaxial Electrospinning for Controlled-Release Antiplatelet Application

Qin¹,

Liu²,

Zhao³

et al. 2016

j nanosci nanotechnol

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To improve the hemocompatibility of blood-compatible materials, antiplatelet drug dipyridamole (DIP) was encapsulated in polyurethane (PU) to form core-shell nanofibers by coaxial electrospinning method. PU solution and DIP/polycaprolactone compound solution served as shell and core fluid, respectively. Uniform fibers without beads, were fabricated and a clear core-shell structure was generated. The diameter of nanofibers and core structure increased with an increase in the flow rate of the core solution. X-Ray diffraction and differential scanning calorimeter showed that the whole system formed solid dispersion and DIP was dispersed in polymer matrix in an amorphous state. In vitro drug release test demonstrated that releasing curve had two phases consisting of initial burst release and sustained release governed by diffusion mechanism. A more flat curve occurred when the diameter of PU shell increased. In this case, the PU shell served as a barrier restricted DIP release from core drug reservoir. In vitro platelet adhesion test demonstrated that the DIP had maintained its antiplatelet effect after coaxial electrospinning process and could present distinguished antiplatelet activity after 7th and 30th days. Finally, DIP loaded core-shell nanofiber mats with good hemocompatibility, were conveniently fabricated by coaxial electrospinning, which has great potential in the field of tissue engineering vascular graft.

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Section: Coaxial Electrospinningmentioning

confidence: 99%

Preparation of Dipyridamole/Polyurethane Core–Shell Nanofibers by Coaxial Electrospinning for Controlled-Release Antiplatelet Application

Qin¹,

Liu²,

Zhao³

et al. 2016

j nanosci nanotechnol

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“…To address these challenges, finding alternatives to autologous vessels have attracted so much attention and the efforts have focused on developing vascular substitutes . Synthetic polymers such as polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), polyurethane (PU), poly( l ‐lactic acid) (PLLA), poly(lactic‐co‐glycolic acid) (PLGA), and polycaprolactone (PCL) have been utilized to introduce cardiovascular devices such as vascular graft, artificial heart, and heart valves for the matter of their biocompatibility and controlled mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Electrospun polyethylene terephthalate (PET) nanofibrous conduit for biomedical application

Jafari

Salekdeh

Solouk

et al. 2019

Polymers for Advanced Techs

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Nanostructured biomaterials have great potential in the field of biomedical engineering. Efforts for treatment of cardiovascular diseases focused on introducing vascular substitutes that are nonthrombogenic and have long-term patency, but still there is not any perfect replacement for clinical use. In this study, nanostructure tubes of a commonly known biocompatible polymer, polyethylene terephthalate (PET), were prepared via electrospinning process using small diameter mandrel as a collector with two different speeds. The nanofibers (NFs) morphologies' physical and mechanical properties were investigated according to scanning electron microscope (SEM), water contact angle (WCA), porosity measurement, differential scanning calorimetry (DSC), and tensile test. Finer NFs, more percentage of crystallinity, and superior mechanical properties were observed for samples prepared by higher speed mandrel. Since both samples stimulated platelet adhesion and activation, further surface modification with sodium nitrate as nitric oxide (NO) donor was done using two different approaches: dip-coating and electrospraying. The modified NFs were evaluated via SEM, WCA, tensile test, platelets, and cell adhesion. The results showed more hydrophilicity, reduction in platelet adhesion, and improved blood compatibility for eNO-HS (electrosprayed NO for higher collector speed) compared with other samples implying the promising potential of this fabrication and modification technique for improving PET-based cardiovascular substitutes.

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“…The role of properties such as diameter size, orientation and interconnec-tivity of fibres in promoting attachment and proliferation of various skin cells are well studied [5,20,21]. In addition, it also influences the blood compatibility and antimicrobial activity of the material by limiting the interaction with associated cell types [22,23]. Hence, the optimum features of the electrospun scaffold not only determine its ability to mimic native extracellular matrix (ECM), but also its biocompatibility.…”

Section: Semmentioning

confidence: 99%

Advanced nanofibrous textile-based dressing material for treating chronic wounds

et al. 2018

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In the present work, an electrospun nanofibrous textile composed of polyurethane (PU), sodium bicarbonate (NaHCO 3) and pantothenic acid (PA) is developed for treating chronic wounds. Wounds are a common health problem and in particular, the chronic wounds such as vascular ulcers, diabetic ulcers and pressure ulcers cause a large number of morbidity and mortality. The main problems of the chronic wounds are prolonged inflammation phase and presence of acidic environment. These events deactivate the operation of growth factors and also the progression of natural healing mechanism. Hence, various types of advanced textile-based dressings are developed to address the clinical complications associated with chronic wound management. The prepared electrospun scaffolds were characterized to study their physicochemical and haemocompatible properties. The scanning electron microscopy micrographs depicted continuous, smooth-interconnected nanofibrous morphology of PU-NaHCO 3-PA scaffolds. The Fourier transform infrared spectroscopy spectra indicated the addition of NaHCO 3 and PA-based hydrophilic chemical groups, which significantly enhanced the wettability of the composites. Further, the PU-NaHCO 3-PA composite membrane inferred to have a highly porous structure with the mean porosity of 79.4 ± 4.8%, which may provide a conducive environment for adherence and proliferation of skin cells. The composite scaffold also offers a highly haemocompatible surface by delaying coagulation of blood through contact activation pathways and by limiting red blood cells damage. Therefore, the excellent physicochemical properties, blood compatibility and the delivery of PA are anticipated to speed up the impaired healing process of chronic wounds.

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The in vivo blood compatibility of bio-inspired small diameter vascular graft: effect of submicron longitudinally aligned topography

Cited by 33 publications

References 43 publications

Preparation of Dipyridamole/Polyurethane Core–Shell Nanofibers by Coaxial Electrospinning for Controlled-Release Antiplatelet Application

Preparation of Dipyridamole/Polyurethane Core–Shell Nanofibers by Coaxial Electrospinning for Controlled-Release Antiplatelet Application

Electrospun polyethylene terephthalate (PET) nanofibrous conduit for biomedical application

Advanced nanofibrous textile-based dressing material for treating chronic wounds

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