The Incidence and Mortality of Colorectal Cancer and Its Relationship
                        With the Human Development Index in Asia

Ghoncheh, Mahshid; Mohammadian, Maryam; Mohammadian-Hafshejani, Abdollah; Salehiniya, Hamid

doi:10.1016/j.aogh.2016.10.004

Cited by 44 publications

(35 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study herein showed that the incidence of CRC in men was higher than that of women; this is consistent with the results of others [20]. The mean age of patients with CRC in the study area was ~55 years [8], and more serious pattern with rising risk of CRC-related mortality was observed in northwestern neighboring countries (like Turkey, Armenia…) [26]. The results of previous studies in Iran and other countries indicate that CRC in men and women are different in each country and region [8,26,27].…”

Section: Discussionsupporting

confidence: 92%

“…The mean age of patients with CRC in the study area was ~55 years [8], and more serious pattern with rising risk of CRC-related mortality was observed in northwestern neighboring countries (like Turkey, Armenia…) [26]. The results of previous studies in Iran and other countries indicate that CRC in men and women are different in each country and region [8,26,27]. To our knowledge, it seems likely that deficient in some key trace elements [8] and the microbial flora [28] of the colon at older than 50 could be a significant attributable factor for the development of CRC.…”

Section: Discussionmentioning

confidence: 89%

“…Upper panel, the study area (Northeastern Iran with comparative countrywide information related to colorectal cancer (CRC) rate per 100000 in male (♂) and female (♀), referred to hospitals in 2014. [other than the study area are referred to(26)]. The https://en.wikipedia.org/wiki/Module:Location_map/data/Iran/doc-linked map was created/modified using Arc.GIS software (version 10.2.0.3348) and 2013© Microsoft Windows, Paint (version 6.3).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Clinicodemographical assessment of colorectal cancer with emphasis on B3GALNT2, MUC1, P53 and Ki67-related risk of metastasis

Ranjbary

Mehrzad

Abdollahi

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: The incidence of colorectal cancer (CRC) is rising, worldwide, and is attributed to genetics and epigenetic factors. We aimed to evaluate the key clinicodemographical/epidemiological-and molecular impacts on metastatic CRC in CRC patients from a highly populated area in northeastern Iran. Retrospective clinical materials-based cohort design and patients were analyzed with respect to age, sex, colorectum anatomy, metastasis, mortality as well as to expression of molecular markers B3GALNT2, mucin I ( MUC1), P53 and Ki67. Methods: Patients, 6260 registered CRC with 3829 underwent surgery, from three medical university hospitals in the study area, during 2006-2016, were analyzed for the clinicodemographic aspects of age, sex, stage of CRC, history of smoking, familial/occupational status and post-surgery survival period as well as mRNA/protein expression of B3GALNT2, MUC1, P53 and Ki67. Factors were set to estimate mortality and risk of metastatic CRC. Results: ~61%, ~33% and ~6% of adenocarcinomatous CRC were located in colon, rectum and rectosigmoid, respectively, of which younger-and older than 50 was mainly in transvers colon-and colorectum, respectively. Post-surgery survival period of metastatic CRC patients was remarkably longer in patients aged > 50 than those < 50 years old, and worse in females than males. B3GALNT2 high , MUC1 high , P53 low and Ki67 high mRNA/protein expression in metastatic stage III CRC were highly associated with increased metastasis and mortality. B3GALNT2 high , MUC1 high , P53 low and Ki67 high mRNA/protein expression correlated with increased risk of a progressed CRC state and mortality. The risk to develop metastatic CRC was higher in males, younger, urban residing-and employed individuals, indicative of a plausible non-genetics/epigenetics contribution to CRC. Conclusions: The role of possible diagnostic biomarkers, B3GALNT2, MUC1 and Ki67, but not P53, in the etiology/early detection of metastatic CRC is promising. Epigenetic contribution to metastatic CRC risk is predominant.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 89%

mentioning

confidence: 99%

See 1 more Smart Citation

Clinicodemographical assessment of colorectal cancer with emphasis on B3GALNT2, MUC1, P53 and Ki67-related risk of metastasis

Ranjbary

Mehrzad

Abdollahi

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Colorectal cancer (CRC) accounts for 9% of all cancers globally,1 2 making it the second most common cancer in women and the third most common in men 1. Adenocarcinoma that arises from the colonic and rectal epithelium accounts for 90% of CRC cases 3.…”

Section: Introductionmentioning

confidence: 99%

Cancer stem cells in colorectal cancer: a review

et al. 2017

View full text Add to dashboard Cite

Colorectal cancer (CRC) is the second most common cancer in women and the third most common in men. Adenocarcinoma accounts for 90% of CRC cases. There has been accumulating evidence in support of the cancer stem cell (CSC) concept of cancer which proposes that CSCs are central in the initiation of cancer. CSCs have been the focus of study in a range of cancers, including CRC. This has led to the identification and understanding of genes involved in the induction and maintenance of pluripotency of stem cells, and markers for CSCs, including those investigated specifically in CRC. Knowledge of the expression pattern of CSCs in CRC has been increasing in recent years, revealing a heterogeneous population of cells within CRC ranging from pluripotent to differentiated cells, with overlapping and sometimes unique combinations of markers. This review summarises current literature on the understanding of CSCs in CRC, including evidence of the presence of CSC subpopulations, and the stem cell markers currently used to identify and localise these CSC subpopulations. Future research into this field may lead to improved methods for early detection of CRC, novel therapy and monitoring of treatment for CRC and other cancer types.

show abstract

“…The therapeutic approaches for colorectal cancer are surgery, neoadjuvant radiotherapy (for rectal cancer), and adjuvant chemotherapy (for stage III/IV and high-risk stage II colon cancer) (7). However, the 5-year survival rate for colorectal cancer patients ranges from more than 90% in stage I patients to slightly higher than 10% in stage IV patients (8). Thus, it is pivotal to better understand the biological and immunological mechanism for colorectal cancer progression and clinical relevant insights for management of the disease.…”

Section: Introductionmentioning

confidence: 99%

Interleukin-24 Regulates T Cell Activity in Patients With Colorectal Adenocarcinoma

Zhang

Liu²,

2019

Front. Oncol.

View full text Add to dashboard Cite

Interleukin (IL)-24 plays a potential anti-tumor activity in colorectal cancer in a dose-dependent manner. However, the immunoregulatory role of IL-24 to peripheral and tumor-infiltrating T cell function in colorectal cancer was not fully elucidated. In this study, twenty-nine colorectal adenocarcinoma patients and fifteen healthy individuals were enrolled. IL-24 expression and IL-24 receptor (IL-20R1, IL-20R2, and IL-22R1) mRNA relative level was measured by ELISA and real-time PCR, respectively. CD4 + and CD8 + T cells were purified from peripheral bloods and cancer specimens, and were stimulated with low (10 ng/ml) and high (100 ng/ml) concentration of recombinant IL-24. CD4 + T cells activity was assessed by measurement of Th cell percentage, transcriptional factors, and cytokine production. CD8 + T cells activity was evaluated by investigation of cytotoxic molecules, target cell death, and interferon-γ (IFN-γ) secretion. IL-24 was decreasingly expressed in both peripheral bloods and cancer tissues in colorectal adenocarcinoma patients. However, IL-20R1 and IL-20R2 was comparable between healthy controls and colorectal adenocarcinoma patients. Low concentration of IL-24 suppressed CD4 + T cell proliferation. In contrast, high concentration of IL-24 not only promoted CD4 + T cell proliferation, but also enhanced CD4 + T cell activity, which mainly presented as up-regulation of Th1/Th17 frequency, T-bet/RORγt mRNA, and IFN-γ/IL-17 production but down-regulation of Treg percentage, FoxP3 mRNA, and IL-10/IL-35 secretion. Moreover, high concentration of IL-24 also increased perforin and granzyme B expression in CD8 + T cells, and elevated cytolytic and non-cytolytic activity of CD8 + T cells, which presented as induction of target cell death and elevation of IFN-γ expression. However, low concentration of IL-24 did not affect bioactivity of CD8 + T cells. The current data indicated that IL-24 might regulate T cell function in a dose-dependent manner. High-concentration of IL-24 might promote anti-tumor immune responses in development novel therapeutic approaches to colorectal adenocarcinoma.

show abstract

The Incidence and Mortality of Colorectal Cancer and Its Relationship With the Human Development Index in Asia

Abstract: Cancer incidence and mortality are higher in countries with more development. A positive and statistically significant correlation was found between standardized incidence and mortality rate of colorectal cancer and the Human Development Index and its components.

Cited by 44 publications

References 25 publications

Clinicodemographical assessment of colorectal cancer with emphasis on B3GALNT2, MUC1, P53 and Ki67-related risk of metastasis

Clinicodemographical assessment of colorectal cancer with emphasis on B3GALNT2, MUC1, P53 and Ki67-related risk of metastasis

Cancer stem cells in colorectal cancer: a review

Interleukin-24 Regulates T Cell Activity in Patients With Colorectal Adenocarcinoma

Contact Info

Product

Resources

About