The incidence and risk factors of gastrointestinal complications after hepatectomy: a retrospective observational study of 1329 consecutive patients in a single center

Li, Bao-Chuan; Xia, Zhi-Qiu; Li, Cai; Liu, Weifeng; Wen, Sijian; Liu, Ke-Xuan

doi:10.1016/j.jss.2014.06.015

Cited by 7 publications

(4 citation statements)

References 26 publications

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“…Over the past few years, the hepatobiliary surgery have resulted in good perioperative results in several centres, with operative mortality rates lower than 5% [6, 7]. As a result, hepatectomies are performed with greater frequency with the feasibility of segment-oriented resections and indications for liver resection have broadened in patients with a normal liver [8]. When major hepatic resection is required, especially for patients with chronic liver disease, the hepatic resection is still challenging.…”

Section: Introductionmentioning

confidence: 99%

Prediction of perioperative outcome after hepatic resection for pediatric patients

et al. 2019

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BackgroundHepatic resection is associated with significant risk of morbidity and mortality. Optimising the surgical techniques and perioperative management may improve in operative morbidity and mortality. However, perioperative variables involved in the improvement for postoperative outcomes in pediatric hepatectomy have not been defined.MethodsWe retrospectively reviewed 156 consecutive pediatric patients who underwent hepatectomy at our center (an academic tertiary care hospital) between 2006 and 2016. Baseline demographic variables, intraoperative variables, complications, and hospital stay were explored. The patients were further investigated using univariate and multivariate analysis for the factors involved in the postoperative outcomes.ResultsOf the conditions requiring resections, malignant and benign liver diseases accounted for 47.4% (74/156) and 52.6% (82/156), respectively. The overall hospital mortality was 1.9% (3/156) and the overall postoperative complication rate was 44.2% (69/156). Anatomical resections were performed in 128 patients (82.1%), including 14(9.0%) extended hepatectomies. Eighty percent of patients had three or more segments resected. The median operative time was 167.7 (65–600) minutes and median estimated blood loss was 320.1(10–1600) mL. On multivariate analysis, the estimated blood loss (EBL) (mL) (OR, 2.19; 95CI, 1.18–3.13; p = 0.016), extent of hepatectomy (OR, 1.81; 95CI, 1.06–2.69; p = 0.001) and pringle maneuver (OR, 1.38; 95CI, 1.02–1.88; p = 0.038) were the independent predictors of postoperative complications.ConclusionsExtent of hepatectomy and estimated blood loss are largely responsible for the perioperative complications. With the surgical devices and management amelioration, like pringle maneuver, the treatment planning may be optimize in pediatric liver resection.

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Section: Introductionmentioning

confidence: 99%

Prediction of perioperative outcome after hepatic resection for pediatric patients

et al. 2019

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“…[3][4][5][6][7][8] However, with improved understanding of the mechanism, a series of nerve reflexes caused by skin incision, inflammatory and immune cascading reactions caused by peritoneum and intestinal tube operation, and the activation of μ receptors in the intestinal muscular layer by opioids during the perioperative period have been identified as important underlying mechanisms. In addition to operation, anaesthetics can also influence postoperative gastrointestinal function, 9 such as atropine, inhaled anaesthetics (enflurane or halothane) and opioids, all of which can inhibit intestinal peristalsis, 10 especially opioids that have significant effect among these. 11 Furthermore, studies have shown that the suppressive effect manifests as dose dependence.…”

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confidence: 99%

Effect of multimodal preemptive analgesia on postoperative gastrointestinal function and clinical outcome in patients undergoing laparoscopic colorectal surgery

Liu

Wang

Kang

et al. 2021

Int J Clinical Practice

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Objective This study aimed to investigate the effects of multimodal preemptive analgesia on postoperative gastrointestinal function and clinical outcomes in patients undergoing laparoscopic colorectal surgery. Methods This prospective study included a total of 108 patients undergoing elective laparoscopic colorectal surgery from June 2019 to June 2020. The patients were divided into the control group and the study group according to the random number table method. Patients in the study group were given flurbiprofen axetil and oxycodone before skin incision combined with bilateral transverse abdominis plane block (TAPB) before anaesthesia induction. In the control group, patients were given sufentanil and flurbiprofen axetil combined with bilateral TAPB in postanaesthesia care unit (PACU). The incidence of postoperative gastrointestinal dysfunction (POGD), I‐FEED score, inflammatory factor levels, rehabilitation indicators, postoperative pain assessment and other organ complications were observed and compared between the two groups. Results The incidence of POGD in the study group was lower compared to the control group, and the difference was statistically significant (P < .05). The study group had lower total and mean scores of I‐FEED at 24, 48, 72 and 96 hours after surgery; however, the differences were not statistically significant (P > .05). On the first and third day after operation, Lipopolysaccharide (LPS), C‐reactive protein (CRP), Tumour necrosis factor (TNF‐α) and Interleukins6 (IL‐6) levels of the study group decreased significantly (P < .05). The reduction in inflammation factor levels from 1d to 3d was significantly greater than that of the control group (P < .05). Conclusion The strategy of multimodal preemptive analgesia can effectively prevent the onset of POGD and may accelerate rehabilitation. In short, multimodal preemptive analgesia provides a novel prevention strategy for patients undergoing laparoscopic colorectal surgery.

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“…Although Pringle maneuver is a commonly used technique to control bleeding, ischemia-reperfusion injury remains a major complication [12]. Furthermore, blockage of the mesenteric venous drainage could elevate the intestinal microvascular network pressure, which could induce bacterial translocation and result in gastrointestinal complications [28]. Moreover, Pringle maneuver has been associated with increased postoperative ascites and pleural effusion [29].…”

Section: Discussionmentioning

confidence: 99%

Beneficial impact of microwave ablation-assisted laparoscopic hepatectomy in cirrhotic hepatocellular carcinoma patients: a propensity score matching analysis

Jin

Liu

Dai

et al. 2019

International Journal of Hyperthermia

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Purpose: In this study, we evaluated the efficacy of microwave ablation-assisted laparoscopic hepatectomy (MLH) for the management of hepatocellular carcinoma (HCC) in cirrhotic patients. Methods: Data from HCC patients with liver cirrhosis who underwent laparoscopic hepatectomy (LH) or MLH in Shengjing Hospital (Shenyang, China) were retrospectively analyzed from January 2013 to June 2017. The demographic characteristics, clinical features, intraoperative parameters and surgical outcomes were analyzed and compared. Propensity scores matching (PSM) analysis was used to minimize bias. Results: A total of 54 patients were enrolled in the MLH group and 39 patients in the LH group. Following 1:1 matching by PSM analysis, 26 patients were selected from each group. Compared to the LH group, patients in the MLH group had significantly decreased intraoperative bleeding (48.0 vs. 203.9 ml, p < .0001) and reduced demand for hepatic inflow occlusion (0 vs. 6, p ¼ .009). No significant difference was observed in average operation time (155.7 vs. 148.5 min) and postoperative hospitalization time (8.3 vs. 9.3 d) between the MLH and LH groups. Similarly, the 1-year and 3-year recurrencefree survival (RFS) rates as well as the 1-year and 3-year overall survival (OS) rates of the MLH and LH groups were not significantly different (83.1 vs. 82.4% and 64.6 vs. 36.6% as well as 100 vs. 95.8% and 93.8 vs. 59.1%, respectively: p > .05). Conclusions: MLH significantly decreased intraoperative bleeding and reduced the need for hepatic occlusion without compromising the surgical outcome. Therefore, microwave ablation could be a valuable tool for LH in HCC patients with cirrhosis.

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The incidence and risk factors of gastrointestinal complications after hepatectomy: a retrospective observational study of 1329 consecutive patients in a single center

Cited by 7 publications

References 26 publications

Prediction of perioperative outcome after hepatic resection for pediatric patients

Prediction of perioperative outcome after hepatic resection for pediatric patients

Effect of multimodal preemptive analgesia on postoperative gastrointestinal function and clinical outcome in patients undergoing laparoscopic colorectal surgery

Beneficial impact of microwave ablation-assisted laparoscopic hepatectomy in cirrhotic hepatocellular carcinoma patients: a propensity score matching analysis

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