The Incidence and Survival Rate of Population-Based Pancreatic Cancer Patients: Shanghai Cancer Registry 2004–2009

Abstract

BackgroundPancreatic cancer is a devastating disease with dismal prognosis. Large population-based evidence on its survival rate and influence factors is lacking in China.ObjectiveThis study aimed to depict the demographic factors, tumor characteristics, incidence rate and survival rate of pancreatic cancer cases in urban China.MethodsThe demographic factors, tumor characteristics were collected for all the pancreatic cancer cases identified during 2004 to 2009 from the Shanghai Cancer Registry. The survival time was ascertained through linkage of the Shanghai Cancer Registry and the Shanghai Vital Statistics Registry. The deadline of death certificates was the end of December 2012. Kaplan-Meier method and Cox proportional-hazards regression model were used to explore the survival rate and influence factors.Results11,672 new pancreatic cancer cases were identified among Shanghai residency during 2004 to 2009. The crude incidence rate of pancreatic cancer was increasing from 12.80/100,000 in 2004 to 15.66/100,000 in 2009, while the standardized incidence rate was about 6.70/100,000 and didn't change a lot. The overall 5-year survival rate was 4.1% and the median survival time was 3.9 (95% Confidence Interval (CI) 3.8–4.0) months. Subjects had received surgical resection had improved survival (HR = 0.742, 95% CI: 0.634–0.868) than its counterparts. In adjusted multivariable Cox proportional-hazard models, factors associated with poor survival included older age at diagnosis (age > = 70 years: hazard ratio (HR) = 1.827, 95% CI: 1.614–2.067), male sex (HR = 1.155, 95% CI: 1.041–1.281), distant disease at diagnosis (HR = 1.257, 95% CI: 1.061–1.488), positive lymph node (HR = 1.236, 95% CI: 1.085–1.408), tumor stage (Stage IV HR = 2.817, 95% CI: 2.029–3.909).ConclusionThe age-adjusted incidence rate was stable and overall survival rate was low among pancreatic cancer patients of Shanghai residency. Early detection and improved treatment strategies are needed to improve prognosis for this deadly disease.

Clinical Outcome of Exocrine Pancreatic Adenocarcinoma: A Single Center Experience

“…Mishra et al found that younger age and female gender were associated with better prognosis 23 . In contrast to that, Tas et al, Worni et al, Gong et al and Luo et al found that shorter survival was associated with older age at diagnosis and male sex 14,16,24,25 .…”

Cancer survival in Qidong between 1972 and 2011: A population-based analysis

“…Table IV shows the 5-year observed and relative survival by age group (15-34, 35-44, 45-54, 55-64, 65-74, and 75+) for all the major cancer sites. Relatively higher survival rates were observed in younger patients (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44) compared with older patients (65-74, 75+), particularly for sites including the stomach, lung, pancreas, B and CNS, blood (NHL) and cervix. Cancer of the oesophagus, female breast and bladder had higher survival in middle-aged groups (45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)…”

“…There have been few studies referring to population-based cancer survival in mainland China. Previous studies have reported on population-based cancer survival in Shanghai (38) and Zhejiang (39); however, these studies primarily focused on a certain or some cancer sites over a short time period. In Taiwan, the survival rates for epithelial ovarian cancer and uterine cancer were reported based upon data from a population-based registry (40,41).…”

Patterns and Trends with Cancer Incidence and Mortality Rates Reported by the China National Cancer Registry

“…This paper attempts to explore part of the patterns and trends hidden behind these published CCRARs. Although a few researchers have performed some secondary analysis using Peng-Lai Chen et al data from certain single CCRAR (Luo et al, 2013), there lack published studies that tried to pool and analyze data from multiple CCRARs.…”