The incidence of allergic disorders and cancer.

Mackay, W D

doi:10.1038/bjc.1966.52

Cited by 85 publications

(32 citation statements)

References 10 publications

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“…For this reason we wished to include questions additional to those concerning colds in the questionnaire. History of allergy seemed a good choice for inclusion because of the contradictory results obtained from earlier studies (Logan & Saker, 1955;Fisherman, 1960;Mackay, 1966;McKee et al, 1967;Ure, 1969;Shapiro et al, 1971;Gabriel et al, 1972;Meers, 1973;Alderson, 1974;Polednak, 1975;Allegra et al, 1976;Robinette & Fraumeni, 1978 analyses were repeated for the subset of cases and controls interviewed within 3 months of first diagnosis (81 cases and 145 controls); the results were similar to those reported in Table III. The relative risk of 6 found by Remy et al (1983) contrasts with our relative risk of 1.4.…”

supporting

confidence: 58%

“…One other study may be methodologically sound (Allegra et al, 1976) and suggests a large negative effect although based on very small numbers; 1/74 cases and 13/86 controls had a history of allergy. The other studies, of which 5 find a statistically significant negative association (Fisherman, 1960;Mackay, 1966;Ure, 1969, Gabriel et al, 1972Meers, 1973) and one a significant positive association between history of allergy and cancer (Logan & Saker, 1955), are uninterpretable. Three cohort studies have looked specifically at asthma.…”

mentioning

confidence: 97%

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The common cold, allergy, and cancer

Chilvers¹,

Johnson²,

Leach³

et al. 1986

Br J Cancer

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During 1982, one of us (EV) observed in the course of health visiting that patients with cancer had common colds less frequently than patients with other diseases. A small case-control study of the relationship between history of common colds and cancer was carried out by this same observer and the results confirmed her previous observation. More recently Remy et al. (1983) carried out a similar study; from data given in their Figure 1

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supporting

confidence: 58%

mentioning

confidence: 97%

The common cold, allergy, and cancer

Chilvers¹,

Johnson²,

Leach³

et al. 1986

Br J Cancer

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“…Early studies purported to show that the incidence of atopy was decreased in cancer patients (Fisherman, 1960;Mackay, 1966) but subsequent large controlled studies were unable to verify the earlier claims (McKee et al, 1967;Shapiro et al, 1971) and the consensus of opinion now is that the presence of atopy does not protect against oncogenesis (for review, see Rosenbaum & Dwyer, 1977). However none of these studies examined how atopic cancer patients fared compared to their non-atopic counterparts.…”

mentioning

confidence: 99%

Atopy—A favourable prognostic factor for survival in Hodgkin's disease

Amlot¹,

Slaney²,

Brown³

1983

Br J Cancer

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“…When IgE was inhibited with this anti-IgE antibody, 1 in 200 asthmatic patients developed breast, skin, prostate or parotid gland malignancies during the median observation period of 1 year, whereas in the control group, the incidence was 1:500. 6 The picture becomes clearer when one focuses on IgE specific for cancer cell antigens. There are early observations of ''natural'' IgE-mediated mechanisms in cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Active Induction of Tumor-Specific IgE Antibodies by Oral Mimotope Vaccination

Riemer¹,

Untersmayr²,

Knittelfelder³

et al. 2007

Cancer Research

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A role of IgE antibodies in cancer surveillance has been implicated for a long time. Studies dealing with IgE antibodies directly targeted to tumor antigens have shown marked anticancer effects mediated by this antibody class. Thus, the basic function of IgE antibodies may be to control tumor growth. Thus far, cancer-specific IgE has only been applied passively. Consequently, the aim of this study was to establish an active vaccination protocol to induce tumor antigenspecific IgE antibodies, and to evaluate functional properties. We previously generated epitope mimics, so-called mimotopes, for the epitope recognized by the anti-HER-2 antibody trastuzumab. Upon i.p. immunizations, IgG antibodies with trastuzumab-like properties could be elicited. In the present study, we immunized BALB/c mice via the oral route with these trastuzumab mimotopes, under simultaneous neutralization and suppression of gastric acid. As shown in preceding experiments, this feeding regimen effectively induces Th2 immune responses. Oral immunizations with trastuzumab mimotopes under hypoacidic conditions indeed resulted in the formation of IgE antibodies towards the HER-2 antigen. Moreover, anti-HER-2 IgE-sensitized effector cells mediated SK-BR-3 target cell lysis in an antibody-dependent cytotoxicity assay. We conclude that directed and epitope-specific induction of IgE against tumor antigens is feasible with an oral mimotope vaccination regimen, and that these antibodies mediate anticancer effects. [Cancer Res 2007;67(7):3406-11]

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The incidence of allergic disorders and cancer.

Cited by 85 publications

References 10 publications

The common cold, allergy, and cancer

The common cold, allergy, and cancer

Atopy—A favourable prognostic factor for survival in Hodgkin's disease

Active Induction of Tumor-Specific IgE Antibodies by Oral Mimotope Vaccination

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