The incidence of bacteraemia after argon plasma coagulation in patients with chronic radiation proctocolitis

Lenz, Luciano; Tafarel, Jean Rodrigo; Correia, Leonardo; Bonilha, Danielle Queiroz; Monaghan, Mark; Santos, Marcus; Gomes, Gustavo F.; Martins, Fernanda P.; Nakao, Frank Shigueo; Líbera, Ermelindo Della; Rohr, Rachel; Ferrari, A

doi:10.1111/j.1463-1318.2010.02279.x

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…No additional studies were found by hand‐screening of the included articles’ references. Finally, 111 met the criteria . Additional information was kindly provided by the corresponding author of one study .…”

Section: Resultsmentioning

confidence: 99%

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Rhodotorula species infections in humans: A systematic review

Ιωάννου

Vamvoukaki

Samonis

2018

Mycoses

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| INTRODUC TI ONRhodotorula belongs to the phylum Basidiomycota and forms spherical-to-ellipsoidal budding yeast as well as rudimentary hyphae and small capsules. 1 It is widely distributed in the environment and is also found in the normal flora of the human gastrointestinal, respiratory and genital system as well as in the moist areas of the skin. 2 Even though it had been considered nonpathogenic, in the last decades there is growing evidence that it can be important human pathogen, especially in immunocompromised hosts, causing a variety of different infections, such as fungaemia, meningitis, peritoneal dialysis-associated peritonitis and keratitis. 3,4 The purpose of this study was to systemically review all published cases of Rhodotorula infections in the literature and describe the epidemiology, microbiology, treatment and outcomes of these infections in humans. SummaryBackground: Fungal infections by Rhodotorula species are increasingly reported in the literature and consist of bloodstream infections, especially in patients with central venous catheters (CVC), as well as central nervous system (CNS), ocular and other less frequent infections. Objectives: The aim of this systematic review was to record and evaluate all available evidence regarding infections by Rhodotorula species. Methods: Systematic review of PubMed (through 9 August 2017) for studies providing epidemiological, clinical, microbiological, as well as treatment data and outcomes of Rhodotorula species infections.Results: A total of 111 studies, containing data of 248 patients, were eventually included in the analysis. The most common Rhodotorula infections were those of bloodstream, CNS and ocular infections, as well as peritoneal dialysis-associated peritonitis.Epidemiology of each type of infection was different, with the bloodstream ones being more common in patients with malignancy and CVCs, while those of the CNS were more common in patients with AIDS. Mortality was variable being higher in CNS infections. Amphotericin B remains the most common agent used for treatment, irrespectively of the infection site. Conclusions: This systematic review thoroughly describes fungal infections byRhodotorula species and provides information on their epidemiology, clinical picture, microbiology, treatment and outcomes. K E Y W O R D S fungaemia, fungal infection, keratitis, meningitis, peritonitis, Rhodotorula | 91 IOANNOU et Al. with the following text-word: Rhodot*[tw]. Day of last search was 9 August 2017. | Study selectionStudies were included in analysis if they met the following criteria: (a) published in English; and (b) reporting data on patients' clinical characteristics, microbiology, treatment and outcomes. From the analysis were excluded studies with the following criteria: (a) secondary research papers (eg, reviews), editorials and papers not reporting results on primary research; (b) studies not in humans; (c) studies on colonisation but not infection by Rhodotorula; and (d) studies not in English. Two investigators (PI and RV) using Ab...

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Section: Resultsmentioning

confidence: 99%

“…Among the 111 Rhodotorula infections studies, 54 (48.6%) reported fungaemias, accounting for 153 patients out of 248 (61.7%) in total . Among patients with fungaemia, 62.8% were male (76 out of 121 cases w.a.d.)…”

Section: Resultsmentioning

confidence: 99%

Rhodotorula species infections in humans: A systematic review

Ιωάννου

Vamvoukaki

Samonis

2018

Mycoses

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“…[39][40][41][42][43] Some of the older techniques and those for which limited data exist will not be discussed further. Instead, we will address techniques that appear to be more widely used, such as APC.…”

Section: Endoscopic Interventionsmentioning

confidence: 97%

Management of Radiation Proctitis

Mendenhall

McKibben²,

Hoppe³

et al. 2014

American Journal of Clinical Oncology

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The optimal management of radiation proctitis is ill defined. A variety of alternatives are available and include topical agents (ie, sucralfate enemas, formalin), oral agents (ie, pentoxyfylline, vitamin A), hyperbaric oxygen, and endoscopic interventions (ie, argon plasma coagulation). It is prudent to manage patients conservatively and to intervene only when necessary with the option least likely to exacerbate the proctitis. Rectal biopsies should be avoided as they may precipitate a complication. More aggressive measures, such as argon laser coagulation, should be employed only when more conservative approaches fail.

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“…79 Another possible complication after APC is bacteremia. 80 In 2011, Lenz et al 80 found a rate of bacteremia of 7% in a small sample of patients undergoing APC.…”

Section: Argon Plasma Coagulationmentioning

confidence: 99%

Therapeutics in Radiation-induced Proctopathy: A Systematic Review

Omer

Araújo

Cruz³

et al. 2022

Journal of Coloproctology

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Malignant neoplasms are increasingly prevalent in the daily clinical practice. Up to 61% of patients with pelvic malignancies undergo pelvic radiotherapy in different doses, which may cause intestinal damage, and the rectum is the segment most frequently affected due to its fixed position in the pelvis. Currently, there are several strategies to minimize the effects of radiation on the tissues surrounding the neoplastic site; despite those strategies, radiotherapy can still result in serious damage to organs and structures, and these injuries accompany patients throughout their lives. One of the most common damages resulting from pelvic radiotherapy is acute proctitis.The diagnosis is confirmed by visualizing the rectal mucosa through rigid or flexible rectosigmoidoscopy and colonoscopy. The objective of the present study was to review the forms of radiation-induced proctopathytherapy, and to evaluate the results of each method to propose a standardization for the treatment of this pathology. Despite the prevalence of radiation-induced proctopathy, there is no definitive standardized treatment strategy so far. The first approach can be tried with local agents, such as mesalazine and formalin. For refractory cases, control can usually be achieved with argon plasma coagulation, hyperbaric oxygen, and radiofrequency ablation therapies. Regarding the study of radiation-induced proctopathy, there is a lack of robust studies with large samples and standardized therapies to be compared. There is a lack of double-blinded, randomized controlled studies to determine a definitive standard treatment algorithm.

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The incidence of bacteraemia after argon plasma coagulation in patients with chronic radiation proctocolitis

Abstract: APC is a low-risk procedure regarding bacteraemia and does not warrant prophylactic antibiotic administration.

Cited by 5 publications

References 15 publications

Rhodotorula species infections in humans: A systematic review

Rhodotorula species infections in humans: A systematic review

Management of Radiation Proctitis

Therapeutics in Radiation-induced Proctopathy: A Systematic Review

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