The incidence of cervical intraepithelial neoplasia in a population of pregnant women with an abnormal cytology

Pruski, Dominik; Malkowska-Walczak, Blanka; Paluszkiewicz, Aleksandra; Kędzia, Witold

doi:10.5603/gp.a2017.0004

Cited by 2 publications

(2 citation statements)

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“…A gynaecologist has to frequently consider the validity of a comprehensive surgical procedure, that is a cervical biopsy, and the risk of complications in normally developing pregnancy in patients with questionable cytology results, according to The Bethesda System. In fact, ASCUS and LSIL cytological diagnosis constitutes the most frequent abnormal result in pregnant patients [21].…”

Section: Discussionmentioning

confidence: 99%

Sensitivity and specificity of hr hPV E6/E7 mrna test in detecting cervical squamous intraepithelial lesion and cervical cancer

Pruski

Przybylski

Lewek³

et al. 2019

Ginekol Pol

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Objectives: The paper assess the relevance of HR HPV E6/E7 mRNA test in women with abnormal Pap results. Material and methods: Between 2013-2014, 125 women were subjects to the enhanced diagnostics due to abnormal Pap results. According to The Bethesda system, if ASC-US, AGC, LSIL, ASC-H, HSIL or cancer cells were present, the result was abnormal. The patients underwent the enhanced diagnostics which included the following procedures: Pap smear collection for molecular assessment of HR HPV E6/E7 mRNA test, the colposcopic examination and biopsy of clinically suspicious areas. Results: High-grade squamous intraepithelial lesions constituted the most frequent cervical pathology in women with abnormal Pap test results, as well as with the positive results of HR HPV E6/E7 mRNA test. Test sensitivity in patients with the histopathological diagnosis of high-grade squamous intraepithelial lesion was estimated at 86.1%. Conclusions: HR HPV E6/E7 mRNA test identifying neoplastic lesions and cervical cancer is characterised by a high relevance which is reflected by means of sensitivity and specificity. In fact, test sensitivity and specificity increased with the age in the group of patients up to 50 years old.

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Section: Discussionmentioning

confidence: 99%

Sensitivity and specificity of hr hPV E6/E7 mrna test in detecting cervical squamous intraepithelial lesion and cervical cancer

Pruski

Przybylski

Lewek³

et al. 2019

Ginekol Pol

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“…So far, some literature data have focused on the disappearance of early lesions [34] in the HPV-positive population; still, no PubMed publications mention the disappearance of HPV infection after the use of the nine-valent vaccine.…”

Section: Introductionmentioning

confidence: 99%

Effect of HPV Vaccination on Virus Disappearance in Cervical Samples of a Cohort of HPV-Positive Polish Patients

Pruski,

Millert-Kalińska,

Łagiedo

et al. 2023

JCM

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The introduction of human papillomavirus vaccines revolutionized cervical cancer prevention. Our research hypothesis is that HPV vaccination affects the remission of HPV in cervical swabs. We provide a prospective, ongoing, 24-month, non-randomized study in HPV-positive women. We enrolled 60 patients with positive HPV swabs from the cervix (fifty-one vaccinated with the nine-valent vaccine against HPV and nine unvaccinated). Using an enzyme-linked immunosorbent assay, we determined IgG class antibodies of HPV in the patients’ serums. Persistent HPV infection after vaccination was significantly less frequent in the nine-valent vaccinated group (23.5%) compared to the control group (88.9%; p < 0.001). Antibody level after vaccination was significantly higher in the vaccinated patients compared to the control group. The reactive antibody level was seen in the case of all patients in the vaccinated group and one-third of the unvaccinated group (33.3%, n = 3). The vaccination of HPV-positive patients may increase the chance of HPV remission in cervical swabs and may be a worthwhile element of secondary prevention in HPV-positive patients.

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The incidence of cervical intraepithelial neoplasia in a population of pregnant women with an abnormal cytology

Cited by 2 publications

References 10 publications

Sensitivity and specificity of hr hPV E6/E7 mrna test in detecting cervical squamous intraepithelial lesion and cervical cancer

Sensitivity and specificity of hr hPV E6/E7 mrna test in detecting cervical squamous intraepithelial lesion and cervical cancer

Effect of HPV Vaccination on Virus Disappearance in Cervical Samples of a Cohort of HPV-Positive Polish Patients

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