The Incidence of Fungal Keratitis and Endophthalmitis Following Penetrating Keratoplasty

Keyhani, Kayvan; Seedor, John A.; Shah, Mahendra; Terraciano, A.J.; Ritterband, David C.

doi:10.1097/01.ico..0000138832.3486.70

Cited by 107 publications

(88 citation statements)

References 23 publications

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“…Another short series suggested a possible link between post-keratoplasty endophthalmitis and donor malignancy. 19 This was confirmed by a study by the Eye Bank Association of America, 20 which reported that hospitalization or cancer at the time of Abbreviations: DA, donor age (years); DTT, death-to-tissue retrieval time (hours); TRT, tissue retrieval-to-reception time (hours). It represents the likelihood for a given cornea to be suitable for transplantation according to donor age, death-to-tissue retrieval time, and tissue retrievalto-reception time.…”

Section: Discussionsupporting

confidence: 55%

Influencing factors on the suitability of organ-cultured corneas

Gavrilov

Borderie

Laroche

et al. 2010

Eye

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Section: Discussionsupporting

confidence: 55%

Influencing factors on the suitability of organ-cultured corneas

Gavrilov

Borderie

Laroche

et al. 2010

Eye

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“…However, it remains a major concern in corneal transplantation. [15][16][17][18][19][20] In the current study, postoperative bullous keratoplasty (9/14, 64.3%) was the major risk factor for keratitis due to ocular surface diseases with recurrent erosion of the epithelium. 21,22 Fusarium infection is the most common pathogen leading to cornea perforation (28.8%), followed by P. aeruginosa keratitis (21.4%).…”

Section: Resultsmentioning

confidence: 99%

Eye preservation tectonic graft using glycerol-preserved donor cornea

Hc¹,

Sj²,

Chao³

2012

Eye

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Aims To report the surgical outcome of tectonic graft using glycerol-preserved donor corneas to treat perforated keratitis. Methods The medical records were reviewed of all patients treated for perforated keratitis using glycerol-preserved corneas at a single institution between 1 July 2004 and 31 June 2010. The clinical features, precipitating factors, adjuvant therapies, and therapeutic outcomes were analyzed. Success was defined as re-epithelialization of the ocular surface without evisceration. Results Fourteen eyes from 14 patients (6 male and 8 female) were included. Age ranged from 58 to 84 years (average, 70.71±8.52 years) and the follow-up time ranged from 7 to 56 months (mean, 25.35 ± 16.84 months). The culture results showed five bacterial infections, five cases of fungal keratitis, and one mixed infection; the culture results were negative for three patients. Satisfactory anatomical integrity was obtained in eight grafts (57.14%) that healed with neovascularization. Six grafts (48.85%) showed delayed re-epithelialization and were repaired with conjunctival flaps to maintain ocular surface integrity. Three patients developed secondary glaucoma and received trans-scleral cyclophotocoagulation. Thirteen patients had satisfactory anatomical integrity without evisceration or exenteration, while one patient received evisceration at 39-month follow-up because of intractable glaucoma. Conclusions Glycerol-preserved donor corneas combined with anterior vitrectomy with or without conjunctival flaps may be effective substitutes for evisceration surgery in patients with perforated keratitis.

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“…Fungal infection following penetrating keratoplasty has a reported incidence rate of 0.16% [1,2]. The recent increase in Descemet's stripping automated endothelial keratoplasty (DSAEK) has been accompanied by an increase in postoperative fungal infection, and five cases have been reported [3][4][5][6].…”

Section: Introductionmentioning

confidence: 98%