The Incidence of Hepatocellular Carcinoma in Iran from 1996 to 2016: a Systematic Review and Meta-analysis

Hassanipour, Soheil; Mohammadzadeh, Majid; Mansour-Ghanaei, Fariborz; Fathalipour, Mohammad; Joukar, Farahnaz; Salehiniya, Hamid; Abdzadeh, Elham; Samadani, Ali Akbar; Nikbakht, Hossein-Ali; Arab‐Zozani, Morteza

doi:10.1007/s12029-019-00207-y

Cited by 13 publications

(14 citation statements)

References 38 publications

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“…Hepatitis C (HC) is the leading cause of chronic liver disease, which can progress to chronic hepatocellular carcinoma with a high level of economic burden [8][9][10][11][12][13][14]. HB has silent epidemiology, and it is a primary bloodborne infection worldwide [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Epidemiologic profile of viral hepatitis B and C in North of Iran: results from PERSIAN Guilan Cohort Study (PGCS)

et al. 2021

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Objective Hepatitis B (HB) and C (HC) are two severe viral infectious diseases with a deleterious impact on global health. This study aimed to evaluate the prevalence of HB and HC in the Prospective Epidemiological Research Studies of the Iranian Adults (PERSIAN) Guilan Cohort Study using immunological and molecular methods. Results The blood samples were obtained from 10,520 enrolled participants. Complete biochemical and hematological tests, as well as urine analysis, were assessed. The presence of HBsAg, anti-HBs, anti-HBc, and anti-HCV antibodies for all participant and HBeAg and anti-HBe antibodies for HB-positive patients were evaluated. Moreover, HB genomic DNA and HC genomic RNA were extracted from serum samples of HB-positive patients. The real-time PCR assay was employed to quantify the gene copies of hepatitis B and C viruses. HC genotyping was also performed. The prevalence of HB and HC was 0.24% (95% CI 0.16–0.35) and 0.11% (95% CI 0.06–0.19), respectively. Rural participants were significantly more HB-positive than the urban people (P = 0.045), while males were significantly more HC-positive than the females (P = 0.013). The prevalence of HB and HC in this area were lower than those of other geographical locations of Iran, which may be due to different lifestyles or other unknown reasons.

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Section: Introductionmentioning

confidence: 99%

Epidemiologic profile of viral hepatitis B and C in North of Iran: results from PERSIAN Guilan Cohort Study (PGCS)

et al. 2021

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“…8,13 Iran is located in a region with low risk of LC for both sexes. 11,14 According to the results of a meta-analysis in Iran from 1996 to 2016, the ASIR of LC was 1.66 for males and 1.25 for females. 14 Studies in 2012, based on all registered Iranian cancer cases, showed 1567 patients with LC.…”

Section: Introductionmentioning

confidence: 99%

“…11,14 According to the results of a meta-analysis in Iran from 1996 to 2016, the ASIR of LC was 1.66 for males and 1.25 for females. 14 Studies in 2012, based on all registered Iranian cancer cases, showed 1567 patients with LC. 13 The articles pointed to scattered results but reported that some provinces including Ardebil, Semnan, and Khuzestan had the highest incidence of LC in Iran.…”

Section: Introductionmentioning

confidence: 99%

Primary Liver Cancer in Golestan Province, Northeastern Iran: 13-Year Experience of Golestan Population-Based Cancer Registry (GPCR)

et al. 2021

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Background: Liver cancer (LC) is among the most common and fatal cancers worldwide. A four-fold increasing trend is reported for LC age-standardized mortality rate (ASMR) in Iran within 1990–2015. In the present study, we aimed to report the incidence rate of LC during the 13-year establishment of the Golestan population-based cancer registry (GPCR). Methods: Age-standardized incidence rate (ASIR) per 100000 person-years was calculated using CanReg5 software. The Joint point regression analysis was used to assess the temporal trends in incidence rate of LC. Results: During the study period, GPCR registered 575 of LC cases, of which 373 (64.9%) were men and 297 (51.6%) lived in rural areas. The mean (SD) age of LC in men and women were 60.3 (17.2) and 58.0 (17.1), respectively. The ASIR of LC was significantly higher in men than women (4.7 vs. 2.6; P value<0.01) and a minimal increasing trend in LC incidence was observed in both sexes. The incidence rate of LC was significantly higher in rural areas compared to the urbans (3.91 vs. 3.40; P value=0.04). In the last 13 years, rural population had a significant increasing trend in ASIR of LC (average annual percent change [AAPC]=7.85, P value=0.005). Conclusion: LC was more prevalent in men among both urban and rural populations. The results showed a significant increasing trend in rural areas that requires Golestan health care system to take action in controlling the burden of LC in rural areas.

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“…The hepatitis C virus (HCV) is the leading cause of chronic liver disease, which can lead to chronic hepatocellular carcinoma with a high economic burden [7][8][9][10][11][12][13]. It has silent epidemiology and, at the same time, is a primary blood-borne infection worldwide [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Epidemiologic profile of viral hepatitis B and C in North of Iran: Results from PERSIAN Guilan Cohort Study (PGCS)

Mansour‐Ghanaei

Joukar

Naghipour

et al. 2020

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Objective Hepatitis B (HBV) and C (HCV) viruses are two severe infectious diseases with a high global health impact. This study aimed to evaluate the prevalence of HBV and HCV in the Prospective Epidemiological Research Studies of the Iranian Adults (PERSIAN) Guilan Cohort Study through immunological and molecular methods. Results The blood samples were obtained from 10520 enrolled participants. Complete biochemical and hematological assessments plus urine analysis were done. The presence of HBsAg, anti-HBs, anti-HBc, and anti-HCV antibodies for all participants and HBeAg and anti-HBe antibody for HBV positive patients were evaluated. HBV genomic DNA and HCV genomic RNA were extracted from positive serum samples. The real-time PCR assay was done to quantify HBV and HCV genomes. HCV genotyping was also performed. The HBV and HCV prevalence was 0.24% (95% CI, 0.16% to 0.35%) and 0.11% (95% CI, 0.06% to 0.19%), respectively. Rural participants were significantly more HBV positive than urban peoples (P = 0.045) while male individuals were significantly more HCV positive than female participants (P = 0.013). Our detected HBV and HCV prevalence were lower than other cities/provinces of Iran, which may be due to lifestyle or other unknown reasons.

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The Incidence of Hepatocellular Carcinoma in Iran from 1996 to 2016: a Systematic Review and Meta-analysis

Cited by 13 publications

References 38 publications

Epidemiologic profile of viral hepatitis B and C in North of Iran: results from PERSIAN Guilan Cohort Study (PGCS)

Epidemiologic profile of viral hepatitis B and C in North of Iran: results from PERSIAN Guilan Cohort Study (PGCS)

Primary Liver Cancer in Golestan Province, Northeastern Iran: 13-Year Experience of Golestan Population-Based Cancer Registry (GPCR)

Epidemiologic profile of viral hepatitis B and C in North of Iran: Results from PERSIAN Guilan Cohort Study (PGCS)

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