The Incidence of IDDM in Seoul From 1985 to 1988

Ko, Kwang Wook; Yang, Sei Won; Cho, Nam H.

doi:10.2337/diacare.17.12.1473

Cited by 45 publications

(37 citation statements)

References 6 publications

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“…First, for the case-control association study, 119 type 1 diabetic patients were selected randomly from the Korean Seoul Registry (5,6,15). All patients MICA and type 1 diabetes were on insulin therapy upon hospital discharge, Ͻ15 years of age, and residents of Seoul at the time of disease onset.…”

Section: Subjectsmentioning

confidence: 99%

“…All patients MICA and type 1 diabetes were on insulin therapy upon hospital discharge, Ͻ15 years of age, and residents of Seoul at the time of disease onset. Their mean age was 13 years (range [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. The second group consisted of 134 nondiabetic control subjects with no family history of diabetes who were selected from the same geographical area.…”

Section: Subjectsmentioning

confidence: 99%

“…Our type 1 diabetic subjects were selected from a population-based incidence registry (15), and control subjects were selected randomly according to a standardized international protocol (30) and have been described previously (5,6), permitting precise estimates of population gene frequency. The genotype distribution for the control population was tested for HardyWeinberg equilibrium and was not different from that expected.…”

Section: Mica and Type 1 Diabetesmentioning

confidence: 99%

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MICA Polymorphism Is Associated With Type 1 Diabetes in the Korean Population

et al. 2001

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OBJECTIVE -Recent studies have demonstrated that MICA (major histocompatibility complex class I chain-related genes) on the short arm of the chromosome 6 are associated with susceptibility to various autoimmune diseases in Caucasians. The aim of our study was to investigate the role of MICA in type 1 diabetes susceptibility independent of the HLA DR-DQ polymorphism in genetically distinct Koreans. RESEARCH DESIGN AND METHODS -A total of 119 patients selected fromKorean Seoul type 1 diabetes registry and 134 nondiabetic unrelated control subjects were typed for exon 5 polymorphism of MICA in addition to HLA DR-DQ typing. A total of 52 simplex families of type 1 diabetes were also studied.RESULTS -The MICA microsatellite allele consisting of six repetitions of GCT/AGC (A6) was present at a significantly lower frequency in the diabetic patient group (P c Ͻ 0.01; P c = P value after Bonferroni correction) than in the control population. The MICA microsatellite allele consisting of four repetitions (A4) was present at a higher frequency in diabetic patients (P Ͻ 0.05). This deviated distribution was not changed even after controlling for the HLA DRB1-DQB1 haplotype. Transmission/disequilibrium test revealed significant deviation of transmission for alleles at the A6 polymorphism within the MICA gene (P Ͻ 0.05).CONCLUSIONS -We could assess that the MICA gene might be associated with type 1 diabetes transracially independent of the HLA gene.

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Section: Subjectsmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

Section: Mica and Type 1 Diabetesmentioning

confidence: 99%

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MICA Polymorphism Is Associated With Type 1 Diabetes in the Korean Population

et al. 2001

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“…Similarly, it was also reported that only 1.7 % (2 of 121) of previously undetected Type II diabetic patients in Korea had anti-GAD antibody [28]. Taken together with the finding that the incidence of Type I (insulin-dependent) diabetes in Japan and Korea is among the lowest in the world [29,30], these results suggest that autoimmunity might not be a major cause of diabetes in this country.…”

Section: Discussionmentioning

confidence: 69%

Islet cell autoimmunity and mitochondrial DNA mutation in Korean subjects with typical and atypical Type I diabetes

Lee

Palmer

et al. 2001

Diabetologia

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“…Furthermore, it is difficult to perform studies regarding type 1 diabetes mellitus in Asia, including Korea and Japan, due to the low incidence of type 1 diabetes mellitus [17,18]. Therefore, it is uncertain how many patients with type 1 diabetes in Korea ing the greatest r value for the correlation with other indexes was considered to be the best parameter.…”

Section: Measurements and Data Analysismentioning

confidence: 99%

Assessment of glycemic lability and severity of hypoglycemia in Korean patients with type 1 diabetes

et al. 2011

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Pancreas or islet transplantation is recommended for individuals with type 1 diabetes who present with frequent and severe hypoglycemia and/or severe glycemic lability, despite efforts to optimize glycemic control [1]. For these patients, pancreas or islet transplantation has led to successful treatment of these problems [2][3][4]. Pancreas and islet transplantations have previously been performed in Korea [5,6].Clinicians can judge whether patients with type 1 diabetes have problems with glycemic lability and/or severe hypoglycemia, but it is difficult to quantify the glycemic lability and hypoglycemia.Attempts have been made to quantify both hypoglycemia and glycemic lability to allow for betweenAssessment of glycemic lability and severity of hypoglycemia in Korean patients with type 1 diabetes abstract. Few studies have focused on the quantification of glycemic lability and hypoglycemic events in Asian patients with type 1 diabetes; therefore, we conducted a study to assess glycemic lability and the severity of hypoglycemia in type 1 diabetic patients in Korea. A total of 124 type 1 diabetic patients were enrolled. Several glycemic lability indexes and hypoglycemic indexes were calculated using four-week self-monitoring of blood glucose (SMBG) data. Due to the dependence of the lability index (LI) on the frequency of glucose measurements, we generated a modified LI by dividing by the number of SMBG measurements per day for a given patient. The numbers of patients in our study with a composite hypoglycemic score ≥ 1,047 or LI ≥ 433 mmol/L 2 /h·week -1 , which was found in a previous study to indicate high risk of severe hypoglycemia or lability, were 0 (0%) and 44 (35%), respectively. Compared to previously reported hypoglycemia indexes, the low blood glucose index was lower in our study. However, the glycemic lability indexes were similar to those in previous studies, with the exception of the LI. The modified LI and the average daily risk range (ADRR) showed higher concordance with other glycemic lability indexes than did the LI or mean amplitude of glycemic excursions (MAGE). The results showed that the hypoglycemic indexes in this study population were lower than the results from Ryan et al. Furthermore, the ADRR or modified LI were better measures for high risk of severe lability than were the LI and MAGE.Key words: Glycemic lability, Type 1 diabetes mellitus, Hypoglycemia center comparison as well as to establish standards for pancreas or islet transplantation [7]. Several indexes have been proposed for glycemic lability and hypoglycemia. The most familiar assessment of glycemic lability is the standard deviation (SD) of the glucose profile [8]. However, the SD has limited capacity to identify the extremes of hyperglycemia or hypoglycemia and is affected by the mean glucose [9]. The mean amplitude of glycemic excursions (MAGE) and average daily risk range (ADRR) also measure glucose lability in diabetic patients [10,11]. The MAGE using continuous glucose monitoring is a well-known index of glycemic labil...

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The Incidence of IDDM in Seoul From 1985 to 1988

Cited by 45 publications

References 6 publications

MICA Polymorphism Is Associated With Type 1 Diabetes in the Korean Population

MICA Polymorphism Is Associated With Type 1 Diabetes in the Korean Population

Islet cell autoimmunity and mitochondrial DNA mutation in Korean subjects with typical and atypical Type I diabetes

Assessment of glycemic lability and severity of hypoglycemia in Korean patients with type 1 diabetes

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