Background: According to the literature, the incidence of kidney cancer is on the rise worldwide. Objectives: The aim of this investigation was to provide the data of period prevalence of kidney, renal pelvis, and ureter cancers in the general population including the military or non-military population in Isfahan province, Iran. Methods: Data associated with cancers of the kidney, renal pelvis, and ureter were obtained from the Isfahan Cancer Registry between 2011 and 2015. Kidney, renal pelvis, and ureter cancers were defined by topography codes of C64, C65, and C66, respectively. Results: There were 404, 21, and 18 registered cases of kidney, renal pelvis, and ureter cancers, respectively, corresponding to a PP of 8.9 per 100000 population. The mean ± SD of age was 56.6 ± 16.8 years in patients. The age of kidney cancer patients was more than 50 years in 51% of the cases. The incidences were 2per 100000 population. The death data confirmed 14% and 86% mortality associated with kidney cancer and renal pelvis, respectively. Conclusions: The incidence rate of kidney cancer showed increases by 20%. The data confirmed high mortality associated with cancer of renal pelvis. In order to decrease cancer incidence, healthcare planning should be based on military management together with a well-structured pharmacotherapy strategy.