The incidence of metabolic syndrome in adolescents with different phenotypes of PCOS

Abstract

Objectives: To evaluate the incidence of metabolic syndrome in Turkish adolescents with different phenotypes of polycystic ovary syndrome (PCOS). Material and methods:This cross-sectional study was performed on the Youth Center clinic of a tertiary referral hospital in Turkey. Adolescents with PCOS (n = 144) were classified into four phenotype groups according to the presence of oligo/anovulation (O), hyperandrogenism (H), and polycystic ovarian morphology (P) as follows: Phenotype A (O + H + P), Phenotype B (H + O), Phenotype C (H + P), Phenotype D (O + P). The adolescents gave early follicular phase blood samples for endocrine and metabolic tests. The incidence and the presence of parameters of metabolic syndrome were assessed among the four groups. Results:In total, 54.9% of the adolescents with PCOS were overweight and 25.7% had metabolic syndrome. The incidence of metabolic syndrome in Phenotypes A-D were as follows: 39.5%, 20.5%, 26.5%, and 15.2%, respectively. Although body mass index was higher in the Phenotype A group, insulin resistance was similar in all of the phenotype groups. The most common dyslipidemia was low HDL-C levels and this was present in more than half of the adolescents with PCOS. Both body mass index and total testosterone levels were significantly higher in adolescents with metabolic syndrome in comparison to those without metabolic syndrome. Conclusions:Although low HDL-C levels and insulin resistance are common PCOS findings in adolescents, the metabolic profile seems to be worse in Phenotype A than the other phenotypes. Therefore, screening programs should evaluate patients based on the known risk factors and phenotypes for adolescents with PCOS.

Androgen signaling pathways driving reproductive and metabolic phenotypes in a PCOS mouse model

“…PCOS patients can be divided into four phenotypes (A-D) based on the presence of the Rotterdam diagnostic criteria (Lizneva et al 2016). Interestingly, nonhyperandrogenic PCOS patients (phenotype D) are reported to display a lower risk of developing metabolic PCOS traits than the other three hyperandrogenic PCOS phenotypes (Zhang et al 2009, Kar 2013, Clark et al 2014, Altintas et al 2017, Tripathy et al 2018. Therefore, this raises the question of whether non-hyperandrogenic PCOS patients are etiologically distinct from women with PCOS who display hyperandrogenism (Azziz et al 2006(Azziz et al , 2009.…”

SARS-CoV-2 Viral Entry Proteins in Hyperandrogenemic Female Mice: Implications for Women with PCOS and COVID-19

“…However, those relationships have not been evaluated on a larger scale to assess hospitalizations or death. Interestingly, circulating androgens in women with PCOS are positively associated with the severity of metabolic dysfunction and obesity [ 25 , 26 , 27 , 28 ], both being well-recognized comorbidities in the severity of COVID-19 [ 29 ].…”

Is polycystic ovarian syndrome and insulin resistance associated with abnormal uterine bleeding in adolescents?

“…Heavy menstrual bleeding occurs frequently and can significantly impair the quality of life of adolescent females. Thorough analysis and research can help in revealing the causes of abnormal bleeding and prevent intensification of co-endocrine disorders such as acne, hirsutism, PCOS, metabolic syndrome and insulin resistance in future life [12][13][14][15][16].…”