The incidence of unprovoked seizures and occurrence of neurodevelopmental comorbidities in children at the time of their first epileptic seizure and during the subsequent six months

Åndell, Eva; Tomson, Torbjörn; Carlsson, Sofia; Hellebro, Eva; Andersson, Tomas; Adelöw, Cecilia; Åmark, Per

doi:10.1016/j.eplepsyres.2015.04.002

Cited by 29 publications

(25 citation statements)

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“…Knowledge about coexisting developmental, psychiatric, cognitive disorders in children with epilepsy has increased, and several studies have shown that epilepsy is very often combined with ADHD, autism spectrum disorder and, or intellectual disability (ID) . Comorbidities, such as ADHD, have been reported especially in early onset epilepsy .…”

Section: Introductionmentioning

confidence: 99%

Cognitive functioning in a representative cohort of preschool children with febrile seizures

et al. 2019

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Aim: To analyse cognitive functioning in 4-5-year-old children who had experienced febrile seizures (FS) and to assess the importance of complex, recurrent and early vs late onset FS. Methods: The sample consisted of 73 children, screen positive for FS, drawn from the general child population of 4-year-old children attending their health check-up at child healthcare centres in Gothenburg, Sweden. They were assessed as regards general cognitive ability, visual memory and attention and were contrasted with age norms and with results obtained in 20 children without FS from the same healthcare centres.Results: Of the 73 children, two had a previously diagnosed intellectual disability (ID) (one mild, one moderate) and two further children tested within the study had results corresponding to mild ID. Children with early onset of FS (before age 12 months)who often had recurrent FS-had lower full-scale, verbal and processing speed IQ than those who had later onset of FS. Conclusion:Children with early onset of FS and particularly those with recurrent FS may be at increased risk for poorer verbal and processing speed functioning and therefore at risk of developing cognitive, executive dysfunctions. They would probably benefit from neuropaediatric and neuropsychological follow-up. K E Y W O R D S cognitive test data, febrile seizures, IQ, preschool children, processing speed How to cite this article: Billstedt E, Nilsson G, Leffler L, et al. Cognitive functioning in a representative cohort of preschool children with febrile seizures. Acta Paediatr. 2020;109:989-994. https ://doi.

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Section: Introductionmentioning

confidence: 99%

Cognitive functioning in a representative cohort of preschool children with febrile seizures

et al. 2019

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“…Many types of childhood epilepsy are part of broader neurodevelopmental disorders that are known to be associated with neuropsychiatric disorders such as ASD. 14,15 Epilepsy with onset later in life has etiologies (e.g., stroke and dementias) different from childhood-onset epilepsy. This might explain the lower relative risk of ASD in older individuals with epilepsy.…”

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confidence: 99%

Autism and epilepsy

et al. 2016

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Objective: To investigate the risk of autism spectrum disorder (ASD) in individuals with epilepsy and in their first-degree relatives to determine shared etiology.Methods: Through the Swedish Patient Register, we identified 85,201 individuals with epilepsy, as well as all their siblings (n 5 80,511) and offspring (n 5 98,534). Each individual with epilepsy was compared with 5 controls, matched for age, sex, calendar period, and county, while siblings and offspring were compared with siblings and offspring of controls. We excluded siblings and offspring with epilepsy. Using Cox regression, we calculated hazard ratios (HRs) for future diagnosis of ASD. Logistic regression was applied to calculate odds ratios (ORs) for prior diagnosis of ASD.Results: During follow-up, 1,381 (1.6%) individuals with epilepsy and 700 (0.2%) controls were diagnosed with ASD. Individuals with epilepsy were therefore at increased risk of future ASD (HR 10.49, 95% confidence interval [CI] 9.55-11.53), with the highest risk seen in individuals diagnosed with epilepsy in childhood. Both siblings (HR 1.62, 95% CI 1.43-1.83) and offspring (HR 1.64, 95% CI 1.46-1.84) of epilepsy patients were at increased risk of ASD. The risk in the offspring was particularly high in mothers with epilepsy (HR 1.91; 95% CI 1.63-2.23). Epilepsy was also associated with a prior diagnosis of ASD (OR 4.56, 95% CI 4.02-5.18). According to the definition of the International League Against Epilepsy, "epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures and by the neurobiologic, cognitive, psychological, and social consequences of this condition." Conclusions:1 Epilepsy frequently co-occurs with psychiatric disturbances, such as mood and anxiety disorders and autism spectrum disorder (ASD). 1 ASD is a neurodevelopmental disorder characterized by impairment in social interaction and communication and restricted, repetitive, or stereotypic behavior, interests, and activities. The strength and nature of the association between epilepsy and ASD have been scarce and difficult to interpret. A US study of health care data, a British psychiatric morbidity survey, and a prospective screening study all found that ASD as a comorbidity in patients with epilepsy had a prevalence between 1.3% and 21% and an odds ratio (OR) between 6 and 22.

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“…In this context it is noteworthy that incidence rates in children appear lower than previous salient estimates. 8,10,19,20 …”

Section: Discussionmentioning

confidence: 99%

Epidemiology of First Epileptic Seizures in the Northern Aegean Island of Lesvos, Greece

Verentzioti

Stranjalis

Κalamatianos

et al. 2017

Clinics and Practice

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We aimed at establishing the epidemiologic profile of first epileptic seizures (FES) in the Greek island of Lesvos. During a 1-year period (01/06/2010 to 31/05/2011), cases of FES admitted to the Lesvos General Hospital/addressed by general practitioners/private neurologists were prospectively identified. A total of 45 cases (30 males and 15 females; mean age ± SD of 59.4 ± 28.4 and 58.9 ± 26.8 years, respectively), were collected. The FES incidence rate was 52.1 (95% CI 37-67) per 105 persons. Provoked and unprovoked FES had an incidence of, 16.2 and 35.9 cases per 105 persons, respectively. Following age-adjustment to the 2000 US census population, incidence rates of FES (all types combined) were, 40.5 (95% CI 28-56) per 105 persons. Cerebrovascular disease (CVD) was the most prevalent etiologic factor. The present findings indicate a low-ranking incidence of FES in the studied population and highlight CVD as a leading causative factor.

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The incidence of unprovoked seizures and occurrence of neurodevelopmental comorbidities in children at the time of their first epileptic seizure and during the subsequent six months

Cited by 29 publications

References 52 publications

Cognitive functioning in a representative cohort of preschool children with febrile seizures

Cognitive functioning in a representative cohort of preschool children with febrile seizures

Autism and epilepsy

Epidemiology of First Epileptic Seizures in the Northern Aegean Island of Lesvos, Greece

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