The incidence of uterine leiomyoma and other pelvic ultrasonographic findings in 2,034 consecutive women in a north London hospital

Selo-Ojeme, Dan; Lawal, Oluwafemi Oluwasegun; Shah, Jagruti M.; Mandal, Rajesh Kumar; Pathak, Samrendra Nath; Selo-Ojeme, U; Samuel, D

doi:10.1080/01443610802149863

Cited by 26 publications

(18 citation statements)

References 10 publications

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“…Development of myomas increases drastically throughout the subsequent decades of age, reaching 60% within the range between 40 and 60 years [11, 12]. Relation between obesity and augmented risk of myoma has now been well documented.…”

Section: Introductionmentioning

confidence: 99%

Receptors of Hypothalamic-Pituitary-Ovarian-Axis Hormone in Uterine Myomas

Plewka

Marczyński

Morek

et al. 2014

BioMed Research International

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In this study the expression of GnRH, FSH, LH, ER-α, ER-β, and PR receptors was examined in uterine myomas of women in reproductive and perimenopausal age. In cases of GnRH and tropic hormones a membranous and cytoplasmic immunohistochemical reaction was detected, in cases of ER-α and PR the reaction was located in cell nucleus, and in the case of ER-β it manifested also a cytoplasmic location. In some of the examined cases the expression was detected in endometrium, myocytes, and endothelium of blood vessels, in uterine glands and myoma cells. In myometrium the level of GnRH and LH receptors increases with age, whereas the level of progesterone and both estrogen receptors decreases. In myomas of women in reproductive age, independently of their size, expression of GnRH, FSH, and LH receptors was more pronounced than in myometrium. In women of perimenopausal age, independently of myoma size, expression of LH and estrogen α receptors was higher while expression of GnRH receptors was lower than in myometrium. FSH receptor expression was not observed. Expression of estrogen receptor β was not affected by age of the woman or size of myoma. Analysis of obtained results indicates on existing in small myomas local feedback axis between GnRH-LH-progesterone.

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Section: Introductionmentioning

confidence: 99%

Receptors of Hypothalamic-Pituitary-Ovarian-Axis Hormone in Uterine Myomas

Plewka

Marczyński

Morek

et al. 2014

BioMed Research International

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“…Uterine leiomyomata are highly prevalent, fibrotic tumors of the uterus that disproportionally afflict African American women and are a public health concern (Day Baird et al, 2003; Walker and Stewart, 2005; Lee et al, 2007; Selo-Ojeme et al, 2008; Laughlin et al, 2009). Previously, we (Catherino et al, 2004; Leppert et al, 2004), and others (Wolanska et al, 1998; Mitropoulou et al, 2001; Wolanska et al, 2003; Behera et al, 2007) have shown the ECM of leiomyoma to be increased in amount and altered in composition, compared to the ECM of the uterine myometrium.…”

Section: Introductionmentioning

confidence: 99%

Characterization of tissue biomechanics and mechanical signaling in uterine leiomyoma

Norian¹,

Owen²,

Taboas

et al. 2012

Matrix Biology

103

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Leiomyoma are common tumors arising within the uterus that feature excessive deposition of a stiff, disordered extracellular matrix (ECM). Mechanical stress is a critical determinant of excessive ECM deposition and increased mechanical stress has been shown to be involved in tumorigenesis. Here we tested the viscoelastic properties of leiomyoma and characterized dynamic and static mechanical signaling in leiomyoma cells using three approaches, including measurement of active RhoA. We found that the peak strain and pseudo-dynamic modulus of leiomyoma tissue was significantly increased relative to matched myometrium. In addition, leiomyoma cells demonstrated an attenuated response to applied cyclic uniaxial strain and to variation in substrate stiffness, relative to myometrial cells. However, on a flexible pronectin-coated silicone substrate, basal levels and lysophosphatidic acid-stimulated levels of activated RhoA were similar between leiomyoma and myometrial cells. In contrast, leiomyoma cells plated on a rigid polystyrene substrate had elevated levels of active RhoA, compared to myometrial cells. The results indicate that viscoelastic properties of the ECM of leiomyoma contribute significantly to the tumor’s inherent stiffness and that leiomyoma cells have an attenuated sensitivity to mechanical cues. The findings suggest there may be a fundamental alteration in the communication between the external mechanical environment (extracellular forces) and reorganization of the actin cytoskeleton mediated by RhoA in leiomyoma cells. Additional research will be needed to elucidate the mechanism(s) responsible for the attenuated mechanical signaling in leiomyoma cells.

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“…: fibroids) are among the most frequent clinically relevant human tumors leading, e.g., to abdominal pain, bleeding and infertility. Their prevalence clearly differs depending on ethnicity but in most countries exceeds 50% of all women in their reproductive ages 1, 2. The monoclonal origin of fibroids3–6 suggests mutations of myometrial target cells as the cause of the disease.…”

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confidence: 99%

MED12 mutations in uterine fibroids—their relationship to cytogenetic subgroups

Markowski

Bartnitzke

Löning

et al. 2012

Intl Journal of Cancer

193

168

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Recurrent chromosomal alterations are found in roughly 20% of all uterine fibroids but in the majority cytogenetic changes are lacking. Recently, mutations of the gene mediator subcomplex 12 (MED12) have been detected in a majority of fibroids but no information is available whether or not they co-occur with cytogenetic subtypes as, e.g., rearrangements of the genes encoding high mobility group AT-hook (HMGA) proteins. In a total of 80 cytogenetically characterized fibroids from 50 patients, we were not only able to confirm the frequent occurrence of MED12 mutations but also to stratify two mutually exclusive pathways of leiomyomagenesis with either rearrangements of HMGA2 reflected by clonal chromosome abnormalities affecting 12q14~15 or by mutations affecting exon 2 of MED12. On average the latter mutations were associated with a significantly smaller tumor size. However, G>A transitions of nucleotides c.130 or c.131 correlate with a significantly larger size of the fibroids compared to other MED12 mutations thus explaining the high prevalence of the former mutations among clinically detectable fibroids. Interestingly, fibroids with MED12 mutations expressed significantly higher levels of the gene encoding wingless-type MMTV integration site family, member 4 (WNT4). Based on these findings and data from the literature, we hypothesize that estrogen and the mutated MED12 cooperate in activating the Wnt pathway which in turn activates b-catenin known to cause leiomyoma-like lesions in a mouse model. The occurrence of a ''fibroid-type mutation'' in a rare histologic subtype of endometrial polyps suggests that this mechanism is not confined to uterine leiomyomas.Uterine leiomyomas (syn.: fibroids) are among the most frequent clinically relevant human tumors leading, e.g., to abdominal pain, bleeding and infertility. Their prevalence clearly differs depending on ethnicity but in most countries exceeds 50% of all women in their reproductive ages.

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The incidence of uterine leiomyoma and other pelvic ultrasonographic findings in 2,034 consecutive women in a north London hospital

Cited by 26 publications

References 10 publications

Receptors of Hypothalamic-Pituitary-Ovarian-Axis Hormone in Uterine Myomas

Receptors of Hypothalamic-Pituitary-Ovarian-Axis Hormone in Uterine Myomas

Characterization of tissue biomechanics and mechanical signaling in uterine leiomyoma

MED12 mutations in uterine fibroids—their relationship to cytogenetic subgroups

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