The incidence rate of cancer in patients with schizophrenia: A meta-analysis of cohort studies

Li, Hailong; Li, Jiasi; Yu, Xiuchong; Zheng, Huiwen; Sun, Xu; Lü, Yue; Zhang, Yanbo; Li, Chunbo; Bi, Xiaoying

doi:10.1016/j.schres.2017.08.065

Cited by 64 publications

(77 citation statements)

References 48 publications

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“…Another meta-analysis based on 16 cohort studies showed a high risk of cancer mortality in individuals with schizophrenia [12]. Different from the results of subgroup analysis stratified by cancer type [25], Zhuo et al described that female schizophrenia faced a higher incidence of breast cancer than the general population in a meta-analysis published in 2018 [26]. Therefore, the association between cancer incidence and mortality risk in patients with schizophrenia remains vague on account of several potential confounding factors, such as gender, ethnicity, genetic background, cancer site, antipsychotic medication use, and cancer care [27,28].…”

Section: Main Findings and Comparison With Other Studiesmentioning

confidence: 87%

“…The conclusion of our study was that patients with schizophrenia have a higher risk of mortality from common site-specific cancers was validated, particularly by a significantly high risk of mortality from breast, lung, and colon cancer and a high risk of mortality from prostate cancer. A previous metaanalysis showed no significant relationships between schizophrenia and breast and lung cancer prevalence; it also revealed that patients with schizophrenia have low incidence risk of colorectal and prostate cancer [25].…”

Section: Main Findings and Comparison With Other Studiesmentioning

confidence: 92%

“…Johnston et al found that two hyperprolactinemia-inducing antipsychotics, risperidone and pimozide, incite precancerous cells to progress to cancer by activating JAK-STAT5 signaling [32]. Patients with schizophrenia show decreased incidence of prostate cancer [25,33], which is theoretically related to low testosterone levels suppressed by high prolactin levels on account of antipsychotic drug use [34]. A case-control study revealed that the reduced risk of prostate cancer among patients with schizophrenia is likely associated with long-term treatment of high-dose phenothiazines (primarily chlorpromazine) [35].…”

Section: Main Findings and Comparison With Other Studiesmentioning

confidence: 99%

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Mortality of site-specific cancer in patients with schizophrenia: A systematic review and meta-analysis

Long

Yuan

et al. 2019

Preprint

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Background: Numerous studies have reported contradicting results on the relationship between cancer mortality and schizophrenia. Our aim is to quantify the mortality rate of common site-specific cancers among patients with schizophrenia and to synthesize the available research evidence. Method: We performed a systemic search of the PubMed, EMBASE and Web of Science databases. Studies reporting the mortality rate of different cancer in patients with schizophrenia were included. A random-effects model was applied to calculate the pooled relative risks (RRs) with 95% confidence intervals (95%CIs). Results: Seven studies consisting of a total of 1,162,971 participants with schizophrenia were included in this meta-analysis. Data regarding mortality risk of breast, colon, lung and prostate cancer among schizophrenia patients were subjected to quantitative analysis. Pooled results showed significant increases in mortality risk of breast cancer (RR = 1.97, 95%CI 1.38–2.83), lung cancer (RR = 1.93, 95%CI 1.46–2.54) and colon cancer (RR = 1.69, 95%CI 1.60–1.80) in patients with schizophrenia compared with those in the general population or control group. The mortality risk of prostate cancer increased in male patients, although no significant difference was detected (RR = 1.58, 95% CI 0.79–3.15). Increased risks of mortality from lung and colon cancer were observed in female patients (RR = 2.49, 95%CI 2.40–2.59 and RR = 2.42, 95%CI 1.39–4.22, respectively) and elevated risks of mortality from lung and colon cancer in male patients (RR = 2.40, 95%CI 2.30–2.50 and RR = 1.90, 95%CI 1.71–2.11, respectively) were detected. Conclusions: Individuals with schizophrenia have a significantly high risk of mortality from breast, colon, and lung cancer and a high risk of mortality from prostate cancer.

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Section: Main Findings and Comparison With Other Studiesmentioning

confidence: 87%

Section: Main Findings and Comparison With Other Studiesmentioning

confidence: 92%

Section: Main Findings and Comparison With Other Studiesmentioning

confidence: 99%

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Mortality of site-specific cancer in patients with schizophrenia: A systematic review and meta-analysis

Long

Yuan

et al. 2019

Preprint

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“…The analysis environment was the Meta-MUMS tool as a comprehensive meta-analysis tool without any limitations in number size and data entry (9,10). Analysis of dichotomous data was done with a 95% confidence interval to set lower and upper limits based on risk ratio (RR) as well as event rate (ER) when no interventions are involved (11). In all calculations and analyses, the p-values less than 0.05 were statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Comparative Global Epidemiological Investigation of SARS-CoV-2 and SARS-CoV Diseases Using Meta-MUMS Tool Through Incidence, Mortality, and Recovery Rates

Sokouti

Sadeghi

Pashazadeh

et al. 2020

Archives of Medical Research

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As an unexplained respiratory disease epidemic, which is similar to respiratory syndrome coronavirus SARS-CoV, it rapidly spread all over the world. The study aims to compare several parameters of COVID-19 and SARS-CoV infectious diseases in terms of incidence, mortality, and recovery rates. The publicly available dataset Worldometer (extracted on April 5, 2020) confirmed by WHO report was available for meta-analysis purposes using the Meta-MUMS tool. And, the reported outcomes of the analysis used a random-effects model to evaluate the event rate, and risk ratios thorough subgroup analysis forest plots. Seventeen countries for COVID-19 and eight countries of SARS infections, including COVID-19 group n 5 1124243, and SARS-CoV group n 5 8346, were analyzed. In this meta-analysis, a random effect model of relations of incidence, mortality, and recovery rates of COVID-19 and SARS world infections were determined. The meta-analysis and forest plots of two viral world infections showed that the incidence rate of COVID-19 infection is more than SARS infections, while recovery and mortality event rates of SARS-CoV are more than COVID-19 infection. And subgroup analysis showed that the mortality and recovery rates were higher in both SARS-CoV wand COVID-19 in comparison to incidence and mortality rates, respectively. In conclusion, the meta-analysis approach on the abovementioned dataset revealed the epidemiological and statistical analyses for comparing COVID-19 and SARS-CoV outbreaks. Ó 2020 IMSS. Published by Elsevier Inc.

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“…In recent years, numerous meta-analyses are published by pooling the data from different world regions and countries to study the trend of incidence for a specific disease or event of interest. A pooled risk ratio is derived and analyzed by sex and age groups (Li et al 2018). Sex-and site-specific all-ages new cancer incidences and cancer deaths are estimated, and uncertainty intervals to take into account possible sources of bias are provided (Ferlay et al 2018).…”

mentioning

confidence: 99%

Analysis of incidence rates

2020

Journal of Biopharmaceutical Statistics

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The incidence rate of cancer in patients with schizophrenia: A meta-analysis of cohort studies

Cited by 64 publications

References 48 publications

Mortality of site-specific cancer in patients with schizophrenia: A systematic review and meta-analysis

Mortality of site-specific cancer in patients with schizophrenia: A systematic review and meta-analysis

Comparative Global Epidemiological Investigation of SARS-CoV-2 and SARS-CoV Diseases Using Meta-MUMS Tool Through Incidence, Mortality, and Recovery Rates

Analysis of incidence rates

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