The incidence rate of diabetes mellitus (type II) and its related risk factors: A 10-year longitudinal study of Yazd Healthy Heart Cohort (YHHC), Iran

Namayandeh, Seyedeh Mahdieh; Karimi, Ahmad; Fallahzadeh, Hossein; Rahmanian, Masoud; Bafghi, S M Sadr; Soltani, Mohammadhosein; Hadiani, Leila

doi:10.1016/j.dsx.2019.02.012

Cited by 17 publications

(18 citation statements)

References 12 publications

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“…Also, T2D was significantly associated with high BMI as a diabetes risk factor and other factors including age, being female, and education (Rashedi et al 2017). Other studies conducted in this area revealed the high incidence and prevalence of T2D in Iran (Ebrahimi et al 2016;Yazdanpanah et al 2016;Namayandeh et al 2019). Table 2 represents the association of PM 2.5 value with diabetes and prediabetes prevalence and their main related risk factors.…”

Section: Resultsmentioning

confidence: 95%

Association between exposure to ambient fine particulate matter and prevalence of type 2 diabetes in Iran: an ecological study

Janjani

Nabizadeh

Shamsipour

et al. 2020

Environ Sci Pollut Res

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Epidemiological evidence for the link between long-term exposure to air particulate matter (PM 2.5) and occurrence of type 2 diabetes (T2D) is limited such that little is known about the effect of PM 2.5 exposure and adult T2D prevalence. Thus, the aim of this ecological study is to evaluate the contribution of ambient PM 2.5 exposure to the adult T2D prevalence in the large population of Iran. The study was conducted based on Iran's large-scale cross-sectional surveilling non-communicable diseases (NCDs) risk factors (Timpka et al. 2015b). A total of 31,050 participants were enrolled in three sequential processes of study using cluster random sampling. PM 2.5 data in the urban area of 31 provinces of Iran were acquired from Tehran Air Quality Control Company (AQCC) and the Department of Environment (DoE) of Iran during 2012-2016. Moreover, major and minor diabetes risk factors were considered; the Pearson correlation and a stepwise regression model were performed to estimate associations between risk factors and diabetes and prediabetes prevalence. The results showed T2D prevalence was more frequent among women (10.61%) than men (9.35%). A weak positive correlation was observed between PM 2.5 level and diabetes prevalence with a correlation coefficient of 0.275, although there was no significant association between PM 2.5 value and prediabetes prevalence. Moreover, none of the variables included in the regression model could predict the prevalence of diabetes and prediabetes. According to our study results, it can be suggested that investigating the association between PM 2.5 exposure and T2D prevalence at individual level may provide a better understanding of PM 2.5 exposure and the risk of T2D prevalence.

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Section: Resultsmentioning

confidence: 95%

Association between exposure to ambient fine particulate matter and prevalence of type 2 diabetes in Iran: an ecological study

Janjani

Nabizadeh

Shamsipour

et al. 2020

Environ Sci Pollut Res

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“…Similarly, the risk of diabetes in a Singaporean population elevated progressively across TyG index quartiles (Q) from Q1 to Q4 (Q4 vs. Q1; adjusted HR 5.30, 95% CI 2.21-12.71) [20]. However, potential confounders, such as serum lipid index (LDL-C and TC), drinking, smoking and family history of diabetes, were not su ciently adjusted, and were notablely relevant to high risk of diabetes [26][27][28][29][30][31]. Fortunately, these confounding factors were taken into consideration in this study to avoid potential effects on the results.…”

Section: Discussionmentioning

confidence: 99%

Association between triglyceride-glucose index and risk of incident diabetes: a secondary analysis based on a Chinese cohort study

Tien

et al. 2020

Preprint

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Background: Recent studies have suggested the triglyceride-glucose index (TyG index) may serve as a suitable substitute for insulin resistance. However, evidence for the relationship between TyG index and risk of diabetes remains limited. This study sought to explore the association of baseline TyG index with risk of developing diabetes in Chinese adults.Methods: This retrospective cohort study was conducted using data from the health screening program in China. A total of 201,298 non-diabetic individuals were included. TyG index was calculated as Ln [fasting plasma glucose (mg/dl) × fasting triglyceride level (mg/dl)/2]. Diabetes was defined as fasting plasma glucose ≥126 mg/dl and/or self-reported diabetes. Cox proportion-hazard model was employed to evaluate the independent impact of baseline TyG index on future diabetes risk. Sensitivity and subgroup analyses were implemented to verify the reliability of results. Notably, data were downloaded from the DATADRYAD website, and used only for secondary analyses.Results: During an average follow-up of 3.12 years, among 201,298 individuals aged ≥20 years, 3,389 subjects developed diabetes. After adjusting for potential confounders, elevated TyG index were independently correlated with greater risk of incident diabetes (hazard ratio (HR), 3.34; 95% confidence interval (CI), 3.11–3.60). Compared with the lowest quartile (Q1), increasing TyG index (Q2, Q3, and Q4) was related to increased HR estimates of incident diabetes [HR (95% CI), 1.83 (1.49–2.26); 3.29 ( 2.70–4.01), and 6.26 (5.15–7.60), respectively]. Moreover, a nonlinear relationship was observed between TyG index and risk of diabetes and the slope of the curve increased accompanying the rise of TyG index. Subgroup analysis revealed the positive association was stronger among subjects with age < 40 years, body mass index ≥18.5 kg/m2 and < 24 kg/m2, or systolic blood pressure <140 mmHg, or in females.Conclusions: Elevated TyG index is independently correlated with increased risk of incident diabetes in Chinese adults, indicating it may represent a reliable predictor of diabetes in high-risk populations.

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“…Besides, IR is largely attributable to the impairment of insulin-stimulated glucose absorption into skeletal muscle. When TG levels in peripheral blood and skeletal muscle were signi cantly increased, glucose metabolism in skeletal muscle would be impaired [46]. Therefore, to a certain extent, the TyG index re ects muscle IR [47].…”

Section: Discussionmentioning

confidence: 99%

Association Between Triglyceride-Glucose Index and Risk of Incident Diabetes: A Secondary Analysis Based on A Chinese Cohort Study

Tien

et al. 2020

Preprint

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Background: Recent studies have suggested the triglyceride-glucose index (TyG index) may serve as a suitable substitute for insulin resistance. However, evidence for the relationship between TyG index and risk of diabetes remains limited. This study sought to explore the association of baseline TyG index with risk of developing diabetes in Chinese adults.Methods: This retrospective cohort study was conducted using data from the health screening program in China. A total of 201,298 non-diabetic individuals were included. TyG index was calculated as Ln [fasting plasma glucose (mg/dl) × fasting triglyceride level (mg/dl)/2]. Diabetes was defined as fasting plasma glucose ≥7.0 mmol/L and/or self-reported diabetes. Cox proportion-hazard model was employed to evaluate the independent impact of baseline TyG index on future diabetes risk. Sensitivity and subgroup analyses were implemented to verify the reliability of results. Notably, data were downloaded from the DATADRYAD website, and used only for secondary analyses.Results: During an average follow-up of 3.12 years, among 201,298 individuals aged ≥20 years, 3,389 subjects developed diabetes. After adjusting for potential confounders, elevated TyG index were independently correlated with greater risk of incident diabetes (hazard ratio (HR), 3.34; 95% confidence interval (CI), 3.11–3.60). Compared with the lowest quartile (Q1), increasing TyG index (Q2, Q3, and Q4) was related to increased HR estimates of incident diabetes [HR (95% CI), 1.83 (1.49–2.26); 3.29 ( 2.70–4.01), and 6.26 (5.15–7.6), respectively]. Moreover, a nonlinear relationship was observed between TyG index and risk of diabetes and the slope of the curve increased accompanying the rise of TyG index. Subgroup analysis revealed the positive association was stronger among subjects with age< 40 years, body mass index ≥18.5 kg/m2 and < 24 kg/m2, or systolic blood pressure <140 mmHg, or in females.Conclusions: Elevated TyG index is independently correlated with increased risk of incident diabetes in Chinese adults, indicating it may represent a reliable predictor of diabetes in high-risk populations.

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The incidence rate of diabetes mellitus (type II) and its related risk factors: A 10-year longitudinal study of Yazd Healthy Heart Cohort (YHHC), Iran

Cited by 17 publications

References 12 publications

Association between exposure to ambient fine particulate matter and prevalence of type 2 diabetes in Iran: an ecological study

Association between exposure to ambient fine particulate matter and prevalence of type 2 diabetes in Iran: an ecological study

Association between triglyceride-glucose index and risk of incident diabetes: a secondary analysis based on a Chinese cohort study

Association Between Triglyceride-Glucose Index and Risk of Incident Diabetes: A Secondary Analysis Based on A Chinese Cohort Study

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