The Inconclusive Results of the Studies on Glycoprotein IIIa Platelet Receptor Gene Polymorphism and Coronary Artery Disease

The Inconclusive Results of the Studies on Glycoprotein IIIa Platelet Receptor Gene Polymorphism and Coronary Artery Disease

“…Finally, contrasting with the statement by Koza and Senocak, 1 we do not think that the treatment of a coronary lesion, either by percutaneous coronary intervention or surgery, can be equalized with a normal coronary artery. In fact, those patients already developed significant coronary atherosclerosis and therefore cannot be considered healthy patients.…”

“…Moreover, we previously reported that the carriers of the mutated allele did not display an increased platelet baseline reactivity or a different response to direct GP IIb/IIIa antagonists, among 80 patients undergoing percutaneous coronary intervention (PCI). 17 Finally, contrasting with the statement by Koza and Senocak, 1 we do not think that the treatment of a coronary lesion, either by percutaneous coronary intervention or surgery, can be equalized with a normal coronary artery. In fact, those patients already developed significant coronary atherosclerosis and therefore cannot be considered healthy patients.…”

“…Monica Verdoia, MD 1 and Giuseppe De Luca, MD, PhD 1,2 ; on behalf of the Novara Atherosclerosis Study Group (NAS)…”

“…We thank Dr Koza 1 for his interest in our article entitled “Relationship between glycoprotein IIIa platelet receptor gene polymorphism and coronary artery disease,” 2 addressing the relationship between platelet glycoprotein (GP) IIb/IIIa polymorphism and the prevalence and extent of coronary artery disease (CAD).…”

“…We disagree with some considerations of Koza and Senocak. 1 First, our population represents a consecutive cohort of patients, and Dr Koza will certainly agree that in public hospitals around the world, acute coronary syndrome (ACS) represents the most common indication for coronary angiography. We understand his point of view concerning the potential mechanisms of ACS; however, he will agree that nowadays the vast majority of patients with ACS undergo angioplasty or surgery, due to the presence of significant coronary stenosis.…”