The incorporation of strontium and zinc into a calcium–silicon ceramic for bone tissue engineering

Zreiqat, Hala; Ramaswamy, Yogambha; Wu, Chengtie; Paschalidis, Angelo; Lu, Zufu; James, B. W.; Birke, Oliver; McDonald, Michelle M.; Little, David; Dunstan, Colin R.

doi:10.1016/j.biomaterials.2010.01.024

Cited by 270 publications

(185 citation statements)

References 33 publications

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“…Previous reports have shown that Sr-loaded biomaterial scaffolds exhibited increase resorption/dissolution comparing with uncoated ones [21,22]. For instance, a calcium-silicon ceramic [22] and a mesoporous bioactive glass scaffold [21] were more readily resorbed when loaded with Sr.…”

Section: Discussionmentioning

confidence: 97%

“…Systemic administration of Sr (in the form of Sr ranelate-SrR) has been shown to improve bone quality and reduces the risk of fractures both in females with postmenopausal osteoporosis and osteoporotic men [17,18]. More recently, several experimental studies have shown promising results in terms of increased bone formation after Sr enrichment of various bone substitute materials, such as allogeneic bone [19], bioactive bioglass [20,21], calciumsilicon ceramic [22], calcium phosphate [23,24], and hydroxyapatite [25,26]. Furthermore, it was observed in recent experiments that Sr-loaded titanium implants presented significantly increased bone-to-implant contact, comparing to control implants [27][28][29].…”

Section: Introductionmentioning

confidence: 98%

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Loading deproteinized bovine bone with strontium enhances bone regeneration in rat calvarial critical size defects

et al. 2018

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Objective To evaluate the effect of grafting with strontium (Sr)-loaded deproteinized bovine bone (DBB) on bone healing in calvarial critical size defects (CSD) in rats. Material and methods Two circular bone defects (5 mm in diameter) were created in the calvaria of 42 rats. One of the defects, randomly chosen, was grafted with (a) DBB, (b) DBB loaded with 19.6 μg/g of Sr (DBB/Sr1), or (c) DBB loaded with 98.1 μg/g of Sr (DBB/Sr2). The other defect was left empty as negative control. Groups of seven animals from each of the groups were euthanized 15 and 60 days post-op. Bone healing in the CSD was evaluated by micro-CT and histology/histomorphometry and immunohistochemistry.Results DBB/Sr2-grafted sites showed statistically significantly shorter radiographic residual defect length compared with DBB/ Sr1-and DBB-grafted sites, and with empty controls at 60 days. Further, the amount of new bone formation in the DBB/Sr1-and DBB/Sr2-grafted sites was significantly higher compared with that in the DBB-grafted sites at 60 days. A larger number of DBB/ Sr1-and DBB/Sr2-grafted sites presented with no-or only limited to mild inflammation, compared with the DBB-grafted sites, especially at 60 days. Higher expression of osteocalcin was observed in DBB/Sr1-and DBB/Sr2-grafted sites as compared to DBB-grafted sites. Conclusion Grafting with Sr-loaded DBB enhanced bone formation in CSD in rats, when compared with grafting with nonloaded DBB. Clinical relevance Grafting with Sr-loaded DBB may enhance bone formation in bone defects.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

Loading deproteinized bovine bone with strontium enhances bone regeneration in rat calvarial critical size defects

et al. 2018

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“…In response to the beneficial effects of Sr 2+ ion release, a variety of strategies have been proposed including the incorporation of Sr 2+ into ceramic coatings, bioactive glasses, etc [6,55,56]. The advantage of incorporating Sr 2+ ions into the bulk of Mg alloy, such as the J1 alloy, resides in the stable and continued ion release (Figs.…”

Section: Discussionmentioning

confidence: 99%

“…Sr increases osteoblast replication, differentiation, and bone matrix mineralization relying on calcium sensing receptor dependent mechanism [3][4][5]. Previous studies incorporated Sr into calcium phosphate coatings or bioactive glasses to stimulate the bone formation [6][7][8][9]. Nonetheless, long-lasting Sr release at a reasonably constant rate is hardly achieved in these cases due to low and unstable solubility of Sr in calcium phosphates and glasses [10,11].…”

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confidence: 98%

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

et al. 2016

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An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg-1Sr alloyIn: Acta Biomaterialia (2015) Elsevier DOI: 10.1016DOI: 10. /j.actbio.2015 An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg-1Sr alloy AbstractPrevious studies indicated that local delivery of strontium effectively increased bone quality and formation around osseointegrating implants. Therefore, implant materials with long-lasting and controllable strontium release are avidly pursued. The central objective of the present study was to investigate the in vivo biocompatibility, metabolism and osteogenic activity of the bioabsorbable Mg-1Sr (wt.%, nominal composition) alloy for bone regeneration. The general corrosion rate of the alloy implant as a femoral fracture fixation device was 0.55 ± 0.03 mm y −1 (mean value ± standard deviation) in New Zealand White rabbits which meet the bone implantation requirements and can be adjusted by material processing methods. All rabbits survived and the histological evaluation showed no abnormal physiology or diseases 16 weeks post-implantation. The degradation process of the alloy did not significantly alter 16 primary indexes of hematology, cardiac damage, inflammation, hepatic functions and metabolic process. Significant increases in peri-implant bone volume and direct bone-toimplant contact (48.3% ± 15.3% and 15.9% ± 5.6%, respectively) as well as the expressions of four osteogenesis related genes (runt-related transcription factor 2, alkaline phosphatase, osteocalcin, and collagen, type I, alpha 1) were observed after 16 weeks implantation for the Mg-1Sr group when compared to the pure Mg group. The sound osteogenic properties of the Mg-1Sr alloy by longlasting and controllable Sr release suggesting a very attractive clinical potential. Statement of significanceSr (strontium) has exhibited pronounced effects to reduce the bone fracture risk in osteoporotic patients. Nonetheless, long-lasting local Sr release is hardly achieved by traditional methods like surface treatment. Therefore, a more efficient Sr local delivery platform is in high clinical demand. The stable and adjustable degradation process of Mg alloy makes it an ideal Sr delivery platform. We combine the well-known osteogenic properties of strontium with magnesium to manufacture bioabsorbable Mg-1Sr alloy with stable Sr release based on our previous studies. The in vitro and in vivo results both showed the alloy's suitable degradation rate and biocompatibility, and the sound osteogenic properties and stimulation effect on bone formation suggest its very attractive clinical potential.

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“…18,20,27 Thus, constant in situ release of Sr at a proper dose directly at the implant-tissue interface has been proposed to enhance the implant osseointegration, and multiple recent studies have investigated the benefits of Sr loading onto biomaterials. 21,[28][29][30][31] On the basis of the hypothesis that the combination of an appropriate NT-coated surface and controllable, long-term Sr release may give rise to a material with an enhanced ability to promote osteogenesis and thus achieve rigid implant osseointegration, we developed a series of NT-coated, Sr-loaded Ti samples and found that the NT-Sr structure with suitable Sr loading led to improved proliferation, spreading, and osteogenic differentiation of in vitro cultured MSCs. 32 Although our in vitro results were promising, in vivo observations are necessary to draw a final conclusion on the osseointegration ability of a biomaterial.…”

Section: Introductionmentioning

confidence: 99%

In vivo osseointegration of Ti implants with a strontium-containing nanotubular coating

Yong-gang¹,

Zhang²,

Song³

et al. 2016

IJN

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Novel biomedical titanium (Ti) implants with high osteogenic ability for fast and good osseointegration under normal as well as osteoporotic conditions are urgently needed. Expanding on our previous in vitro results, we hypothesized that nanotubular, strontium-loaded (NT-Sr) structures on Ti implants would have favorable osteogenic effects and evaluated the in vivo osseointegration of these implants in rats. The structures with nanotubes of different diameters were fabricated by electrochemical anodization at 10 and 40 V, and the amounts of Sr loaded were adjusted by using two hydrothermal treatment times of 1 and 3 hours. Qualitative microcomputed tomography in two and three dimensions showed that the NT-Sr formed with an anodization voltage of 10 V and hydrothermal treatment time of 3 hours best supported bone growth in vivo. Histomorphometric examination of osseointegration also showed that more newly formed bone was found at its surface. The bone–implant contact percentage was highest (92.48%±0.76%) at 12 weeks. In conclusion, the NT-Sr formed with an anodization voltage of 10 V and hydrothermal treatment time of 3 hours showed excellent osteogenic properties, making it an attractive option for Ti surface modification with considerable clinical potential.

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The incorporation of strontium and zinc into a calcium–silicon ceramic for bone tissue engineering

Cited by 270 publications

References 33 publications

Loading deproteinized bovine bone with strontium enhances bone regeneration in rat calvarial critical size defects

Loading deproteinized bovine bone with strontium enhances bone regeneration in rat calvarial critical size defects

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

In vivo osseointegration of Ti implants with a strontium-containing nanotubular coating

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