The increase in P-wave dispersion is associated with the duration of disease in patients with Behçet's disease

Dogan, Sait Mesut; Aydın, Mustafa; Gürsürer, Metin; Yıldırım, Nesligül; Tekin, Nilgün Solak; Altınyazar, Cevdet; Onuk, Tolga; Sayın, Raşit

doi:10.1016/j.ijcard.2006.12.087

Cited by 19 publications

(16 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the study by Dilaveris et al 30, the sensitivity and specificity for P-wave dispersion in paroxysmal idiopathic atrial fibrillation was found to be 83% and 85%, respectively. In a study by Dogan et al 31, on Behçet's disease and on rheumatoid arthritis by Guler et al 32 and Yavuzkır et al 33, increase in maximum P-wave duration and P-wave dispersion were reported. In this study, the mean values of the patient and control group were, Pmax: 102.75±22.10 vs 97.89±13.59, Pmin: 56.95±20.88 vs 59.73±15.15 and P-wave dispersion: 45.50±16.98 vs 38.15±14.86, respectively.…”

Section: Discussionmentioning

confidence: 95%

Evaluation of QT and P Wave Dispersion and Mean Platelet Volume among Inflammatory Bowel Disease Patients

Doğan¹,

Soylu²,

Eren³

et al. 2011

Int. J. Med. Sci.

View full text Add to dashboard Cite

Background: In inflammatory bowel disease (IBD) number of thromboembolic events are increased due to hypercoagulupathy and platelet activation. Increases in mean platelet volume (MPV) can lead to platelet activation, this leads to thromboembolic events and can cause acute coronary syndromes. In IBD patients, QT-dispersion and P-wave dispersion are predictors of ventricular arrhythmias and atrial fibrilation; MPV is accepted as a risk factor for acute coronary syndromes, we aimed at evaluating the correlations of these with the duration of disease, its localization and activity.Methods: The study group consisted of 69 IBD (Ulcerative colitis n: 54, Crohn's Disease n:15) patients and the control group included 38 healthy individuals. Disease activity was evaluated both endoscopically and clinically. Patients with existing cardiac conditions, those using QT prolonging medications and having systemic diseases, anemia and electrolyte imbalances were excluded from the study. QT-dispersion, P-wave dispersion and MPV values of both groups were compared with disease activity, its localization, duration of disease and the antibiotics used.Results: The P-wave dispersion values of the study group were significantly higher than those of the control group. Duration of the disease was not associated with QT-dispersion, and MPV levels. QT-dispersion, P-wave dispersion, MPV and platelet count levels were similar between the active and in mild ulcerative colitis patients. QT-dispersion levels were similar between IBD patients and the control group. No difference was observed between P-wave dispersion, QT-dispersion and MPV values; with regards to disease duration, disease activity, and localization in the study group (p>0.05).Conclusions: P-wave dispersion which is accepted as a risk factor for the development of atrial fibirilation was found to be high in our IBD patients. This demonstrates us that the risk of developing atrial fibrillation may be high in patients with IBD. No significant difference was found in the QT-dispersion, and in the MPV values when compared to the control group.

show abstract

Section: Discussionmentioning

confidence: 95%

Evaluation of QT and P Wave Dispersion and Mean Platelet Volume among Inflammatory Bowel Disease Patients

Doğan¹,

Soylu²,

Eren³

et al. 2011

Int. J. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…Therefore, it has been suggested that PD can be used in the diagnosis of patients with a high risk of AF 7,8. It was moreover shown that PD was prolonged in chronic, inflammatory and rheumatic diseases, such as rheumatoid arthritis and Behcet’s disease 29,30…”

Section: Discussionmentioning

confidence: 99%

Atrial electromechanical coupling intervals in pregnant subjects : cardiovascular topic

Altun¹,

Taşolar²,

Gazı³

et al. 2014

CVJA

View full text Add to dashboard Cite

SummaryObjectiveThe aim of this study was to evaluate atrial conduction abnormalities obtained by tissue Doppler imaging (TDI) and electrocardiogram analysis in pregnant subjects.MethodsA total of 30 pregnant subjects (28 ± 4 years) and 30 controls (28 ± 3 years) were included. Systolic and diastolic left ventricular (LV) function was measured using conventional echocardiography and TDI. Inter-atrial, intra-atrial and intra-left atrial electromechanical coupling (PA) intervals were measured with TDI. P-wave dispersion (PD) was calculated from a 12-lead electrocardiogram.ResultsAtrial electromechanical coupling at the septal and left lateral mitral annulus (PA septal, PA lateral) was significantly prolonged in pregnant subjects (62.1 ± 2.7 vs 55.3 ± 3.2 ms, p < 0.001; 45.7 ± 2.5 vs 43.1 ± 2.7 ms, p < 0.001, respectively). Inter-atrial (PA lateral – PA tricuspid), intra-atrial (PA septum – PA tricuspid) and intra-left atrial (PA lateral – PA septum) electromechanical coupling intervals, maximum P-wave (Pmax) duration and PD were significantly longer in the pregnant subjects (26.4 ± 4.0 vs 20.2 ± 3.6 ms, p < 0.001; 10.0 ± 2.0 vs 8.0 ± 2.6 ms, p = 0.002; 16.4 ± 3.3 vs 12.2 ± 3.0 ms, p < 0.001; 103.1 ± 5.4 vs 96.8 ± 7.4 ms, p < 0.001; 50.7 ± 6.8 vs 41.6 ± 5.5 ms, p < 0.001, respectively). We found a significant positive correlation between inter-atrial and intra-left atrial electromechanical coupling intervals and Pmax (r = 0.282, p = 0.029, r = 0.378, p = 0.003, respectively).ConclusionThis study showed that atrial electromechanical coupling intervals and PD, which are predictors of AF, were longer in pregnant subjects and this may cause an increased risk of AF in pregnancy.

show abstract

“…Cardiac involvement can manifest with apparent symptoms or can be subclinical. In recent studies, P wave abnormalities have been demonstrated in patients with BD (9,10,18 Data are expressed as mean±standard deviation and median (minimum-maximum). BMI -body mass index, DBP-diastolic blood pressure, LVDd -left ventricular diastolic diameter, LVEF -left ventricular ejection fraction, LVM-left ventricular mass; LVMI -left ventricular mass index, LVSd -left ventricular systolic diameter, msec-millisecond; mm-millimeters, Pmax -maximum P wave duration, Pmin -minimum P wave duration, PD -P wave dispersion, SBP -systolic blood pressure of tachyarrhythmia encountered in clinical practice and is associated with increased morbidity and mortality (19).…”

Section: Discussionmentioning

confidence: 99%

“…Prolonged P wave duration and PD have been reported to represent an increased risk for atrial fibrillation (AF), and are also related with stable angina pectoris, acute coronary syndromes, coronary slow flow phenomenon, hypertrophic cardiomyopathy (6)(7)(8). Increased P wave duration and PD have been reported in patients with BD (9,10).…”

Section: Introductionmentioning

confidence: 99%

The effect of nebivolol on P wave duration and dispersion in patients with Behçet’s disease; a prospective single-arm controlled study

Akkaya¹,

Karakaş²,

Şahin³

et al. 2013

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

Objective: Behçet's disease (BD) is a chronic multi-system disease presenting with recurrent oral and genital ulceration, and relapsing uveitis. Left ventricular diastolic dysfunction, ventricular arrhythmia and sudden cardiac death have been documented in BD. P wave dispersion (PD) has been reported to be associated with inhomogeneous and discontinuous propagation of sinus impulses. PD has been reported to be longer in patients with BD. Nebivolol, besides its selective beta1-blocking activity, causes an endothelium dependent vasodilatation through nitric oxide release. In this study, we searched for the effects of nebivolol on P wave duration and dispersion in patients with BD. Methods: This study was designed as prospective single-arm controlled study. We prospectively studied 35 Behçet's patients who were diagnosed according to the International Study Group criteria. Patients received 5 mg nebivolol per day for 3 months. The patients were evaluated with 12-leads electrocardiography at baseline and after for 3-month therapy. The difference between maximum and minimum P wave durations was defined as PD. The paired samples t test, Wilcoxon test were used for statistical analysis. Results: A significant decrease was observed in PD after therapy period (62.85±21.62 vs. 44.28±18.03 msec, p=0.001). No adverse effects were observed in treatment period. Conclusion: BD is associated with prolonged P wave duration and dispersion. We have shown for the first time that nebivolol causes a significant decrease in maximum P wave duration and PD in patients with BD. However, further comprehensive studies are needed to determine the long-term effects of nebivolol. (Anadolu Kardiyol Derg 2013; 13: 682-7) Key words: Behçet's disease, nebivolol, P wave dispersion Original Investigation Özgün Araşt›rma 682ÖZET Amaç: Behçet hastalığı (BH), tekrarlayıcı oral ve genital ülserasyon ve üveit atakları ile karakterize, kronik multisistemik bir hastalıktır. BH'da sol ventrikül diyastolik disfonksiyonu, ventriküler aritmi ve ani kardiyak ölüm vakaları bildirilmiştir. P dalga dispersiyonu (PD)'nun, sinüs uyarılarının homojen olmayan ve kesintili yayılımı ile ilişkili olduğu gösterilmiştir. PD'nin BH'da daha uzun olduğu gösterilmiştir. Selektif beta 1 bloker olan nebivolol, nitrik oksit salınımı sayesinde endotel bağımlı vazodilatasyon yapar. Bu çalışmada, BH'da nebivololün P dalga süresi ve PD üzerinde-ki etkisini araştırdık. Yöntemler: Bu araştırma prospektif, tek grup kontrollü çalışma olarak tasarlandı. Çalışmaya Uluslararası Çalışma Grubu kriterlerine uyan 35 BH alındı. Hastalara 3 ay süreyle 5 mg/gün nebivolol verildi. Hastalar başlangıçta ve 3 aylık tedavi sonrasında 12 kanallı elektrokardiyografi ile değerlendirildi. Maksimum ve minimum P dalga süresi arasındaki fark PD olarak belirlendi. Paired samples t-test, Wilcoxon testi istatistiksel değerlendirme için kullanıldı. Bulgular: Tedavi sonrasında PD'da belirgin azalma izlendi (62.85±21.62'e karşı 44.28±18.03 msn, p=0.001). Tedavi süresinde herhangi bir yan etki izlenmedi. So...

show abstract

The increase in P-wave dispersion is associated with the duration of disease in patients with Behçet's disease

Cited by 19 publications

References 16 publications

Evaluation of QT and P Wave Dispersion and Mean Platelet Volume among Inflammatory Bowel Disease Patients

Evaluation of QT and P Wave Dispersion and Mean Platelet Volume among Inflammatory Bowel Disease Patients

Atrial electromechanical coupling intervals in pregnant subjects : cardiovascular topic

The effect of nebivolol on P wave duration and dispersion in patients with Behçet’s disease; a prospective single-arm controlled study

Contact Info

Product

Resources

About