The India Mutations and B.1.617 Delta Variants: Is There a Global "Strategy" for Mutations and Evolution of Variants of the Sars-Cov2 Genome?

Pérez, José María Hernández

doi:10.29121/granthaalayah.v9.i6.2021.4039

Cited by 3 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, this Prion regio n TOTALLY disappears from the new OMICRON 21K (SA1) and 21L (Minesota) variants. It is mathematically demonstrated that a hidden fractal order exists in DNA and RNA genomic sequences Perez (1991), , Perez (2021a), Perez (2021b) . It consists of long-range Fibonacci meta-structures that are being thought to be associated with genome overall stability in relation with their conformational structure and dynamic.…”

Section: International Journal Of Research -Granthaalayahmentioning

confidence: 99%

“…In two articles published in 2021 Perez (2021a) and Perez (2021b) , we showed how the FIBONACCI fractal analysis method makes it possible to measure the progressive adaptation of successive variant genomes to the human host. Thus, we demonstrated how at the double levels of the spike and of the whole genome, Fibonacci meta-structures in UA / CG proportions of covering the entire genome sequence were permanently reinforced between the original Wuhan strain then the 3 successive worldwide variants D614G, ALPHA, and DELTA.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Omicron Variant Breaks the Evolutionary Lineage of Sars-Cov2 Variants

Pérez¹,

Lounnas

Montagnier³

2021

Int. J. Res. Granthaalayah

Self Cite

View full text Add to dashboard Cite

We analyze here 7 very first strains of OMICRON the SARS-CoV2 new variant from South Africa, the USA (California and Minesota), Canada and Belgium. We applied, at the scale of the whole genome and the spike gene, the biomathematics method of Fibonacci meta-structure fractal analysis applied to the UA / CG proportions. We have evidenced the RUPTURE of OMICRON with respect to ALL the previous variants: D614G, ALPHA, BETA, GAMMA, DELTA. Remarkably, it is observed that the density of OMICRON mutations in the SPIKE PRION region is more than 8 times that of the rest of the Spike protein. In particular, we suggest that the mRNA stabilizing secondary structure ("hairpin" conformation) in the spike of all variants is degraded in OMICRON, probably making its mRNA more fragile. The loss of long-range fractal meta-structures in the OMICRON spike gene are in line with common knowledge on the mechanisms of epidemic ending, involving recombination of heavily mutated RNA fragments of the virus, with the possible inference of a distinct helper virus. This would indicate that the SARS-CoV2 is under very strong evolutionary pressure, possibly marking the end of the pandemic. We are studying more particularly the prion-like region of the spike, the mutations rate of which is 8 times higher in OMICRON than that of the whole spike protein.

show abstract

Section: International Journal Of Research -Granthaalayahmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Omicron Variant Breaks the Evolutionary Lineage of Sars-Cov2 Variants

Pérez¹,

Lounnas

Montagnier³

2021

Int. J. Res. Granthaalayah

Self Cite

View full text Add to dashboard Cite

show abstract

Peculiar evolution of the Monkeypox virus genomes

Pérez¹

2022

IJVV

View full text Add to dashboard Cite

We compare the evolution of 14 genomes of monkeypox viruses including that of May 2022 that is currently spreading among humans in numerous countries outside Africa. Our aim was to discover mutations and other viral evolutions (recombination) of the virus genome that may explain the sudden impact of this epidemic circulating at very low-level and alert on its potential pathogenic character. We have evidenced the presence of a succession of a large number of T bases between the DNA-dependent RNA polymerase subunit rpo132 and the cowpox A-type inclusion protein, progressively rising from the absence of a characteristically long pattern of T-bases found in succession (≤ 10) in the early genomes of 1971, up to the 19 T-base sequence in the Israel 2018 reference strain and the 30 T bases thereafter in the 2022 strains. We find a complementary match for this long sequence of T bases only in the simian hemorrhagic encephalitis virus, at the 3’ end of the genome with a long succession of 28 A-bases after the stop codon. More strikingly, we find that the corresponding 10 phenyl-alanine aa chain is reported as matching uniquely (E≤0.001) a hypothetical protein element in Plasmodium falciparum, Yersinia pestis, Escherichia coli and Penicillium nordicum. We wonder whether this region of the monkeypox genome situated right upstream this long T-repeat may potentially code for a not yet identified polypeptide sequences with a functional role.

show abstract

Six Fractal Codes of Life From Bioatoms Atomic Mass to Chromosomes Numerical Standing Waves: Three Breakthoughs in Astrobiology, Cancers and Artificial Intelligence

Pérez¹,

Montagnier²

2021

Int. J. Res. Granthaalayah

Self Cite

View full text Add to dashboard Cite

The discovery of a simple numerical formula for the projection of all the atomic mass of life-sustaining CONHSP bioatoms leads to the emergence of a set of Nested CODES unifying all the biological, genetic and genomic components by unifying them from bioatoms up to 'to whole genomes. In particular, we demonstrate the existence of a digital meta-code common to the three languages of biology that are RNA, DNA and amino acid sequences. Through this meta-code, genomic and proteomic images appear almost analogous and correlated. The analysis of the textures of these images then reveals a binary code as well as an undulatory code whose analysis on the human genome makes it possible to predict the alternating bands constituting the cariotypes of the chromosomes. The application of these codes to perspectives in astrobiology and the emergence of binary codes and regions of local stability (voting process), whose fractal nature we demonstrate, is illustrated. The fundamental discovery described here will undoubtedly one day constitute a new biomathematic approach to the emergence of living things.

show abstract

The India Mutations and B.1.617 Delta Variants: Is There a Global "Strategy" for Mutations and Evolution of Variants of the Sars-Cov2 Genome?

Cited by 3 publications

References 24 publications

The Omicron Variant Breaks the Evolutionary Lineage of Sars-Cov2 Variants

The Omicron Variant Breaks the Evolutionary Lineage of Sars-Cov2 Variants

Peculiar evolution of the Monkeypox virus genomes

Six Fractal Codes of Life From Bioatoms Atomic Mass to Chromosomes Numerical Standing Waves: Three Breakthoughs in Astrobiology, Cancers and Artificial Intelligence

Contact Info

Product

Resources

About