The induction of ornithine decarboxylase activity and its control in mouse skin epidermis

Boutwell, R. K.; O'Brien, T. G.; Verma, Ajit Kumar; Weekes, Richard G.; DeYoung, L.M.; Ashendel, Curtis L.; Astrup, Erle Grieg

doi:10.1016/0065-2571(79)90009-8

Cited by 20 publications

(6 citation statements)

References 26 publications

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“…metabolism might play a role in tumor development (Boutwell et al, 1979;Ferioli, 1981, 1982;Verma and Boutwell, 1987), led to a search for agents which could effectively deplete intracellular polyamines.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Metabolism and action of amino acid analog anti-cancer agents

Ahluwalia

Grem

Zhang

et al. 1990

Pharmacology & Therapeutics

220

173

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Abstract--The preclinical pharmacology, antitumor activity and toxicity of seven of the more important amino acid analogs, with antineoplastic activity, is discussed in this review. Three of these compounds are antagonists of L-glutamine: acivicin, DON and azaserine; and two are analogs of L-aspartic acid: PALA and L-alanosine. All five of these antimetabolites interrupt cellular nucleotide synthesis and thereby halt the formation of DNA and/or RNA in the tumor cell. The remaining two compounds, buthionine sulfoximine and difluoromethylornithine, are inhibitors of glutathione and polyamine synthesis, respectively, with limited intrinsic antitumor activity; however, because of their powerful biochemical actions and their low systemic toxicities, they are being evaluated as chemotherapeutic adjuncts to or modulators of other more toxic antineoplastic agents. CONTENTS

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Section: Mechanism Of Actionmentioning

confidence: 99%

Metabolism and action of amino acid analog anti-cancer agents

Ahluwalia

Grem

Zhang

et al. 1990

Pharmacology & Therapeutics

220

173

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“…Four of the seven desmoid tumor patients have been described in some detail elsewhere [ 1,321. Patients 4,5 ,and 6 in Table I and Appendix had Gardners syndrome. One patient had desmoid tumor in the mediastinum and sternum, and another had subclavicular chest wall tumor.…”

Section: Desmoid Tumorsmentioning

confidence: 99%

Nonsteroid antiinflammatory drugs and tamoxifen for desmoid tumors and carcinoma of the stomach

Waddell

Cerner

Reich

1983

Journal of Surgical Oncology

146

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The results of treatment of desmoid tumor patients with nonsteroid antiinflammatory drugs alone or in combination with tamoxifen are described. Tumor growth was inhibited in six of seven patients. Nonsteroid antiinflammatory drugs administered along with 5-fluorouracil and cyclophosphamide and other inhibitors of T-suppressor cells were used to treat nine patients with metastatic carcinoma of the stomach. Survival of these patients was extended so that after 12 months minimal follow-up the majority are well. A prospective controlled clinical trial is indicated.

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“…(i) Hyperplastic transformation is accompanied by distinct and characteristic biochemical processes such as a pronounced induction of ornithine decarboxylase activity, i.e. stimulation of polyamine formation in epidermis (O'Brien, 1976;Boutwell et al, 1979;Marks, Bertsch & Fiirstenberger, 1979), and a desensitization of (mouse) epidermis to hormones such as adrenalin and prostaglandin E which stimulate adenylate cyclase activity (Marks et al,I98ia,b and unpublished results) as well as to an antiproliferative tissue hormone, the epidermal Gi-chalone (summarized by Marks et al, 1978). Moreover, agents which induce hyperplastic transforma-18 tion of skin have been shown to impair metabolic cooperation in tissue culture (Fitzgerald & Murray, 1980;Trosko et al, 1982).…”

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confidence: 99%

Hyperplastic transformation: the response of mouse skin to irritation

Marks

Fürstenberger

Ganss

et al. 2006

British Journal of Dermatology

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Vertebrate skin fulfils its protective function mainly in two different ways: (1) the epithelium forms an extremely resistant layer of horny structures (scales, hair, etc.) which are permanently replaced by means of cellular proliferation and maturation; (2) skin has a remarkable ability to respond quickly to all kinds at attack from the environment by an acceleration of cellular proliferation in the epidermis (which leads to a closure of wounds or a thickening of the protective layer) and by a stimulation of other defense mechanisms such as the recruitment of white blood cells as a constituent of inflammatory reactions.

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The induction of ornithine decarboxylase activity and its control in mouse skin epidermis

Cited by 20 publications

References 26 publications

Metabolism and action of amino acid analog anti-cancer agents

Metabolism and action of amino acid analog anti-cancer agents

Nonsteroid antiinflammatory drugs and tamoxifen for desmoid tumors and carcinoma of the stomach

Hyperplastic transformation: the response of mouse skin to irritation

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