The Inferior Colliculus: A Hub for the Central Auditory System

Casseday, John H.; Fremouw, Thane; Covey, Ellen

doi:10.1007/978-1-4757-3654-0_7

Cited by 146 publications

(165 citation statements)

References 253 publications

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“…At least based on animal studies, we believe that stimulation of more rostral and ventrolateral regions within the ICC may provide additional improvements in performance (Lim and Anderson, 2007), and this may be sufficient to restore open-set speech perception. However, if we are going to take advantage of the enormous amount of information passing through the IC, which receives almost all projections from lower brainstem nuclei (Casseday et al, 2002), and considering that we observed different perceptual effects depending on stimulation location as discussed above, then we will likely need to develop a threedimensional array that sufficiently spans and activates the IC. These are questions we are currently investigating with the hope that the AMI will serve as a successful hearing alternative for those who cannot benefit from CIs.…”

Section: Sound Localizationmentioning

confidence: 99%

“…In particular, ICC stimulation achieves lower thresholds, greater dynamic ranges, and more localized, frequency-specific cortical activation than CI stimulation. The IC also receives inputs from almost all brainstem pathways projecting to higher perceptual centers (Casseday et al, 2002). Thus, it should provide direct access to a more complete set of pathways necessary for complex processing and binaural percepts than occurs in the cochlear nucleus or cochlea for the ABI or CI, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Electrical Stimulation of the Midbrain for Hearing Restoration: Insight into the Functional Organization of the Human Central Auditory System

Lim¹,

Lenarz²,

Joseph³

et al. 2007

J. Neurosci.

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The cochlear implant can restore speech perception in patients with sensorineural hearing loss. However, it is ineffective for those without an implantable cochlea or a functional auditory nerve. These patients can be implanted with the auditory brainstem implant (ABI), which stimulates the surface of the cochlear nucleus. Unfortunately, the ABI has achieved limited success in its main patient group [i.e., those with neurofibromatosis type 2 (NF2)] and requires a difficult surgical procedure. These limitations have motivated us to develop a new hearing prosthesis that stimulates the midbrain with a penetrating electrode array. We recently implanted three patients with the auditory midbrain implant (AMI), and it has proven to be safe with minimal movement over time. The AMI provides loudness, pitch, temporal, and directional cues, features that have shown to be important for speech perception and more complex sound processing. Thus far, all three patients obtain enhancements in lip reading capabilities and environmental awareness and some improvements in speech perception comparable with that of NF2 ABI patients. Considering that our midbrain target is more surgically exposable than the cochlear nucleus, this argues for the use of the AMI as an alternative to the ABI. Fortunately, we were able to stimulate different midbrain regions in our patients and investigate the functional organization of the human central auditory system. These findings provide some insight into how we may need to stimulate the midbrain to improve hearing performance with the AMI.

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Section: Sound Localizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrical Stimulation of the Midbrain for Hearing Restoration: Insight into the Functional Organization of the Human Central Auditory System

Lim¹,

Lenarz²,

Joseph³

et al. 2007

J. Neurosci.

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“…For the 10 msec tone, the EPSP occurs before the end of the IPSP and is rendered subthreshold by the sustained inhibition. Modified from Casseday et al (2002).…”

Section: Neurophysiologymentioning

confidence: 99%

Temporal Masking Reveals Properties of Sound-Evoked Inhibition in Duration-Tuned Neurons of the Inferior Colliculus

et al. 2003

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The inferior colliculus (IC) is the first place in the central auditory pathway where duration-selective neurons are found. Previous neuropharmacological and electrophysiological studies have shown that they are created there and have led to a conceptual model in which excitatory and inhibitory inputs are offset in time so that the cell fires only when sound duration is such that onset-and offsetevoked excitation coincide; the response is suppressed by inhibition at other durations. We tested predictions from the model using paired tone stimulation and extracellular recording in the IC of the big brown bat, Eptesicus fuscus. Responses to a best duration (BD) tone were used as a probe to examine the strength and time course of inhibition activated by a nonexcitatory (NE) tone of the same frequency but differing in duration. As the relative time between the BD and NE tones was varied, the activity evoked by the BD tone was affected in ways comparable with backward, simultaneous, and forward masking. Responses to the BD tone were completely suppressed at short interstimulus intervals when the BD tone preceded the NE tone. Suppression was also seen when the stimuli temporally overlapped and summed and at intervals when the BD tone followed the NE tone. The results show that duration-selective neurons receive an onsetevoked, inhibitory input that precedes their excitatory input. The period of leading inhibition was correlated with BD and first spike latency. The results suggest how inhibition in the CNS could explain temporal masking phenomena, including backward masking.

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“…Interactions among excitatory and inhibitory inputs are especially important in the inferior colliculus (IC) because the IC is the common target of both excitatory and inhibitory projections from the majority of lower auditory nuclei, from the opposite IC via its commissure and from descending projections of the auditory cortex (Oliver and Huerta, 1992;Casseday et al, 2002). Consistent with the massive convergence, a host of new response properties are created in the IC.…”

Section: Introductionmentioning

confidence: 99%

Spectrotemporal Receptive Fields in the Inferior Colliculus Revealing Selectivity for Spectral Motion in Conspecific Vocalizations

Andoni¹,

Li²,

Pollak³

2007

J. Neurosci.

165

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The Inferior Colliculus: A Hub for the Central Auditory System

Cited by 146 publications

References 253 publications

Electrical Stimulation of the Midbrain for Hearing Restoration: Insight into the Functional Organization of the Human Central Auditory System

Electrical Stimulation of the Midbrain for Hearing Restoration: Insight into the Functional Organization of the Human Central Auditory System

Temporal Masking Reveals Properties of Sound-Evoked Inhibition in Duration-Tuned Neurons of the Inferior Colliculus

Spectrotemporal Receptive Fields in the Inferior Colliculus Revealing Selectivity for Spectral Motion in Conspecific Vocalizations

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