The inflammatory effect of infection with Hymenolepis diminuta via the increased expression and activity of COX-1 and COX-2 in the rat jejunum and colon

Kosik-Bogacka, Danuta; Baranowska-Bosiacka, Irena; Kolasa, Agnieszka; Łanocha-Arendarczyk, Natalia; Gutowska, Izabela; Korbecki, Jan; Namieta, H; Rotter, Iwona

doi:10.1016/j.exppara.2016.07.009

Cited by 12 publications

(10 citation statements)

References 43 publications

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“…The dependence between COX enzymes and TLR-4 in lung tissues during parasite infection is not clear, albeit Derda et al [ 45 ] found an increased level of expression of TLR2 as well as TLR4 mRNA in lungs during Acanthamoeba infection. Moreover, as was suggested by Kosik-Bogacka et al [ 21 ] the increased COX expression and activity in the rat colon and jejunum in intestinal Hymenolepis diminuta infection is probably caused by increased levels of free radicals and a weakening of the host’s antioxidant defense induced by the presence of the parasite [ 21 ]. In another study, the expression of COX-2 and production of PGE 2 increased in response to acute respiratory infection with a variety of bacterial organisms and viruses [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…RIPA buffer (pH 7.4) was used for lung sample homogenization using a previously described method [ 21 ]. To asses total protein concentrations we used Micro BCA Protein Assay Kits (Thermo Scientific, Rockford, IL, USA).…”

Section: Methodsmentioning

confidence: 99%

“…Similar to COX-1, COX-2 plays an important role in allergic lung inflammation and asthma [ 9 ]. COX-2 has been shown to be induced by parasitic infections, but the mechanism is not clear [ 21 ]. In opportunistic parasitic infection, a strong correlation has been observed between COX-2 expression and Cryptosporidium sp.…”

Section: Introductionmentioning

confidence: 99%

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Expression and Activity of COX-1 and COX-2 in Acanthamoeba sp.-Infected Lungs According to the Host Immunological Status

Łanocha-Arendarczyk

Baranowska-Bosiacka

Kot

et al. 2018

IJMS

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Little is known about the pathomechanism of pulmonary infections caused by Acanthamoeba sp. Therefore, the aim of this study was to determine whether Acanthamoeba sp. may affect the expression and activity of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), resulting in the altered levels of their main products, prostaglandins (PGE2) and thromboxane B2 (TXB2), in lungs of immunocompetent or immunosuppressed hosts. Acanthamoeba sp. induced a strong expression of COX-1 and COX-2 proteins in the lungs of immunocompetent mice, which, however, did not result in significant differences in the expression of PGE2 and TXB2. Our immunohistochemical analysis showed that immunosuppression induced by glucocorticoids in Acanthamoeba sp.-infected mice caused a decrease in COX-1 and COX-2 (not at the beginning of infection) in lung tissue. These results suggest that similar to COX-2, COX-1 is an important mediator of the pathophysiology in experimental pulmonary acanthamoebiasis. We suggest that the signaling pathways important for Acanthamoeba sp. induction of lung infection might interact with each other and depend on the host immune status.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Expression and Activity of COX-1 and COX-2 in Acanthamoeba sp.-Infected Lungs According to the Host Immunological Status

Łanocha-Arendarczyk

Baranowska-Bosiacka

Kot

et al. 2018

IJMS

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“…In the gastrointestinal tract, the presence of cyclooxygenase 1 (COX-1) is found in most cells contributing to the production of PG under physiological conditions, whereas the expression of cyclooxygenase 2 (COX-2) is described in inflammatory processes induced by LPS, growth factors, ROS, and cytokines [99]. COX-1 is involved in maintaining homeostasis under physiological conditions and in early inflammatory conditions, causing the production of TXs and PGs, while COX-2 in late inflammation stages induces PG production [100]. …”

Section: Rat Tapeworm Hymenolepis Diminuta Rudolphi 1819mentioning

confidence: 99%

“…They determined that the expression and activity of COX-1 and COX-2 was responsible for the synthesis of prostaglandins and thromboxane. The study showed an increase in COX activity and expression in rats infected with H. diminuta , which could be due to increased levels of free radicals and weakened defensive antioxidative mechanisms [100]. Also, Ahmad et al, (2015) [102] found that hymenolepidosis in rats causes increased expression of cyclooxygenase 2 in the gut.…”

Section: Rat Tapeworm Hymenolepis Diminuta Rudolphi 1819mentioning

confidence: 99%

Selected Molecular Mechanisms Involved in the Parasite–Host System Hymenolepis diminuta–Rattus norvegicus

Kapczuk

Kosik-Bogacka

Łanocha-Arendarczyk

et al. 2018

IJMS

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The rat tapeworm Hymenolepis diminuta is a parasite of the small intestine of rodents (mainly mice and rats), and accidentally humans. It is classified as a non-invasive tapeworm due to the lack of hooks on the tapeworm’s scolex, which could cause mechanical damage to host tissues. However, many studies have shown that metabolites secreted by H. diminuta interfere with the functioning of the host’s gastrointestinal tract, causing an increase in salivary secretion, suppression of gastric acid secretion, and an increase in the trypsin activity in the duodenum chyme. Our work presents the biochemical and molecular mechanisms of a parasite-host interaction, including the influence on ion transport and host intestinal microflora, morphology and biochemical parameters of blood, secretion of antioxidant enzymes, expression of Toll-like receptors, mechanisms of immune response, as well as the expression and activity of cyclooxygenases. We emphasize the interrelations between the parasite and the host at the cellular level resulting from the direct impact of the parasite as well as host defense reactions that lead to changes in the host’s tissues and organs.

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Gallic acid and Catechin induce morphological alterations on the zoonotic parasite Hymenolepis diminuta

Mondal¹,

Mandal²,

Saha³

et al. 2023

Parasitol Res

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The inflammatory effect of infection with Hymenolepis diminuta via the increased expression and activity of COX-1 and COX-2 in the rat jejunum and colon

Cited by 12 publications

References 43 publications

Expression and Activity of COX-1 and COX-2 in Acanthamoeba sp.-Infected Lungs According to the Host Immunological Status

Expression and Activity of COX-1 and COX-2 in Acanthamoeba sp.-Infected Lungs According to the Host Immunological Status

Selected Molecular Mechanisms Involved in the Parasite–Host System Hymenolepis diminuta–Rattus norvegicus

Gallic acid and Catechin induce morphological alterations on the zoonotic parasite Hymenolepis diminuta

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