The Influence of Advanced Age on Cancer Occurrence and Growth

Ershler, William B.

doi:10.1007/0-387-23962-6_4

Cited by 7 publications

(3 citation statements)

References 52 publications

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“…As a general rule, most tumors differ in terms of a growth pattern, doubling time, hormonal receptor status, DNA ploidy, angiogenesis, percentage of cells in S-phase, P53 expression and extracellular matrix proteins expression [13]. Senescent tissues in general may also provide a microenvironment that is less capable of supporting rapid tumor growth and handling the accumulation of byproducts of normal cell physiological activity.…”

Section: Carcinogenesis In the Elderlymentioning

confidence: 99%

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Cancer in older men: A gender-based review

Cepeda

Gammack

2006

The Aging Male

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Cancer is a common condition of the older male. Risk factors for developing a malignancy include genetic, environmental and life style features. Cancer epidemiology and prognosis differ depending on the age and gender of the population being studied. In the group of men older than 65 years, the most common malignant tumors are prostate, lung, colon and pancreatic cancer. Treatment options vary depending on the stage of the tumor when it is diagnosed, and the decision for therapeutic versus palliative interventions will depend upon the functional status, comorbidity and personal wishes of the patients.

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Section: Carcinogenesis In the Elderlymentioning

confidence: 99%

“…The ability of natural killer cells to destroy cancer cells before they can accumulate is reduced [13]. In individual cells, the main regulator of division is located at the telomere at the end of each chromosome.…”

Section: Carcinogenesis In the Elderlymentioning

confidence: 99%

Cancer in older men: A gender-based review

Cepeda

Gammack

2006

The Aging Male

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“…In addition, different conditions can as well lead to the development of cancer in the human body caused by the rate of DNA and RNA alterations, an unhealthy environment (radioactive materials and other substances) (5), inadequate nutrition, unhealthy cell environment (6). Persons are genetically susceptible to abnormalities (7), people over 80 years (8), a category of illnesses, and terminating in a lump (9,10). Although several types of cancer have been seen, it has increased by 29 percent among females worldwide compared to all other cancer diagnoses (11).…”

Section: Introductionmentioning

confidence: 99%

Modified D-Glucofuranose Computationally Screening for Inhibitor of Breast Cancer and Triple Breast Cancer: Chemical Descriptor, Molecular Docking, Molecular Dynamics and Qsar

Kumer

Chakma

Chandro

et al. 2022

J. Chil. Chem. Soc.

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Drug discovery and the process of new drug design have been formulated much easier in the past two decades by introducing, proliferation of combined physical, biochemical process from computing capabilities and computational approaches. Since the breast cancer is one of the life-threatening problems globally, no effective prescription is still now invented or not available in the market or medical treatment. Although the few number of drugs is just touched on the market, the remedy has consisted of severe side effects and low efficiency. Regarding that fact, the D-glucofuranose and its derivatives have been designed by the quantum calculation, molecular docking, ADMET and SAR analysis. For molecular docking, the cancer protease (3hb5) and triple-negative breast cancer protease (4pv5) are selected for study whereas the binding affinity of cancer protease (3hb5) is found at ranging from -6.20 to -10.40 kcal/mol, and it is slightly lower than triple-negative breast cancer protease (4pv5). Next, the molecular dynamic has performed to make the validation of docking complex. In our forthcoming study, it has shown that the 03, 05, and 08 compounds could be considered the potential drug comparison with standard drug. These three drugs completed all the criteria, including high binding energy, non-toxic, non-carcinogenic, and highly soluble in biological system.

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