The influence of age and other prognostic factors associated with survival of ovarian immature teratoma — A study of 1307 patients

Chan, John K.; Gardner, A.B.; Chan, J.K.; Guan, Andrew; Alshak, Mark N.; Kapp, Daniel S.

doi:10.1016/j.ygyno.2016.07.001

Cited by 18 publications

(17 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another limitation is caused by the vide variation in AFP levels at birth and the variability in its half-time within the first year of life [ 2 ]. Multiple publications where cases of immature teratoma are analyzed without taking AFP levels into consideration makes it more difficult to form a credible assessment of this indicator [ 14 , 30 , 31 ]. Only one girl in the immature teratoma group had AFP levels < 1000 ng/mL in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Different staging systems, histopathologic classification systems and risk stratification are important factors impeding development of an appropriate treatment protocol [ 2 , 12 ]. Additional factors include the lack of consistent terminology in the literature and analyzing pediatric and adult patients together [ 5 , 20 , 31 ]. International cooperation seems the only way to progress in the prospective knowledge of prognostic factors for these tumors.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ovarian teratoma in children: a plea for collaborative clinical study

Łuczak

Bagłaj

2018

J Ovarian Res

View full text Add to dashboard Cite

BackgroundAlthough teratomas are the most common histologic subtype of childhood ovarian germ cell tumors, their appropriate treatment in this age group still remains unclear. Paucity of research dedicated exclusively to both mature and immature teratomas of the ovary, contribute to decision making difficulties.Therefore, we decided to review retrospectively our experience in treatment of pediatric ovarian teratomas in order to assess the epidemiology, presenting features, and diagnostic as well as surgical management of these lesions.ResultsThe study comprised 58 patients. Fifty percent of patients were between 9 and 15 years old. Mature teratoma was diagnosed in 55(94.83%) patients, while 3(5.17%) patients presented with immature teratoma. Twenty eight (50.91%) girls with mature teratoma had laparotomy and 23 (41.82%) had laparoscopy performed as an initial operative approach. Ovarian tissue sparing technique (preservation of the ovarian tissue of the affected gonad) was applied in only 11.11% of patients operated in the first study period (years 1999–2003) and increased to 40.54% in the second half of our study (years 2004–2016). The extent of gonadal resection was not related with the size of the lesion. Bilateral lesions were noted in 8 patients with mature teratoma. All girls with immature teratoma were subjected to formal laparotomy. Two patients had stage III of the disease and one had stage IV. They underwent at least resection of the affected gonad. Adjuvant chemotherapy was given to all girls with immature teratoma after the surgery.ConclusionsUnder particular conditions ovarian-sparing surgery might be successfully applied in children with mature teratoma. Laparotomy is the treatment of choice in large masses, suspicious for malignancy and if surgical staging is required. High quality prospective multi-institutional studies are required in order to get an objective insight into biology and prognostic factors of teratomas in children.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ovarian teratoma in children: a plea for collaborative clinical study

Łuczak

Bagłaj

2018

J Ovarian Res

View full text Add to dashboard Cite

show abstract

“…A menudo se diagnostica en secciones de tejido teñidas con hematoxilina-eosina y su diferenciación con tumores de ovario epiteliales de bajo grado puede ser difícil. Los implantes peritoneales aparecen como pequeños nódulos blanquecinos y pueden contener tejido glial maduro o inmaduro y, por lo general, están más diferenciados que en el tumor primario (11) . La progresión de estos implantes puede ser la transformación a fibroblastos con eventual desaparición posterior, persistencia sin cambios morfológicos o transformación maligna (4) .…”

Section: Discussionunclassified

“…El buen pronóstico también se asocia cuando los implantes consisten completamente en tejido glial maduro, aunque la recurrencia es más frecuente y la supervivencia libre de recurrencia más corta. Algunos implantes pueden permanecer estables, o sufrir regresión fibrosa o a glioblastoma (11) . No obstante, es necesario realizar el seguimiento a largo plazo para establecer la posible transformación maligna, ya que existen casos que progresan a condiciones malignas hasta 7 años después de la cirugía, en especial aquellos implantes asociados a teratoma inmaduro de ovario o en aquellos casos que no se logra la estadificación quirúrgica completa, evaluación histológica de los implantes y tratamiento con quimioterapia (5,13) .…”

Section: Discussionunclassified

Gliomatosis peritoneal asociada a teratoma maduro de ovario

Torres-Cepeda

Rondón-Tapía

2020

Rev peru ginecol obstet.

View full text Add to dashboard Cite

Los teratomas de ovario son tumores compuestos por tejidos derivados de las tres líneas germinales embrionarias. La gliomatosis peritoneal es una afección poco frecuente caracterizada por implantes de tejido glial en el peritoneo comúnmente asociada con teratoma inmaduro de ovario, no así con teratomas maduros. El diagnóstico definitivo se realiza por histología. No existen pautas sobre cómo realizar el seguimiento de los pacientes con esta afección. El pronóstico es favorable. Sin embargo, los implantes pueden experimentar regresión fibrótica o excepcionalmente degenerar a glioblastoma. Si están presentes tejido glial inmaduro u otros componentes teratomatosos en el peritoneo o epiplón, el tratamiento será similar al del carcinoma metastásico de ovario. En pacientes con enfermedad peritoneal residual, es necesario un seguimiento a largo plazo, debido al riesgo de recurrencia y transformación maligna. Se presenta un caso de gliomatosis peritoneal asociado a teratoma maduro de ovario.

show abstract

“…Estos tumores se suelen diagnosticar en niños y mujeres jóvenes que van de 10 a 30 años y tienen buen pronóstico. Edad, raza y etapa de la enfermedad son importantes predictores para la supervivencia (1,2) .…”

Section: Introductionunclassified

Immature ovarian teratoma. About a case

Sosa-Ramírez

Legal-Balmaceda

2019

Cir. parag

View full text Add to dashboard Cite

Los teratomas inmaduros de ovario (TIO) son tumores malignos formados por tejidos similares a los tejidos embrionarios o fetales. Presentamos el caso de una paciente de 16 años con una gran masa abdominal, que consulta debido a crecimiento abdominal de larga data. Una vez descartada la posibilidad de embarazo, se realizaron estudios complementarios (marcadores tumorales, TC) constatándose masa en anexo uterino derecho. Se decide ir a cirugía. Posteriormente la paciente realiza seguimiento Departamento de oncología pediátrica para tratamiento adyuvante.

show abstract

The influence of age and other prognostic factors associated with survival of ovarian immature teratoma — A study of 1307 patients

Cited by 18 publications

References 22 publications

Ovarian teratoma in children: a plea for collaborative clinical study

Ovarian teratoma in children: a plea for collaborative clinical study

Gliomatosis peritoneal asociada a teratoma maduro de ovario

Immature ovarian teratoma. About a case

Contact Info

Product

Resources

About