The influence of age, gender and ABO blood group on soluble endothelial cell markers and adhesion molecules

Blann, Andrew D.; Daly, Ray; Amiral, Jean

doi:10.1046/j.1365-2141.1996.d01-1486.x

Cited by 97 publications

(78 citation statements)

References 7 publications

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“…At healthy adulthood, the stability of sICAM-1 level across age is well known. 31,32,34,48 In our study, men had a slightly higher sICAM-1 level than women, probably due to the discrepancy in the older age group (48 -55 years). The variation of sICAM-1 level according to sex has not been established yet.…”

Section: Icam-1 Gene Polymorphismmentioning

confidence: 58%

Association between Gly241Arg ICAM-1 gene polymorphism and serum sICAM-1 concentration in the Stanislas cohort

et al. 2003

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Intracellular adhesion molecule-1 (ICAM-1), a cellular adhesion molecule that mediates the interaction of activated endothelial cells with leukocytes, is involved in various inflammatory and cardiovascular disorders. The relation between these markers and genetic polymorphism, however, remains to be elucidated. The aim of this study is to estimate the effect of a single-base polymorphism at codon 241 in exon 4 of ICAM-1 gene on serum sICAM-1 concentration in a healthy population, taking into account other biological determinants of sICAM-1 level. Serum sICAM-1 levels and the G/R241 polymorphism of the ICAM-1 gene were measured in a large healthy population consisting of 413 children aged 6-21 years and 363 adults aged 38-55 years extracted from the Stanislas cohort. The R241 allele was significantly associated with lower sICAM-1 levels and explained 3.4 and 1.9% of the sICAM-1 variability in children and adults, respectively. A codominant pattern contributed better to the model after adjustment for covariates as the RR homozygote effect was higher than that of the GR heterozygote. Moreover, significant independent associations were found between sICAM-1 and smoking, insulin resistance index (HOMA IR), interleukin-6 level, and alkaline phosphatase and aspartate aminotransferase activities. In conclusion, this study revealed a significant association between the G/R241 ICAM-1 polymorphism and serum sICAM-1 levels, probably due to the impairment in binding of ICAM-1 to leukocyte integrin Mac-1 protein.

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Section: Icam-1 Gene Polymorphismmentioning

confidence: 58%

Association between Gly241Arg ICAM-1 gene polymorphism and serum sICAM-1 concentration in the Stanislas cohort

et al. 2003

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“…This may account for the differing results between the two studies although we could not find any association between age and levels of circulating VCAM-1. Indeed, where age has been found to correlate with levels of soluble VCAM-1 the association has been positive [23,29]. The study reported by Steiner et al included smokers whereas we excluded smokers and this may point to some interaction between cigarette smoking and diabetes with regard to levels of VCAM-1.…”

Section: Discussionmentioning

confidence: 87%

Soluble vascular cell adhesion molecule-1 and E-selectin levels in relation to vascular risk factors and to E-selectin genotype in the first degree relatives of NIDDM patients and in NIDDM patients

1998

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The first degree relatives of non-insulin-dependent diabetes mellitus (NIDDM) patients are at increased risk of coronary artery disease and also have a lifetime risk of NIDDM of up to 40 % [1]. The development of these conditions appears to be predicted by the presence of features of insulin resistance and associated clustering of atherosclerotic risk in these subjects [2].Adhesion molecules are expressed on the cellular surface of endothelium in response to inflammatory stimuli [3] and can also be detected in soluble form in the circulation. The cellular adhesion molecules E-selectin and vascular cell adhesion molecule-1 (VCAM-1) are thought to play a role in the early stages of vascular disease by facilitating the attachment of leucocytes to, and the transmigration of leucocytes through, the endothelium [4]. It is possible that circulating forms of these adhesion molecules may also have functional importance [5]. The source Diabetologia (1998) Summary To investigate the metabolic and genetic associations of levels of soluble adhesion molecules, plasma levels of soluble E-selectin and vascular cell adhesion molecule-1 were measured in 60 non-insulin-dependent diabetes mellitus (NIDDM) patients, 60 first-degree relatives of NIDDM patients and 60 control subjects, none of whom displayed clinical features of vascular disease. In addition, E-selectin A561C genotype, coding for a serine to arginine change, was determined. E-selectin levels were elevated in the patient group; 57 [52±63] (mean [95 % confidence intervals]) ng/ml, compared with both relatives; 44 [39±50] ng/ml p = 0.001 and controls 39.5 [36±43] ng/ml p = 0.0001. E-selectin levels correlated with triglycerides, tissue-plasminogen activator and plasminogen activator inhibitor-1 activity in all groups. Levels of E-selectin were related to E-selectin genotype, being higher in subjects possessing the arginine allele (51.4 vs 44.5 ng/ml p < 0.05). E-selectin levels were higher in males than females in controls (

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“…In multivariable analyses, male sex remained a strong predictor of higher sCAMs. Blann et al 28 reported that levels of sE-selectin in normal subjects were significantly higher in males than in females, although they did not find any significant differences in levels of sICAM-1 or sVCAM-1. 17␤-Estradiol has been shown by two groups to reduce IL-1-induced expression of CAMs at the mRNA level by inhibiting transcription in vitro, 29,30 with conflicting results reported by a third group using different methods.…”

Section: Discussionmentioning

confidence: 98%

Soluble Cell Adhesion Molecules in Hypertriglyceridemia and Potential Significance on Monocyte Adhesion

Abe

El-Masri

Kimball

et al. 1998

ATVB

199

145

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Abstract-Hypertriglyceridemia may contribute to the development of atherosclerosis by increasing expression of cell adhesion molecules (CAMs). Although the cellular expression of CAMs is difficult to assess clinically, soluble forms of CAMs (sCAMs) are present in the circulation and may serve as markers for CAMs. In this study, we examined the association between sCAMs and other risk factors occurring with hypertriglyceridemia, the effect of triglyceride reduction on sCAM levels, and the role of soluble vascular cell adhesion molecule-1 (sVCAM-1) in monocyte adhesion in vitro. Compared with normal control subjects (nϭ20), patients with hypertriglyceridemia and low HDL (nϭ39) had significantly increased levels of soluble intercellular adhesion molecule-1 (sICAM-1) (316Ϯ28.8 versus 225Ϯ16.6 ng/mL), sVCAM-1 (743Ϯ52.2 versus 522Ϯ43.6 ng/mL), and soluble E-selectin (83Ϯ5.9 versus 49Ϯ3.6 ng/mL). ANCOVA showed that the higher sCAM levels in patients occurred independently of diabetes mellitus and other risk factors. In 27 patients who received purified n-3 fatty acid (Omacor) 4 g/d for Ն7 months, triglyceride level was reduced by 47Ϯ4.6%, sICAM-1 level was reduced by 9Ϯ3.4% (Pϭ.02), and soluble E-selectin level was reduced by 16Ϯ3.2% (PϽ.0001), with the greatest reduction in diabetic patients. These results support previous in vitro data showing that disorders in triglyceride and HDL metabolism influence CAM expression and treatment with fish oils may alter vascular cell activation. In a parallel-plate flow chamber, recombinant sVCAM-1 at the concentration seen in patients significantly inhibited adhesion of monocytes to interleukin-

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The influence of age, gender and ABO blood group on soluble endothelial cell markers and adhesion molecules

Cited by 97 publications

References 7 publications

Association between Gly241Arg ICAM-1 gene polymorphism and serum sICAM-1 concentration in the Stanislas cohort

Association between Gly241Arg ICAM-1 gene polymorphism and serum sICAM-1 concentration in the Stanislas cohort

Soluble vascular cell adhesion molecule-1 and E-selectin levels in relation to vascular risk factors and to E-selectin genotype in the first degree relatives of NIDDM patients and in NIDDM patients

Soluble Cell Adhesion Molecules in Hypertriglyceridemia and Potential Significance on Monocyte Adhesion

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