The influence of air-suspended particulate concentration on the incidence of suicide attempts and exacerbation of schizophrenia

Abstract

The main objective of this study was to evaluate the role of the concentration of solid air-suspended particles (SSP) in the incidence of mental disorders. The study is based on 1,871 cases, registered in the Beer-Sheva Mental Health Center (BS-MHC) at Ben-Gurion University (Israel) during a 16-month period from 2001 to 2002; 1,445 persons were hospitalized due to exacerbation of schizophrenia (ICD-10: F20-F29) and 426 after committing a suicide attempt using a variety of means as coded in the ICD-10 (ICD-10: X60-X84). Pearson and Spearman test correlations were used; the statistical significance was tested at p < 0.1. A significant correlation between variations of SSP number concentration (N C ) during eastern desert wind during early morning hours and number of suicide attempts, N SU , was found (ρ > 0.3, p < 0.05), whereas correlation between N C and N SU during western air streams (sea breeze) was not observed (p > 0.2). A trend towards positive correlation (ρ > 0.2, p < 0.1) between the N C and number of persons with exacerbation of schizophrenia as manifested in psychotic attack (N PS ) in periods with dominant eastern winds (4-9 am, local time) has been observed, while in the afternoon and evening hours (1-8 pm local time) with dominant western winds, N C and N PS are not correlated (p > 0.1). Obviously, concentration of SSP is not the one and only parameter of air pollution state determining meteorological-biological impact, involving incidence of mental disorders, although its role can scarcely be overstated. However, since it is one of the simplest measured parameters, it could be widely used and helpful in the daily struggle for human life comfort in semi-arid areas as well as urban and industrial surroundings, where air pollution reaches crucial values. This study may permit determination of the limits for different external factors, which do not overcome threshold values (without provoking avalanche situations), to single out the group of people at increased risk (with according degree of statistic probability), whose reactions to the weather violations can involve the outbreak of frustration points and prevent or alleviate detrimental mental effects.

Developmental exposures to ultrafine particle air pollution reduces early testosterone levels and adult male social novelty preference: Risk for children’s sex-biased neurobehavioral disorders

“…A compelling case for the involvement of early life air pollution (AP) exposures and ASD is suggested by a growing number of epidemiological studies (Volk et al, 2013, 2014, 2011; Becerra et al, 2013; Jung et al, 2013; Roberts et al, 2013a; Windham et al, 2006; Kalkbrenner et al, 2010). AP has also been linked to impaired cognitive abilities (Wang et al, 2009; van Kempen et al, 2012), and attention-related deficits (Siddique et al, 2011) as well as to schizophrenia (Duan et al, 2018; Eguchi et al, 2018; Yackerson et al, 2013; Pedersen et al, 2004), notably all neurobehavioral disorders with male-biased prevalence rates. These disorders also frequently include abberant social behaviors.…”

Association between air pollution and suicide: a time series analysis in four Colombian cities

“…According to the hypothesis of neuroinflammation, air contaminants could cause an increase in cytokines and reactive oxygen species, and consequently self-aggressive behavior [ 14 , 15 ]. The causal mechanisms between air pollution and suicide might not only involve this direct pathway via inflammation, but also the exacerbation of mental disorders that increase the risk of suicidal behavior [ 16 , 17 ]. Nonetheless, these pathways are not yet clearly established, and are far from being biologically proven.…”

Influence of exposure to coarse, fine and ultrafine urban particulate matter and their biological constituents on neural biomarkers in a randomized controlled crossover study

“…In recent years, epidemiological studies have reported associations between daily air pollution and hospital admissions or emergency room visits for Parkinson's disease (Zanobetti et al. 2014) and neuro-psychological responses such as depression and suicide attempt/mortality (Bakian et al 2015; Kim et al 2010; Szyszkowicz et al 2009; Szyszkowicz et al 2010; Yackerson et al. 2014).…”