The influence of alendronate on osseointegration of nanotreated dental implants in New Zealand rabbits

Abstract

The systemic administration of ALN was not found to affect histological osseointegration of implants in animals with a hormonal status resembling that of postmenopausal healthy women. Further research will be needed to investigate this approach.

Osseointegration of standard and mini dental implants: a histomorphometric comparison

“…Subsequently, the sections were stained with toluidine blue and basic fuchsin similar to other studies [21, 22, 50]. The specimen sections were evaluated at the most central saggital section of each implant under an optical microscope after staining.…”

Evaluating the osseointegration of nanostructured titanium implants in animal models: Current experimental methods and perspectives (Review)

“…However, this species shows the fewest similarities to human bone, and its small size, which also limits the quantity and size of inserted implants, is a significant disadvantage. [67][68][69][70][71][72] The most common bones for implantation are a miniature pig maxilla [63][64][65][66] and a rabbit femur. 67,69,70,72 The most frequently used experimental animals, their age/weight (according to the primary literature), the bones selected for implantation, and healing time are shown in Table I.…”

“…Tissue blocks 2-4 mm thick require approximately 12 h for penetration. 72,75 Slightly thicker samples require approximately 24 h, 71 but some researchers recommend up to 5 days for 16 mm thick samples. 63 An important factor affecting the fixation time is the ratio of spongy bone (with relatively easy fixation) to compact bone (which requires a longer fixation time).…”

“…68,71,72,75 The time required for dehydration and saturation by resin can be shortened using an automatic embedding device with an agitation and vacuum system. 75 The samples are put in methyl Fig.…”

Effects of alendronate on the peri‐implant bone in rats

“…In addition to these clinical reports, there have been a few animal studies dealing with the effect of oral bisphosphonates on implant osseointegration (Kurth et al , ; Chacon et al , ; Eberhardt et al , ; Viera‐Negron et al , ; Yildiz et al , ; Tsetsenekou et al , ). However, most of these animal studies used bisphosphonates other than alendronate or were performed on sites other than jaw bones.…”