The influence of amino acids on the formation of nanocrystalline hydroxyapatite

Rosseeva, Elena; Голованова, О. А.; Frank-Kamenetskaya, O. V.

doi:10.1134/s1087659607030170

Cited by 24 publications

(20 citation statements)

References 4 publications

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“…150 Â 3.5 nm, were prepared with aspartic acid. The above work inspired further investigations into the nature and stability of the interaction of a series of amino acids with HA [19][20][21][22].…”

Section: Introductionmentioning

confidence: 93%

Amino acid synergetic effect on structure, morphology and surface properties of biomimetic apatite nanocrystals

et al. 2009

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Section: Introductionmentioning

confidence: 93%

Amino acid synergetic effect on structure, morphology and surface properties of biomimetic apatite nanocrystals

et al. 2009

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“…Consequently, it has been evidenced that methods for preparation and any changes in stoichiometry (Ca/P ratio) significantly affect IEP of HAP. 147 Pure HAP powders precipitated in acidic conditions were, for example, shown to possess 1-3 pH units lower IEPs compared with those precipitated from alkaline solutions. 148 HAP particles in sols are also excessively prone to selective leaching of ions, which leaves different f-potential versus pH curves of the same powder in different solvent media as a consequence.…”

Section: Mechanism Of Formation Of Hap By Precipitationmentioning

confidence: 99%

Nanosized hydroxyapatite and other calcium phosphates: Chemistry of formation and application as drug and gene delivery agents

2010

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The first part of this review looks at the fundamental properties of hydroxyapatite (HAP), the basic mineral constituent of mammalian hard tissues, including the physicochemical features that govern its formation by precipitation. A special emphasis is placed on the analysis of qualities of different methods of synthesis and of the phase transformations intrinsic to the formation of HAP following precipitation from aqueous solutions. This serves as an introduction to the second part and the main subject of this review, which relates to the discourse regarding the prospects of fabrication of ultrafine, nanosized particles based on calcium phosphate carriers with various therapeutic and/or diagnostic agents coated on and/or encapsulated within the particles. It is said that the particles could be either surface-functionalized with amphiphiles, peptides, proteins, or nucleic acids or injected with therapeutic agents, magnetic ions, or fluorescent molecules. Depending on the additive, they could be subsequently used for a variety of applications, including the controlled delivery and release of therapeutic agents (extracellularly or intracellularly), magnetic resonance imaging and hyperthermia therapy, cell separation, blood detoxification, peptide or oligonucleotide chromatography and ultrasensitive detection of biomolecules, and in vivo and in vitro gene transfection. Calcium phosphate nanoparticles as carriers of therapeutic agents that would enable a controlled drug release to treat a given bone infection and at the same be resorbed in the body so as to regenerate hard tissue lost to disease are emphasized hereby as one of the potentially attractive smart materials for the modern medicine.

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“…The morphology of HAp nanoparticles also depends on additives, such as surfactant molecules [104,105] (cf micelle-templated method described in the next paragraph, and emulsion methods described in section 2.2.5), alcohol [106], amino acids [107][108][109], citrates [110,111], poly(acrylic acid) [112,113], poly(ethylene imine) [114,115], poly(ethylene oxide) (poly(ethylene glycol)) [116,117], poly(vinyl alcohol) [118,119] and biopolymers [119], mainly due to the inhibition of crystal growth by preferentially adsorbing the additives onto a HAp surface (a or c plane).…”

Section: Wet Chemical Precipitationmentioning

confidence: 99%

Hydroxylapatite nanoparticles: fabrication methods and medical applications

Okada

Furuzono

2012

Science and Technology of Advanced Materials

126

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Hydroxylapatite (or hydroxyapatite, HAp) exhibits excellent biocompatibility with various kinds of cells and tissues, making it an ideal candidate for tissue engineering, orthopedic and dental applications. Nanosized materials offer improved performances compared with conventional materials due to their large surface-to-volume ratios. This review summarizes existing knowledge and recent progress in fabrication methods of nanosized (or nanostructured) HAp particles, as well as their recent applications in medical and dental fields. In section 1, we provide a brief overview of HAp and nanoparticles. In section 2, fabrication methods of HAp nanoparticles are described based on the particle formation mechanisms. Recent applications of HAp nanoparticles are summarized in section 3. The future perspectives in this active research area are given in section 4.

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The influence of amino acids on the formation of nanocrystalline hydroxyapatite

Cited by 24 publications

References 4 publications

Amino acid synergetic effect on structure, morphology and surface properties of biomimetic apatite nanocrystals

Amino acid synergetic effect on structure, morphology and surface properties of biomimetic apatite nanocrystals

Nanosized hydroxyapatite and other calcium phosphates: Chemistry of formation and application as drug and gene delivery agents

Hydroxylapatite nanoparticles: fabrication methods and medical applications

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